Cerebral perfusion correlates of negative symptomatology and parkinsonism in a sample of treatment-refractory schizophrenics: An exploratory 99mTc-HMPAO SPET study

Schizophrenia Research

Volumn 25, Issue 1, 1997, Pages 11-20

  Molina Rodríguez, Vicente ^a,b,d   Montz Andrée, Richard ^c   Pérez Castejón, M José ^c   Gutiérrez Labrador, Rosa ^a,b   Ferre Navarrete, Francisco ^a,b   Carreras Delgado, J Luis ^c   Rubia Vila, F José ^b  

^a Centro de San Juan de Dios de Campozuelos   (Spain)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^c SCHOOL OF MEDICINE   (Spain)

^d INSTITUTO PLURIDISCIPLINAR   (Spain)

Author keywords

Negative symptoms; Perfusion; Schizophrenia; Single photon emission tomography

Indexed keywords

HEXAMETHYLPROPYLENE AMINE OXIME TECHNETIUM TC 99M;

ADULT; ARTICLE; BRAIN PERFUSION; BRAIN SCINTISCANNING; CLINICAL ARTICLE; HUMAN; MALE; PARKINSONISM; PRIORITY JOURNAL; SCHIZOPHRENIA; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SYMPTOMATOLOGY;

ADULT; ANTIPSYCHOTIC AGENTS; BRAIN; BRAIN MAPPING; CHRONIC DISEASE; DEPRESSION; DOMINANCE, CEREBRAL; HUMANS; MALE; MIDDLE AGED; ORGANOTECHNETIUM COMPOUNDS; OXIMES; PARKINSON DISEASE, SECONDARY; PSYCHIATRIC STATUS RATING SCALES; REGIONAL BLOOD FLOW; SCHIZOPHRENIA, PARANOID; TECHNETIUM TC 99M EXAMETAZIME; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TREATMENT FAILURE;

EID: 0343052802     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-9964(96)00115-6     Document Type: Article

References (63)

1. Andreasen, N.C., Narshallah, A., Dunn, V., Olson, S.C., Grove, W.M., Ehrhardt, J.C., Coffman, J.A. and Crosset, J.H.W. (1986) Structural abnormalities in the frontal system in schizophrenia. Arch. Gen. Psychiatry 43, 136-144.
2. Andreasen, N.C. and Olsen, S. (1982) Negative vs positive schizophrenia: definition and validation. Arch. Gen. Psychiatry 39, 789-794.
3. Andreasen, N.C. (1982) Negative symptoms in schizophrenia: definition and reliability. Arch. Gen. Psychiatry 39, 784-788.
4. Andreasen, N.C., Olsen, S.A., Dennert, J.W. and Smith, M.R. (1982) Ventricular enlargement in schizophrenia: relationship to negative and positive symptoms. Am. J. Psychiatry 139, 297-302.
5. Andreasen, N.C., Swayze, V.W., Flaum, M., Yates, W.R., Pahl, J.J., Arndt, S. and McChesney, C. (1990) Ventricular enlargement in schizophrenia evaluated with computed tomographic scanning: effects of gender, age and stage of illness. Arch. Gen. Psychiatry 47, 1008-1015.
6. Andreasen, N.C., Rezai, K., Alliger, R., Swayze, V.W. II, Flaum, M., Kirchner, P., Cohen, G. and O'Leary, D.S. (1992) Hypofrontality in neuroleptic naive patients and in patients with chronic schizophrenia. Assessment with Xenon 133 single photon emission computed tomography and the Tower of London. Arch. Gen. Psychiatry 49, 943-958.
7. Andreasen, N.C., Arndt, S., Alliger, Miller, D. and Flaum, M. (1995) Symptoms of schizophrenia. Methods, meanings and mechanisms. Arch. Gen. Psychiatry 52, 341-351.
8. Arndt, S., Andreasen, N.C., Flaum, M., Miller, D. and Nopoulos, P. (1995) A longitudinal study of symptom dimensions in schizophrenia. Predictions and patterns of change. Arch. Gen. Psychiatry 52, 352-360.
9. Barlett, E.J., Wolkin, A. and Brodie, J.D. (1991) Importance of pharmacologic control in PET studies: effects of thiothixene and haloperidol on cerebral glucose utilization in chronic schizophrenia. Psychiat. Res. 40, 115-124.
10. Barta, P.E., Pearlson, G.D., Powers, R.E., Richards, S.S. and Tune, L.E. (1990) Auditory hallucinations and smaller superior temporal gyral volume in schizophrenia. Am. J. Psychiatry 147, 1457-1462.
11. Berman, K.F., Torrey, E.F., Daniel, D.G. and Weinberger, D.R. (1989) Prefrontal cortical blood flow in monozygotic twins concordant and discordant for schizophrenia. Schizophr. Res. 2, 129-135.
12. Bogerts, B., Ashtari, M., Degreef, G., Alvir, J.M.J., Bilder, R.M. and Lieberman, J.A. (1990) Reduced temporal limbic structure volumes on magnetic resonance images in first episode schizophrenia. Psychiat. Res. 35, 1-13.
13. Buchsbaum, M.S., Wu J.C., DeLisi, L.E., Holcomb, H.H., Hazlett, E., Cooper-Langstom, K. and Kesslere, K. (1987) Positron emission tomography studies of basal ganglia and somatosensory cortex neuroleptic drug effects: differences between normal controls and schizophrenic patients. Biol. Psychiatry 22, 479-494.
14. Bustillo, J.R., Kirpatrick, B. and Buchanan, R.W. (1995) Neuroleptic treatment and negative symptoms in deficit and non-deficit schizophrenia. Biol. Psychiatry 38, 64-67.
15. Catafau, A.M., Parellada, E., Lomena, M.J., Bernardo, M., Pavía, J., Ros, D., Setoain, J. and González-Monclús, E. (1994) Prefrontal and temporal blood flow in schizophrenia: resting and activation technetium-99-m-HMPAO SPECT patterns in young neuroleptic-naive patients with acute disease. J. Nucl. Med. 35, 935-941.
16. Cleghorn, J.M., Garnett, E.S., Nahmias, G.M., Firnau, G., Brown, G.M., Kaplan, R., Szetchman, H. and Szetchman, B. (1989) Increased frontal and reduced parietal glucose metabolism in acute untreated schizophrenia. Psychiat. Res. 28, 119-133.
17. Cowell, P.E., Kostianovsky, D.J., Gur, R.C., Turetsky, B.I. and Gur, R.E. (1996) Sex differences in neuronatomical and clinical correlates in schizophrenia. Am. J. Psychiatry 153, 799-805.
18. DeLisi, L.E., Holcomb H.H., Cohen, R.M., Pickar, D., Carpenter, W.T., Morihisia, J.L., King, C., Kessler, R. and Buchsbaum, M.S. (1985) Positron emission tomography in schizophrenic patients with and without neuroleptic medication. J. Cereb. Blood Flow Metab. 5, 201-206.
19. DeLisi, L.E., Dauphinais, I.D. and Gerhson, E.S. (1988) Perinatal complications and reduced size of brain limbic structures in familial schizophrenia. Schizophr. Bull. 14, 185-191.
20. Ebmeier, K.P., Lawrie, S.M., Blackwood, D.H.R., Johnstone, E.G. and Goodwin, G.N. (1995) Hypofrontality revisited: a high resolution single photon emission computed tomography in schizophrenia J. Neurol. Neurosurg. Psychiatry 58, 452-456.
21. Gemmell, H.G., Evans, N.S.T. and Besson, J.A.O. (1990) Regional cerebral blood flow imaging: a quantitative comparison of technetium-99-m-HMPAO SPECT with C15-O2 PET. J. Nucl. Med. 31, 1595-1600.
22. Hammer, M.A., Katsanis, J. and Iacono, W.G. (1995) The relationship between negative symptoms and neuropsychological performance. Biol. Psychiatry 37, 828-830.
23. Katsanis, J. and Iacono, W.G. (1991) Clinical, neuropsychological and brain structural correlates of smooth pursuit tracking in chronic schizophrenia. J. Abnorm. Psychol. 100, 526-534.
24. Lewander, T. (1994) Neuroleptics and the neuroleptic-induced deficit syndrome. Acta Psychiatr. Scand. 89, 8-13.
25. Liddle, P.F., Friston K.J., Frith, C.D., Hirsch, S.R., Jones, T. and Frackowiak, R.S.J. (1992) Patterns of cerebral blood flow in schizophrenia. Br. J. Psychiatry 160, 179-186.
26. List, S.J. and Cleghorn, J.M. (1993) Implications of positron emission tomography research for the investigation of the actions of antipsychotic drugs. Br. J. Psychiatry 163 (Suppl. 22), 25-30.
27. Martin, P. and Albers, M. (1995) Cerebellum and schizophrenia: a selective review. Schizophr. Bull. 21, 241-250.
28. Molina, V., Montz, R., Pérez-Castejón, M.J., Capdevila, E., Carreras, J.L. and Rubia, F.J. (1996) SPECT study of regional cerebral perfusion in neuroleptic-resistant patients who responded or did not respond to clozapine. Am. J. Psychiatry 153, 1343-1346.
29. Minoshima et al. (1994) This reference appears in the text but not in the list.
30. Narshallah, H.A., Schwarzkopf, S.T., Olson, S.C. and Coffman, J.A. (1991) Perinatal brain injury and cerebellar lobules I-X in schizophrenia. Biol. Psychiatry 29, 567-574.
31. Nibuya, M., Kanba, S., Sekiya, U., Suzuki, E., Matsuo, Y., Kinishita, N., Shintani, F., Yagi, G. and Asai, M. (1995) Schizophrenic patients with deficit syndrome have higher plasma homovanilic acid concentrations and ventricular enlargement. Biol. Psychiatry 38, 50-56.
32. Nieuwenhuys, R., Voogd, J. and Van Huizen, C. (1988) The Human Central Nervous System: A Synopsis and Atlas, 3rd edn. Springer, New York.
33. Nyback, H., Wiesel, F.A., Bergreen, B.M. and Hindmarsh, T. (1982) Computed tomography in acute psychosis and healthy volunteers. Acta Psychiatr. Scand. 65, 403-414.
34. Oken, B.S. and Chiappa, K.H. (1986) Statistical issues concerning computerized analysis of brain wave topography. Ann. Neurol. 19, 493-494.
35. Ota, T., Maeshiro, H., Ishidiro, H., Shimuzu, R., Uchido, R., Tiyoshima, H., Ohshima, A., Taakazawa, A., Motomura, H. and Naguchi, T. (1987) Treatment-resistant chronic psychopathology and CT scans in schizophrenia. Acta Psychiatr. Scand. 415-427.
36. Pakkenberg, B. (1987) Postmortem study of chronic schizophrenic patients. Br. J. Psychiatry 151, 744-752.
37. Peralta, V., de León, J. and Cuesta, M.J. (1992) Are there more than two syndromes in schizophrenia? A critique of the positive-negative dichotomy. Br. J. Psychiatry 161, 335-343.
38. Quinlan, D.M., Schuldberg, D., Morgenstern, H. and Glazer, W. (1995) Positive and negative symptom course in chronic community based patients. Br. J. Psychiatry 166, 634-641.
39. Perlick, D., Mattis, S., Statsny, P. and Silverstein, B. (1992) Negative symptoms are related to both frontal and nonfrontal neuropsychological measures in schizophrenia. Arch. Gen. Psychiatry 49, 245.
40. Rifkin, A., Quitkin, F. and Klein, D.F. (1975) Akinesia: a poorly recognized drug-induced extrapyramidal behavioral disorder. Arch. Gen. Psychiatry 32, 672-674.
41. Roland, P.E., Larsen, B., Lassen, N.A. and Skinhøf, E. (1980) Supplementary motor area and other cortical areas in organization of voluntary movements in man. J. Neurophysiol. 43, 118-136.
42. Rossi, A., Stratta, P., Mancini, F., de Cataldo, S. and Cassachia, M. (1993) Cerebellar vermis size in schizophrenia: a male effect. Biol. Psychiatry 33, 354-357.
43. Rubin, P., Hemmingsen, R., Holm, S., Møller-Madsen, S., Hertel, C., Povlesen, J. and Karte, A. (1994) Relationship between brain structure and function in disorders of the schizophrenic spectrum: single photon emission computerized tomography, computerized tomography and psychopathology of first episodes. Acta Psychiatr. Scand. 90, 281-289.
44. Sandyk, R., Kay, S.R. and Meriam, A.E. (1991) Atrophy of the cerebellar vermis: relevance to the symptoms of schizophrenia. Int. J. Neurosci. 57, 205-212.
45. Schröder, J., Buchsbaum, M.S., Siegel, B.V., Geider, F.J. and Niethammer, R. (1995) Structural and functional correlates of subsyndromes in schizophrenia. Psychopathology 28, 38-45.
46. Siegel, B.V., Buchsbaum, M.S., Bunney, W.E., Gottschalk, L.A., Haier, R.H., Lohr, J.B., Lottenberg, S., Najali, A., Nuechterlein, K.H., Potkin, S.G. and Wu, J.C. (1993) Cortical-striatal-thalamic circuits and brain glucose metabolic activity in 70 unmedicated male schizophrenic patients. Am. J. Psychiatry 150, 1325-1336.
47. Stolar, N., Berembaum, H., Banich, M.T. and Barch, D. (1994) Neuropsychological correlates of alogia and affective flattening in schizophrenia. Biol. Psychiatry 35, 164-172.
48. Suddath, T.L., Casanova, M.F., Goldberg, T.E., Daniel, D.O., Kelsoe, J.R. and Weinberger, D.R. (1989) Temporal lobe pathology in schizophrenia: a quantitative magnetic resonance imaging study. Am. J. Psychiatry 146, 464-472.
49. Suddath, T.L., Christson, G.W., Torrey, E.F., Casanova, M.F. and Weinberger, D.R. (1990) Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia. N. Engl. J. Med. 322, 789-794.
50. Szetchzman, H.J., Nahmias, C., Garnett, E.S., Firnau, G., Brown, G.M., Kaplan, R.D. and Cleghorn, J.M. (1988) Effects of neuroleptics on altered cerebral glucose metabolism in schizophrenia. Arch. Gen. Psychiatry 45, 523-532.
51. Tamminga, C.A., Thaker, G.K., Buchanan, R., Kirpatrick, B., Alphs, L.D., Chase, T.N. and Carpenter, W.T. (1992) Limbic system abnormalities identified in schizophrenia using positron emission tomography with fluorodeoxyglucose and neocortical alterations with deficit syndrome. Arch. Gen. Psychiatry 49, 522-530.
52. Turkington, T.G., Jaszack, C.A., Pelizzari, C.A., Harris, C.C., McFall, J.R., Hoffman, J.M. and Coleman, E. (1993) Accuracy of registration of PET, SPECT and MR images of a brain phantom. J. Nucl. Med. 34, 1587-1594.
53. Turner, S.W., Toone, B.K. and Brett-Jones, J.R. (1986) Computerized tomographic scans changes in early chronic schizophrenia - their relationship to perinatal trauma, family history and alcohol intake: preliminary findings. Psychol. Med. 16, 219-223.
54. Vita, A., Bressi, S., Perani, D., Invernizzi, G., Giobbio, G.M., Dieci, M., Garbarini, M., DelSole, A. and Fazio, F. (1995) High resolution SPECT study of regional cerebral blood flow in drug-free and drug-naive schizophrenic patients. Am. J. Psychiatry 152, 8876-882.
55. Vita, A., Saccheti, E., Valvassori, G. and Cazullo, C.L. (1988) Brain morphology in schizophrenia: a 2-to 5-year CT scan follow-up study. Acta Psychiatr. Scand. 78, 618-621.
56. Volkow, N.D., Levy, A., Brodie, J.D., Wolf, A.P., Cancro, R., van Gelder, P. and Henn, F. (1992) Low cerebellar metabolism in medicated patients with chronic schizophrenia. Am. J. Psychiatry 149, 686-688.
57. Volkow, N.D., Wolf, A.P., van Gelder, P., Brodie, J.D., Overall, J.E., Cancro, R. and Gómez-Mont, F. (1987) Phenomenological correlates of metabolic activity in 18 patients with chronic schizophrenia. Am. J. Psychiatry 144, 151-158.
58. Wang, S.J., Liu, R.S. and Liu, H.C. (1993) Technetium-99m hexamethylpropilen-amine-oxyme SPET study of the brain in early Parkinson's disease: correlation with dementia and lateralization. Eur. J. Nucl. Med. 20, 339-344.
59. Weinberger, D.R., DeLisi, L.E., Perman, G.P., Targum, S. and Wyatt, R.J. (1982) Computed tomography in schizophreniform disorder and other acute psychiatric disorders. Arch. Gen. Psychiatry 39, 778-783.
60. Wiesel, F.A., Wik, G., Sjögren, I., Blompvist, G., Greitz, T. and Stone-Elander, S. (1987) Regional brain glucose metabolism in drug free schizophrenic patients and clinical correlates. Acta Psychiatr. Scand. 76, 628-641.
61. Wolkin, A., Jaeger, J., Brodie, J.D., Wolf, A.P., Fowler, J.S., Rotrosen, J., Gómez-Mont, F. and Cancro, R. (1985) Persistence of cerebral abnormalities in chronic schizophrenia as determined by positron emission tomography. Am. J. Psychiatry 142, 564-571.
62. Wolkin, A., Sanfilipo, M., Wolf, A.P., Angrist, B., Brodie, J.D. and Rotrosen, J. (1992) Negative symptoms and hypofrontality in chronic schizophrenia. Arch. Gen. Psychiatry 49, 959-965.
63. Wolkin, A., SanFilipo, M., Duncan, E., Angrist, B., Wolf, A.P., Cooper, T.B., Brodie, J.D., Laska, E. and Rotrosen, J.P. (1996) Blunted change in glucose utilization after haloperidol treatment in schizophrenic with prominent negative symptoms. Am. J. Psychiatry 153, 346-354.