Evaluation of pentoxifylline in experimental spinal cord ischemia

European Journal of Cardio-thoracic Surgery

Volumn 12, Issue 4, 1997, Pages 648-653

  Türköz, Ayda ^a   Türköz, Rýza ^b,c   Yörükoǧlu, Kutsal ^a   Onat, Ümit ^a   Saǧýroǧlu, Emel ^a   Şaǧban, Mansur ^b  

^a DOKUZ EYLUL UNIVERSITY   (Turkey)

^b Izmir State Hospital   (Turkey)

^c NONE   (Turkey)

Author keywords

Delayed paraplegia; Leukocyte; Neutrophil; Spinal cord injury; Spinal cord ischemia

Indexed keywords

PENTOXIFYLLINE;

ABDOMINAL AORTA; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA OCCLUSION; AORTA SURGERY; ARTICLE; DRUG EFFECT; DRUG SCREENING; INFLAMMATORY INFILTRATE; INTRAVENOUS DRUG ADMINISTRATION; MACROPHAGE; NEUROPROTECTION; NEUTROPHIL; NONHUMAN; PARAPLEGIA; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; RABBIT; SPINAL CORD FUNCTION; SPINAL CORD ISCHEMIA; THORACIC AORTA;

ANIMALS; NEUTROPHIL ACTIVATION; PARAPLEGIA; PENTOXIFYLLINE; RABBITS; REPERFUSION INJURY; SPINAL CORD; TIME FACTORS;

EID: 0343052945     PISSN: 10107940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1010-7940(97)00115-2     Document Type: Article

References (44)

1. Agee JM, Flanagan T, Blackbourne LH, Kron IL, Tribble CG. Reducing postischemic paraplegia using conjugated superoxide dismutase. Ann Thorac Surg 1991;591:911-5.
2. Bessler H, Gilgal R, Djaldetti M, Zahavi I. Effect of pentoxifylline on the phagocytic activity, cAMP levels and superoxide anion production by monocytes and polymorphonuclear cells. J Leukocyte Biol 1986;40:747-54.
3. Carlson DE, Karp RB, Kouchoukos NT. Surgical treatment of aneurysms of the descending thoracic aorta: an analysis of 85 patients. Ann Thorac Surg 1983;35:58-69.
4. Clark WM, Madden KP, Rothlein R, Zivin JA. Reduction of central nervous system ischemic injury in rabbits using leukocyte adhesion antibody treatment. Strok 1991;22:877-83.
5. Clark WM, Madden KP, Rothlein R, Zivin JA. Reduction of central nervous system ischemic injury by monoclonal antibody to intercelluler adhesion molecule. J Neurosurg 1991;75:623-7.
6. Crawford ES, Mizhari EM, Hess KR, Coselli JS, Safi HJ, Patel VM. The impact of distal aortic perfusion and somatosensory evoked potential monitoring on prevention of paraplegia after aortic aneurysm operation. J Thorac Cardiovasc Surg 1988;95:557-67.
7. Crawford ES, Svensson LG, Hess KR, Shenaq SS, Coselli JS, Safi HJ, Mohindra PK, Rivera V. A prospective randomized study of CSF drainage to prevent paraplegia after high-risk surgery on the thoracoabdominal aorta. J Vase Surg 1991;13:36-46.
8. Ehryly AM. The effect of pentoxifylline on flow properties of human blood. Curr Res Med Opin 1987;5:608-13.
9. Ehryly AM. The effect of pentoxifylline on the deformability of erythrocytes and on the muscular oxygen pressure in patients with chronic arterial disease. J Med 1979;10:331-8.
10. Engler RL, Dahlgren MD, Morris DD, Peterson MA, Schmid-Schonbein GW. Role of leukocytes in response to acute myocardial ischemia and reflow in dogs. Am J Physiol 1986;251:H314-22.
11. Forbes AD, Slimp JC, Winn RK, Verrier ED. Inhibition of neutrophil adhesion does not prevent ischemi spinal cord injury. Ann Thorac Surg 1994;58:1064-8.
12. Fowl RJ, Patterson RB, Gewirtz RJ, Anderson DK. Protection against postischemic spinal cord injury using a new 21-aminosteroid. J Surg Res 1990;48:597-600.
13. Gastpar H. New aspects of the pathogenesis of atherosclerosis: possible approaches to prevention and treatment. Cur Med Res Opin 1981;7:142-55.
14. Gelbfish JS, Phillips T, Rose DM, Wait R, Cunningham JN. Acute spinal cord ischemia: Prevention of paraplegia with verapamil. Circulation 1986;74(suppl):5-10.
15. Giulian D. Ameboid microglia as effectors of inflammation in the central nervous system. J Neurosci Res 1987;18:155-71.
16. Giulian D, Robertson C. Inhibition of mononuclear phagocytes reduces ischemic injury in the spinal cord. Ann Neurol 1990;27:33-42.
17. 1 and superoxide dismutase prevent ischaemic spinal cord injury after thoracic aortic cross-clamping? Eur Vase Surg 1990;4:19-24.
18. Hakim TS, Petrella J. Attenuation of pulmonary and systemic vasoconstriction with pentoxifylline and aminophylline. Can J Physiol Pharmacol 1988;66:396-401.
19. Harlen J. Leukocyte-endothelial interactions. J Am Soc Hematol 1985;65:513-25.
20. Jacobs TP, Shohami E, Baze W, Burgard E, Gunderson C, Hallenbeck JM, Feuerstein G. Deteriorating stroke model: histopathology, edema, and eicosanoid changes following spinal cord ischemi on rabbits. Stroke 1987;18:741-50.
21. Kouchoukos NT, Wareing TH, Izumoto H, Klausing W, Abbound N. Elective hypothermie cardiopulmonary bypass and circulatory arrest for spinal cord protection during operations on the thoracoabdominal aorta. J Thorac Cardiovasc Surg 1990;99:659-64.
22. Laschinger JC, Cunningham JN, Cooper MM, Krieger K, Nathan IM, Spencer FC. Prevention of ischemic spinal cord injury following aortic cross-clamping: Use of corticosteroids. Ann Thorac Surg 1984;38:500-7.
23. Laschinger JC, Izumoto H, Kouchoukos NT. Evolving concepts in prevention of spinal cord injury during operations on the descending thoracic and thoracoabdominal aorta. Ann Thorac Surg 1987;44:667-74.
24. Lawrence GH, Hessel EA, Sauvage LR, Krause AH. Results of the use of the TDMAC-heparin shunt in the surgery of aneurysms of the descending thoracic aorta. J Thorac Cardiovasc Surg 1977;78:393-8.
25. May IA, Ecker RR, Iverson LIG. Heparinless femoral venoarterial bypass without an oxygenator for surgery on the descending thoracic aorta. J Thorac Cardiovasc Surg 1977;73:387-92.
26. McCullough JL, Hollier LH, Nugent M. Paraplegia after thoracic aortic occlusion: Influence of cerebrospinal fluid drainage. J Vase Surg 1988;7;153-60.
27. Molina JE, Cogordan J, Einzig S, Bianco RW, Rasmussen T, Clack RM, Borgwardt B. Adequacy of ascending aorta-descending aorta shunt during cross-clamping of the thoracic aorta for prevention of spinal cord injury. J Thorac Cardiovasc Surg 1985;90:126-36.
28. Moore WM, Hollier LH. The influence of severity of spinal cord ischemia in the etiology of delayed-onset paraplegia. Ann Surg 1991;213:427-32.
29. Naslund TC, Hollier LH, Money SR, Facundus EC, Skenderis BS. Protecting the ischemic spinal cord during aortic clamping. Ann Surg 1992;215:409-16.
30. Nathan C, Murrey H, Cohn Z. The macrophages as an effector cell. N Engl J Med 1980;303:622-5.
31. Nylander WA, Plunkett RJ, Hammon JW, Oldfield EH, Meacham WF. Thiopental modification of ischemic spinal cord injury in the dog. Ann Thorac Surg 1982;33:64-8.
32. Oehmichen M. Inflammatory cells in the central nervous system. Prog Neuropathol 1983;5:277-335.
33. Porter JM, Cutler BS, Lee BY, Reich T, Reichle FA, Scogin JT, Strandness DE. Pentoxifylline efficacy in the treatment of intermittent claudication: multicenter controlled double blind trial with objective assessment of chronic occlusive arterial disease patients. Am Heart J 1982;104:66-72.
34. Robertson CS, Foltz R, Grossman RG, Goodman JC. Protection against experimental ischemic spinal cord injury. J Neurosurg 1986;64:633-42.
35. Romson J, Hook B, Lucchesi B. Reduction of extent of ischemic myocardial injury by neutrophil deplation in the dog. Circulation 1983;67:1016-23.
36. Schittek A, Bennink GB, Cooley DA, Langford LA. Spinal cord protection with intravenous nimodipine: a functional and morphologic evaluation. J Thorac Cardiovasc Surg 1992;104:1100-5.
37. Schmid-Schonbein G. Capillary plugging by granulocytes and the no-flow phenomenon in the microcirculation. FASEB 1987;46:2397-401.
38. Smith CW, Rothlein R, Hughes BJ, Mariscalco MM, Rudloff HE, Schmalstieg FC, Anderson DC. Recognition of an endothelial determinant for CD-18 dependent human neutrophil adherence and transendothelial migration. J Clin Invest 1988;82:1746-56.
39. Smith CW, Martin SR, Rothlein R, Toman C, Anderson DC. Cooperative interactions of LFA-1 and Mac-1 with intercelluler adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro. J Clin Invest 1989;83:2008-17.
40. Sullivan GW, Carper HT, Novick WL, Mandell GL. Inhibition of the inflammatory action of interleukin-1 and tumer necrosis factor (alpha) on neutrophil function by pentoxifylline. Infect Immune 1988;56:1722-9.
41. Svensson LG, Crawford ES, Hess KR, Coselli JS, Safi HJ. Experience with 1509 patients undergoing thoracoabdominal aortic operations. J Vase Surg 1993;17:357-70.
42. Svensson LG, Stewart RW, Cosgrove DM, Lytle BW, Antunes MD, Beven EG, Furtan AJ, Gottlieb A, Grum DF, Hinder RA. Intrathecal papaverine for the prevention of paraplegia after operation on the thoracic or thoracoabdominal aorta. J Thorac Cardiovasc Surg 1988;96:823-9.
43. Toung TJ, Kirsch JR, Maruki Y, Traystman RJ. Effects of pentoxifylline on cerebral blood flow, metabolism, and evoked response after total cerebral ischemia in dogs. Crit Care Med 1994;22:273-81.
44. Zimmerman G, McIntyre T. Neutrophil adherence to human endothelium in vitro occurs by CD-18 glycoprotein dependent and independent mechanism. J Clin Invest 1988;81:531-7.