Prevalence of liver cell dysplasia and association with HCC in a series of 100 cirrhotic liver explants

Journal of Hepatology

Volumn 27, Issue 5, 1997, Pages 835-842

  Le Bail, Brigitte ^a,b   Bernard, Pierre Henri ^b   Carles, Jacques ^b   Balabaud, Charles ^a,b   Bioulac Sage, Paulette ^a,b  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b HÔPITAL PELLEGRIN   (France)

Author keywords

Dysplasia; Hepatocellular carcinoma; Liver cell dysplasia; Liver cirrhosis; Premalignant conditions

Indexed keywords

ARTICLE; BILIARY TRACT DISEASE; DISEASE ASSOCIATION; DISEASE SEVERITY; DYSPLASIA; HEPATITIS B VIRUS; HIGH RISK POPULATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MORPHOMETRICS; PREVALENCE; PRIORITY JOURNAL;

EID: 0343145738     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(97)80321-2     Document Type: Article

References (40)

1. Okuda K. Hepatocellular carcinoma: recent progress. Hepatology. 15:1992;948-963.
2. Moradpour D, Wands JR. The molecular mechanisms of hepatocellular carcinoma. J Viral Hepatitis. 1:1994;265-278.
3. Okuda K. What is the precancerous lesion for hepatocellular carcinoma in man? J Gastroenterol Hepatol. 1:1986;79-85.
4. Nakanuma Y, Terada T, Ueda K, Terasaki S, Nonomura A, Matsui O. Adenomatous hyperplasia of the liver as a precancerous lesion. Liver. 13:1993;1-9.
5. Theise ND. Macroregenerative (dysplastic) nodules and hepato-carcinogenesis. Semin Liver Dis. 15:1995;360-371.
6. Le Bail B, Belleannée G, Bernard P-H, Saric J, Balabaud C, Bioulac-Sage P. Adenomatous hyperplasia in cirrhotic livers: histological evaluation, cellular density and proliferative activity of 35 macronodular lesions in the cirrhotic explants of 10 adult French patients. Hum Pathol. 26:1995;897-906.
7. Anthony PP, Vogel CL, Barker LF. Liver cell dysplasia: a premalignant condition. J Clin Pathol. 26:1973;217-223.
8. Ishak KG, Anthony PP, Sobin LH. Histological Typing of Tumours of the Liver. 2nd ed. World Health Organization, International Histological Classification of Tumours. 1994;Springer-Verlag, Berlin.
9. Watanabe S, Okita K, Harada T, Kodama T, Numa Y, Takemoto T, et al. Morphologic studies of the liver cell dysplasia. Cancer. 51:1983;2197-2205.
10. Bartok l, Remenar E, Toth J, Duschanek P, Kanyar B. Clinicopathological studies of liver cirrhosis and hepatocellular carcinoma in a general hospital. Hum Pathol. 12:1981;794-803.
11. Akagi G, Furuya K, Kanamura A, Chihara T, Otsuka H. Liver cell dysplasia and hepatitis B surface antigen in liver cirrhosis and hepatocellular carcinoma. Cancer. 54:1984;315-318.
12. Roncalli M, Borzio M, De Biagi G, Servida E, Cantaboni A, Sironi M, et al. Liver cell dysplasia and hepatocellular carcinoma: a histological and immunohistochemical study. Histopathology. 9:1985;209-221.
13. Roncalli M, Borzio M, De Biagi G, Ferrari AR, Macchi R, Tombesi VM, et al. Liver cell dysplasia in cirrhosis: a serologic and immunohistochemical study. Cancer. 57:1986;1515-1521.
14. Roncalli M, Borzio M, Tombesi MV, Ferrari A, Servida E. A morphometric study of liver cell dysplasia. Hum Pathol. 19:1988;471-474.
15. Cohen C, Berson SD. Liver cell dysplasia in normal, cirrhotic, and hepatocellular carcinoma patients. Cancer. 57:1956;1535-1538.
16. Matturi L, Bauer D. Morphometric characteristics of hepatocellular dysplasia. Anal Quant Cytol Histol. 10:1988;339-342.
17. Giannini A, Zampi G, Bartoloni F, Omer S. Morphological precursors of hepatocellular carcinoma: a morphometric analysis. Hepatogastroenterology. 34:1987;95-97.
18. Roncalli M, Borzio M, Brando B, Colloredo G, Servida E. Abnormal DNA content in liver-cell dysplasia: a flow cytometric study. Int J Cancer. 44:1989;204-207.
19. Rubin MR, Derose PB, Cohen C. Comparative image cytometric DNA ploidy of liver cell dysplasia and hepatocellular carcinoma. Mod Pathol. 7:1994;677-680.
20. Thomas RM, Berman JJ, Yetter RA, Moore GW, Hutchins GM. Liver cell dysplasia: a DNA aneuploid lesion with distinct morphological features. Hum Pathol. 23:1992;496-503.
21. Zhao M, Zhang NX, Du ZY, Laissue JA, Zimmermann A. Three types of liver cell dysplasia (LCD) in small cirrhotic nodules are distinguishable by karyometry and PCNA labelling, and their features resemble distinct grades of hepatocellular carcinoma. Histol Histopathol. 9:1994;73-83.
22. Police L, Ricco R, Russo S, Maiorano E, Pagniello G, Delfino-Pesce V. Hepatocellular dysplasia: immunohistochemical and morphometrical evaluation. Appl Pathol. 6:1988;73-81.
23. Zhao M, Zhang NX, Laissue JA, Zimmerman A. Immunohistochemical analysis of p53 protein overexpression in liver cell dysplasia and in hepatocellular carcinoma. Virchows Arch. 424:1994;613-621.
24. Zhao M, Zhang NX, Economou M, Blaha L, Laissue JA, Zimmerman A. Immunohistochemical detection of bcl2 protein in liver lesions: bcl2 protein is expressed in hepatocellular carcinoma but not in liver cell dysplasia. Histopathology. 25:1994;237-245.
25. Henmi A, Uchida A, Shikata T. Karyometric analysis of liver cell dysplasia and hepatocellular carcinoma: evidence against precancerous nature of liver cell dysplasia. Cancer. 55:1995;2594-2599.
26. Crawford JM. Pathologic assessment of liver cell dysplasia and benign liver tumors: differentiation from malignant tumors. Semin Diag Pathol. 7:1990;115-128.
27. Podda M, Roncalli M, Battezzati PM, Borzio M, Bruno S, Servida E, et al. Liver-cell dysplasia and hepatocellular carcinoma. Ital J Gastroenterol. 24:1992;39-42.
28. Le Bail B, Bioulac-Sage P, Tran Van Nhieu J, Zafrani ES. Approche actuelle de la carcinogenèse hépatique. De la cirrhose au carcinome hépatocellulaire. Ann Pathol. 15:1995;332-347.
29. Adachi Ea, Hashimoto H, Tsuneyoshi M. Proliferating cell nuclear antigen in hepatocellular carcinoma and small liver cell dysplasia. Cancer. 72:1993;2902-2909.
30. Ferrell L, Crawford JM, Dhillon AP, Scheuer PJ, Nakanuma Y. Proposal for standardized criteria for the diagnosis of benign, borderline and malignant lesions arising in cirrhotic advanced liver disease. Am J Surg Pathol. 17:1993;1113-1123.
31. International Working Party. Terminology of nodular hepatocellular lesions Hepatology. 22:1995;983-93.
32. Lefkowitch JH, Apfelbaum TF. Liver cell dysplasia and hepatocellular carcinoma in non-A, non-B hepatitis. Arch Pathol Lab Med. 111:1987;170-173.
33. Sakurai M. Liver cell dysplasia and hepatitis B surface and core antigens in cirrhosis and hepatocellular carcinoma of autopsy cases. Acta Path Jap. 28:1978;705-719.
34. Ho JC, Wu PC, Mak TK. Liver cell dysplasia in association with hepatocellular carcinoma, cirrhosis and hepatitis B surface antigen in Hong Kong. Int J Cancer. 28:1981;571-574.
35. Hytiroglou P, Theise ND, Schwartz M, Mor E, Miller C, Thung SN. Macroregenerative nodules in a series of adult cirrhotic liver explants: issues of classification and nomenclature. Hepatology. 21:1995;703-708.
36. Ganne-Carrié N, Chastang C, Chapel F, Munz C, Pateron D, Sibony M, et al. Predictive score for the development of hepatocellular carcinoma and additional value of liver large cell dysplasia in western patients with cirrhosis. Hepatology. 23:1996;1112-1118.
37. Borzio M, Bruno S, Roncalli M, Mels GC, Ramella G, Borzio E. Liver cell dysplasia is a major risk factor for hepatocellular carcinoma in cirrhosis: a prospective study. Gastroenterology. 108:1995;812-817.
38. Ferrell L, Wright T, Lake J, Roberts J, Ascher N. Incidence and diagnostic features of macroregenerative nodules vs small hepatocellular carcinoma in cirrhotic livers. Hepatology. 16:1992;1372-1381.
39. Nakanuma Y, Hirata K. Unusual hepatocellular lesions in primary biliary cirrhosis resembling but unrelated to hepatocellular neoplasms. Virchows Arch A Pathol Anat. 422:1993;17-23.
40. Le Bail B, Faouzi S, Boussarie L, Balabaud C, Bioulac-Sage P, Rosenbaum J. Extracellular matrix and integrin expression in early hepatocarcinogenesis in human cirrhotic livers. J Pathol. 181:1997;330-337.