Polymer-supported synthesis of diverse perhydro-1,4-diazepine-2,5-diones

Tetrahedron Letters

Volumn 38, Issue 42, 1997, Pages 7299-7302

  Krchňák, Viktor ^a,b   Weichsel, Aleksandra S ^a  

^a Selectide Corporation   (United States)

^b Trega Biosciences Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIAZEPINE DERIVATIVE;

ARTICLE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REACTION ANALYSIS; TECHNIQUE; ULTRAVIOLET SPECTROPHOTOMETRY;

EID: 0343118176     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)01772-3     Document Type: Article

References (11)

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2. Thompson, L. A.; Ellman, J. A. Chem. Rev. 1996, 96, 555-600.
3. Barlos, K.; Chatzi, O.; Gatos, D.; Stavropoulos, G. Int. J. Pept. Protein Res. 1991, 37, 513-520.
4. Offer, J.; Quibell, M.; Johnson, T. J. Chem. Soc., Perkin Trans. I. 1996, 175-182, and references cited therein.
5. Look, G. C; Murphy, M. M.; Campbell, D. A.; Gallop, M. A. Tetrahedron Lett. 1995, 36, 2937-2940.
6. Gordon, D. W.; Steele, J. Bioorg. Med. Chem. 1995, 5, 47-50.
7. Carpino, L. A.; Elfaham, A. J. Am. Chem. Soc. 1995, 117, 5401-5402.
8. Krchnak, V.; Weichsel, A.S.; Cabel, D.; Lebl, M. Molecular Diversity and Combinatorial Chemistry for Drug Discovery; Chaiken, I.; Janda, K. Eds.; ACS Books: Washington, 1996; pp. 99-117.
9. Simon, R. J.; Kaina, R. S.; Zuckermann, R. N.; Huebner, V. D.; Jewell, D. A.; Banville, S.; Simon, N. G.; Wang, L.; Rosenberg, S.; Marlowe, C. K.; Spellmeyer, D. C.; Tan, R.; Frankel, A. D.; Santi, D. V.; Cohen, F. E.; Bartlett, P. A. Proc. Natl. Acad. Sci. USA 1992, 89, 9367-9371.
10. 6) δ = 4.52-4.61 (m, 1 H), δ = 4.52-4.61 (m, 1 H), δ = 2.98-3.12 (m, 2 H), δ = 3.65 (d, J = 7 Hz, 1 H), δ = 5.07 (d, J = 7 Hz, 1 H), δ = 2.89 (s, 3 H), δ = 3.90-3.92 (m, 2 H), δ = 1.03-1.11 (m, 6 H).
11. Analytical gradient HPLC profile was run on a Protein & Peptide C18 4×250 mm analytical column (Vydac), gradient 0 - 60 % of ACN in 30 min. The purity was estimated based on analytical traces at 215 nm.