The computational challenge of linkage analysis: What causes diseases?

Computing in Science and Engineering

Volumn 1, Issue 3, 1999, Pages 18-25

  Daly, Mark J ^a  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0343057998     PISSN: 15219615     EISSN: None     Source Type: Journal    
DOI: 10.1109/5992.764212     Document Type: Article

References (18)

1. R.A. Fisher, "The Systematic Location of Genes by Means of Crossover Observations," American Naturalist, Vol. 56, 1922, pp. 406-411.
2. R.A. Fisher, "The Detection of Linkage with 'Dominant' Abnormalities," Annals of Eugenics, Vol. 6, 1935, pp. 187-201.
3. J.B.S. Haldane and C.A.B. Smith, "A New Estimate of the Linkage between the Genes for Colour-Blindness and Haemophilia in Man," Annals of Eugenics, Vol. 14, 1947, pp. 10-31.
4. N. Morton, "Sequential Tests for the Detection of Linkage," American J. Human Genetics, Vol. 7, 1955, pp. 277-318.
5. R.C. Elston and J. Stewart, "A General Model for the Analysis of Pedigree Data," Human Heredity, Vol. 21, 1971, pp. 523-542.
6. J. Ott, "Estimation of the Recombination Fraction in Human Pedigree - Efficient Computation of the Likelihood for Human Linkage," American J. Human Genetics, Vol. 26, 1974, pp. 597-599.
7. G.M. Lathrop et al., "Strategies for Multilocus Linkage in Humans," Proc. Nat'l Academy of Science, Vol. 81, June 1984, pp. 3443-3446.
8. R.W. Cottingham, R.M. Idury, and A.A. Schaffer, "Fast Sequential Genetic Linkage Computations," American J. Human Genetics, Vol. 53, July 1993, pp. 252-263.
9. J.R. O'Connell and D.E. Weeks, "The VITESSE Algorithm for Rapid Exact Multilocus Linkage Analysis via Genotype Set-Recording and Fuzzy Inheritance," Nature Genetics, Vol. 11, Dec. 1995, pp. 402-408.
10. C. Dib et al., "A Comprehensive Genetic Map of the Human Genome Based on 5,264 Microsatellites," Nature, Vol. 380, 14 Mar. 1996, pp. 152-154.
11. D. Wang et al., "Large-Scale Identification, Mapping, and Genotyping of Single-Nucleotide Polymorphisms in the Human Genome," Science, Vol. 280, 15 May 1998, pp. 1077-1082.
12. E.S. Lander and P. Green, "Construction of Multilocus Genetic Linkage Maps in Humans," Proc. Nat'l Academy of Sciences, Vol. 84, Apr. 1987, pp. 2363-2367.
13. L. Kruglyak, M.J. Daly, and E.S. Lander, "Rapid Multipoint Linkage Analysis of Recessive Traits in Nuclear Families, Including Homozygosity Mapping," American J. Human Genetics, Vol. 56, Feb. 1995, pp. 519-527.
14. L. Kruglyak et al., "Parametric and Non-Parametric Linkage Analysis: A Unified Multipoint Approach," American J. Human Genetics, Vol. 58, No. 6, 1996, pp. 1347-1363.
15. R.M. Idury and R.C. Elston, "A Faster and More General Hidden Markov Model Algorithm for Multipoint Likelihood Calculations," Human Heredity, Vol. 47, No. 4, 1997, pp. 197-202.
16. L. Kruglyak and E.S. Lander, "Faster Multipoint Linkage Analysis using Fourier Transforms," J. Computational Biology, Vol. 5, No. 1, 1997, pp. 1-7.
17. E. Sobel and K. Lange, "Descent Graphs in Pedigree Analysis: Applications to Haplotyping, Location Scores, and Marker Sharing Analysis," American J. Human Genetics, Vol. 58, June 1996, pp. 1323-1337.
18. J. Ott, "How Do You Compute a LOD Score?" Nature Genetics, Vol. 11, Dec. 1995, pp. 354-355.