Screening for novel drug effects with a microphysiometer: A potent effect of clofilium unrelated to potassium channel blockade

Life Sciences

Volumn 61, Issue 7, 1997, Pages

  Rabinowitz, Joshua D ^b   Rigler, Per ^b   Carswell Crumpton, Cathy ^b   Beeson, Craig ^a,b   McConnell, Harden M ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

Antiarrhythmic agent; Cation channel blocker; Cellular metabolism; Clofilium; Cytosensor; Drug screen; Microphysiometer; Potassium channel blocker

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BRETYLIUM TOSYLATE; CARBAMAZEPINE; CLOFILIUM; ION CHANNEL; LIDOCAINE; NIFEDIPINE; PHENYTOIN; POTASSIUM; POTASSIUM CHANNEL BLOCKING AGENT; PROPRANOLOL; TETRYLAMMONIUM; VERAPAMIL;

ANIMAL CELL; ARTICLE; BIOSENSOR; CELL LINE; CELL METABOLISM; CELL PROLIFERATION; CONTROLLED STUDY; CULTURE MEDIUM; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; INSTRUMENT; MICROSCOPY; NONHUMAN; POTASSIUM CONDUCTANCE; SCREENING; TECHNIQUE;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; APOPTOSIS; BIOSENSING TECHNIQUES; CALCIUM CHANNEL BLOCKERS; CELL LINE; CHO CELLS; CRICETINAE; HUMANS; MICE; POTASSIUM CHANNEL BLOCKERS; QUATERNARY AMMONIUM COMPOUNDS; TUMOR CELLS, CULTURED;

ANIMALIA; MURINAE;

EID: 0343118753     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(97)00543-2     Document Type: Article

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