Comparative analysis of plasma 17-hydroxyprogesterone and cortisol responses to ACTH in patients with various adrenal tumors before and after unilateral adrenalectomy

Journal of Endocrinological Investigation

Volumn 23, Issue 5, 2000, Pages 287-294

  Tóth, Miklós ^a,b   Racz K ^a   Adleff, V ^a   Varga, I ^a   Futo L ^a   Jakab, C ^a   Karlinger, K ^b   Kiss, R ^a   Glaz E ^a  

^a 2nd Department of Medicine   (Hungary)

^b SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

Author keywords

17 Hydroxyprogesterone; 21 Hydroxylase; Adrenal; Adrenal tumors; Conn's syndrome; Cushing's syndrome; Pheochromocytoma; Response to ACTH

Indexed keywords

CORTICOTROPIN; HYDROCORTISONE; HYDROXYPROGESTERONE; TETRACOSACTIDE ZINC PHOSPHATE; VANILMANDELIC ACID;

ADRENAL CORTEX ADENOMA; ADRENAL TUMOR; ADRENALECTOMY; ADULT; ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION FUNCTION; CORTICOTROPIN TEST; DRUG MECHANISM; DRUG POTENTIATION; DRUG RESPONSE; FEMALE; HORMONE RESPONSE; HUMAN; MAJOR CLINICAL STUDY; MALE;

EID: 0343090391     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03343725     Document Type: Article

References (36)

1. Jockenhövel F., Kuck W., Hauffa B., Reinhardt W., Benker G., Lederbogen S., Olbricht T., Reinwein D. Conservative and surgical management of incidentally discovered adrenal tumors (incidentalomas). Endocrinol. Invest. 1992, 15: 331-337.
2. Turton D.B., O'Brian J.T., Shakir K.M.M. Incidental adrenal nodules: Association with exaggerated 17-hydroxyprogesterone response to adrenocorticotropic hormone. Endocrinol. Invest. 1992, 15: 789-796.
3. Seppel T., Schlaghecke R. Augmented 17α-hydroxyprogesterone response to ACTH stimulation as evidence of decreased 21-hydroxylase activity in patients with incidentally discovered adrenal tumours ("incidentalomas"). Clin. Endocrinol. (Oxf.) 1994, 41: 445-451.
4. Ambrosi B., Peverelli S., Passini E., Re T., Ferrario R., Colombo P., Sartorio A., Faglia G. Abnormalities of endocrine function in patients with clinically "silent" adrenal masses. Eur. J. Endocrinol. 1995, 132: 422-428.
5. Del Monte P., Bernasconi D., Bertolazzi L., Meozzi M., Badaracco B., Torre R., Marugo M. Increased 17α-hydroxyprogesterone response to ACTH in silent adrenal adenoma: cause or effect? Clin. Endocrinol. 1995, 42: 273-277.
6. Terzolo M., Osella G., Ali A., Borretta G., Magro G-P., Termine A., Paccotti P., Angeli A. Different patterns of steroid secretion in patients with adrenal incidentaloma. J. Clin. Endocrinol. Metab. 1996, 81: 740-744.
7. Bernini G.P., Brogi G., Vivaldi M.S., Argenio G.F., Sgro M., Moretti A., Salvetti A. 17-hydroxyprogesterone response to ACTH in bilat-eral and monolateral adrenal incidentalomas. J. Endocrinol. Invest. 1996, 19: 745-752.
8. Reincke M., Peter M., Sippell W.G., Allolio B. Impairment of 11α-hydroxylase but not 21-hydroxylase in adrenal "incidentalomas". Eur. J. Endocrinol. 1997, 136: 196-200.
9. Bondanelli M., Campo M., Trasforini G., Ambrosio M.R., Zatelli M.C., Franceschetti P., Valentini A., Pansini R., degli Uberti E.C. Evaluation of hormonal function in a series of incidentally discovered adrenal masses. Metabolism 1997, 46: 107-113.
10. Mantero F., Masini A.M., Opocher G., Giovagnetti M., Arnaldi G. Adrenal incidentaloma: an overview of hormonal data from the National Italian Study Group. Horm. Res. 1997, 47: 284-289.
11. Sartorio A., Conti A., Ferrero S., Giambona S., Re T., Passini E., Ambrosi B. Evaluation of markers of bone and collagen turnover in patients with active and preclinical Cushing's syndrome and in patients with adrenal incidentaloma. Eur. J. Endocrinol. 1998, 138: 146-152.
12. Tóth M., Rácz K., Gláz E. Increased plasma 17-hydroxy-progesterone response to ACTH in patients with non-hyperfunctioning adrenal adenomas is not due to a deficiency in 21-hydroxylase activity (Letter). J. Clin. Endocrinol. Metab. 1998, 83: 3756-3757.
13. Hensen J., Buhl M., Bähr V., Oelkers W. Endocrine activity of the "silent" adrenocortical adenoma is uncovered by response to corticotropin-releasing hormone. Klin. Wochenschr. 1990, 68: 608-614.
14. Tóth M., Rácz K., Varga I., Adleff V., Jakab Cs., Fütö L., Kiss R., Gláz E. Plasma dehydroepiandrosterone sulfate levels in patients with hyperfunctioning and non-hyperfunctioning adrenal tumors before and after adrenal surgery. Eur. J. Endocrinol. 1997, 136: 290-295.
15. Vecsei P., Onyechi J., Hornung J., Dietz R., Mast G., Hobler H. Use of corticosteroid antibodies for the study of corticosteroid biosynthesis in vitro. J. Steroid Biochem. 1975, 6: 383-387.
16. Varga I., Rácz K., Kiss R., Fütö L., Tóth M., Sergev O., Gláz E. Direct inhibitory effect of etomidate on corticosteroid secretion in human pathological adrenocortical cells. Steroids 1993, 58: 64-68.
17. Shimshi M., Ross F., Goodman A., Gabrilove J.L. Virilizing adrenocortical tumor superimposed on congenital adrenal hyperplasia. Am. J. Med. 1992, 93: 338-342.
18. Bevan J.S., Rees A. Dexamethasone-suppressible adrenal tumour in untreated 21-hydroxylase deficiency. Clin. Endocrinol. (Oxf.) 1996, 44: 733-737.
19. Nagasaka S., Kubota K., Motegi T., Hayashi E., Ohta M., Takahashi T., Iwasaki Y., Koike M., Nishikawa T., Sasano H., Murakami T. A case of silent 21-hydroxylase deficiency with persistent adrenal insufficiency after removal of an adrenal incidentaloma. Clin. Endocrinol. 1996, 44: 111-116.
20. Ravichandran R., Lafferty F., McGinnis M.J., Taylor H.C. Congenital adrenal hyperplasia presenting as massive adrenal incidentalomas in the sixth decade of life: report of two patients with 21-hydroxylase deficiency. J. Clin. Endocrinol. Metab. 1996, 81: 1776-1779.
21. Tóth M., Rácz K., Halász Z., Gláz E. Adrenal tumor associated with silent 21-hydroxylase deficiency in a male or with a classical form of 21-hydroxylase defect in a female? Clin. Endocrinol. (Oxf.) 1996, 45: 369-370.
22. Jaresch S., Kornely E., Kley H-K., Schlaghecke R. Adrenal incidentaloma and patients with homozygous or heterozygous congenital adrenal hyperplasia. J. Clin. Endocrinol. Metab. 1992, 74: 685-689.
23. Rácz K., Pinet F., Marton T., Szende B., Gláz E., Corvol P. Expression of steroidogenic enzyme messenger ribonucleic acids and corticosteroid production in aldosterone-producing and "nonfunctioning" adrenal adenomas. J. Clin. Endocrinol. Metab. 1993, 77: 677-682.
24. Beuschlein F., Schulze E., Mora P., Gensheimer H-P., Maser-Gluth C., Allolio B., Reincke M. Steroid 21-hydroxylase mutations and 21-hydroxylase messenger ribonucleic acid expression in human adrenocortical tumors. J. Clin. Endocrinol. Metab. 1998, 83: 2585-2588.
25. Gláz E., Rácz K., Varga I., Kiss R., Tóth M., Fütö L. Mineralocorticoid production of adrenal cortical adenomas. J. Steroid Biochem. 1993, 45: 57-64.
26. Morioka M., Tanaka H., Ohashi Y., Jin T-X., Komatsu F., Watanabe H. The analysis of steroidogenic activity in non-hyperfunctioning adrenocortical adenoma. Endocr. Jpn. 1997, 44: 647-653.
27. Suzuki H., Shibata H., Maruyama T., Ishimura Y., Saruta T. Significance of steroidogenic enzymes in the pathogenesis of hyperfunctioning and non-hyperfunctioning adrenal tumor. Steroids 1995, 60: 42-47.
28. Griffing G.T., Chobainian A.V., Egdahl R., Ehlers M.E., Melby J.C. An adrenal cyst associated with 19-nor-deoxycorticosterone excess and low renin hypertension. Clin. Exp. Hypertens. (A) 1989, 11: 317-321.
29. Kearney G.P., Mahoney E.M., Maher E., Harrison J.H. Functioning and nonfunctioning cysts of the adrenal cortex and medulla. Am. J. Surg. 1977, 134: 363-368.
30. Bruhn T.O., Engeland W.C., Anthony E.L.P., Gann D.S., Jackson I.M.D. Corticotropin-releasing factor in the adrenal medulla. Ann. N. Y. Acad. Sci. 1987, 512: 115-128.
31. Amico J.A., Clarke M.R., Watson C.G., Kim N.B., Bononi P.L., Crowley R.S., Horwitz M.J. Endothelin-1 gene expression in human pheochromocytoma. J. Lab. Clin. Med. 1993, 122: 667-672.
32. Bornstein S.R., Ehrhart-Bornstein M., Scherbaum W.A. Morphological and functional studies of the paracrine interaction between cortex and medulla in the adrenal gland. Microsc. Res. Tech. 1997, 36: 520-533.
33. Ehrhart-Bornstein M., Bornstein S.R., Scherbaum W.A. Sympathoadrenal system and immune system in the regulation of adrenocortical function. Eur. J. Endocrinol. 1996, 135: 19-26.
34. Nussdorfer G.G. Paracrine control of adrenal cortical function by medullary chromaffin cells. Pharmacol. Rev. 1996, 48: 495-530.
35. Inoue J., Oishi S., Naomi S., Umeda T., Sato T. Pheochromocytoma associated with adrenocortical adenoma: Case report and literature review. Endoc. Jpn. 1986, 33: 67-74.
36. Chen H., Doppman J.L., Chrousos G.P., Norton J.A., Nieman L.K., Udelsman R. Adrenocorticotropic hormone-secreting pheochromocytomas: The exception to the rule. Surgery 1995, 118: 988-995.