Enantioselective synthesis of both enantiomers of 2-amino-6-phosphonohexanoic acid [(R)- and (S)-AP6], a potent and specific agonist of AMPA receptor subtype

Tetrahedron Asymmetry

Volumn 8, Issue 9, 1997, Pages 1511-1514

  García Barradas, Oscar ^a   Juaristi, Eusebio ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 6 PHOSPHONOHEXANOIC ACID; AMPA RECEPTOR; PHOSPHORAMIDIC ACID;

ARTICLE; DRUG SYNTHESIS; ENANTIOMER; IN VITRO STUDY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; REACTION ANALYSIS;

EID: 0343144850     PISSN: 09574166     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0957-4166(97)00162-6     Document Type: Article

References (11)

1. Ferkany, J. W.; Willets, J.; Borosky, S. A.; Clissold, D. B.; Karbon, E. W.; Hamilton, G. S. Bioor. and Med. Chem. Lett., 1993, 3, 33.
2. a) Collingridge, G. L.; Sawyer, W. TIPS, 1990, 11, 290.
3. b) Klockgether, T.; Turski, L. Ann. Neurology, 1990, 28, 529.
4. c) Young, H. B.; Greenamyre, J. T.; Hollingsworth, Z.; Albin, R. I.; D'Amato, C.; Shoulson, I.; Penny, J. B. Science, 1988, 241, 981.
5. d) Zivin, J. A.; Choi, D. W. Sci. Amer., 1991, 265, 36.
6. e) Dingledine, R.; McBain, C. J.; McNamara, J. O. TIPS, 1990, 11, 334.
7. Harris, E. W.; Cotman, C. W. Exp. Brain Res., 1983, 52, 455.
8. García-Barradas, O.; Juaristi, E. Tetrahedron, 1995, 51, 3423.
9. Juaristi, E.; Anzorena, J. L.; Boog, A.; Madrigal, D.; Seebach, D.; García-Baez, E. V.; García-Barradas, O.; Gordillo, B.; Kramer, A.; Steiner, I.; Zurcher, S. J. Org. Chem., 1995, 60, 6408.
10. 4
11. For a description of general experimental data, see ref. 4.