Decreased blood level of β2-microglobulin in the employees of a factory which produced polychlorinated biphenyls

Chemosphere

Volumn 34, Issue 12, 1997, Pages 2595-2600

  Langer, P ^a   Kausitz J ^b   Tajtakova M ^c   Kocan A ^d   Bohov, P ^a   Hanzen, E ^e  

^a INSTITUTE OF EXPERIMENTAL ENDOCRINOLOGY   (Slovakia)

^b Oncology Institute of St Elizabeth   (Slovakia)

^c P J AFÁRIK UNIVERSITY   (Slovakia)

^d INST OF PREV AND CLINICAL MEDICINE   (Slovakia)

^e Institute of Clinical Endocrinology   (Slovakia)

Author keywords

2 microglobulin; Blood level; Human subjects; Polychlorinated biphenyls

Indexed keywords

BETA 2 MICROGLOBULIN; POLYCHLORINATED BIPHENYL; THYMIDINE KINASE;

ADULT; ARTICLE; BIOLOGICAL MONITORING; CONTROLLED STUDY; EMPLOYEE; FEMALE; HEALTH STATUS; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; OCCUPATIONAL EXPOSURE; OCCUPATIONAL HEALTH; PROTEIN BLOOD LEVEL; SLOVAKIA;

ADULT; ANALYSIS OF VARIANCE; BETA 2-MICROGLOBULIN; BIOLOGICAL MARKERS; CHEMICAL INDUSTRY; DEOXYURIDINE; FEMALE; HUMANS; IMMUNITY, CELLULAR; IMMUNOTOXINS; MALE; MIDDLE AGED; OCCUPATIONAL EXPOSURE; POLYCHLORINATED BIPHENYLS; RADIOIMMUNOASSAY; SLOVAKIA; THYMIDINE KINASE;

EID: 0343051876     PISSN: 00456535     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0045-6535(97)00102-1     Document Type: Article

References (27)

1. U.G. Ahlborg, A. Brouwer, M.A. Fingerhut, J.L. Jacobson, S.W. Jacobson, S.W. Kennedy, A.F.P. Kettrup, J.H. Koeman, H. Poiger, C. Rappe, S.H. Safe, R.F. Seegal, J. Tuomisto and M. van den Berg, Impact of polychlorinateddibenzo-p-dioxins, dibenzofurans, and biphenyls on human and environmental health, with special emphasis on application of the toxic equivalency factor concept. Eur. J. Pharmacol. 228,179-199(1992).
2. S.H. Safe, Polychlorinated biphenyls (PCBs): Environmental impact, biochemical and toxic responses, and implications for risk assessment. CRC Crit. Rev. Toxicol. 24,87-149(1994).
3. M. Boroush and M. Gough, Can cohort studies detect any human cancer excess that may result from exposure to dioxin? Maybe. Regul. Toxicol. Pharmacol. 20,198-210(1994).
4. G.M. Swanson, H.E. Ratcliffe and L.J. Fischer, Human exposure to polychlorinatedbiphenyls (PCBs): A critical assessment of the evidence for adverse health effects. Regul. Toxicol. Pharmacol. 21,136-150(1995).
5. W.J. Nicholson and P.J. Landrigan, Human health effects of polychlorinated biphenyls. In: Dioxins and Health (Edited by A. Schecter), pp.487-524. Plenum Press, New York (1994).
6. A. Kočan, J. Petrík, B. Drobná and J. Chovancová, Levels of PCBs and some organochlorine pesticides in the human population of selected areas of the Slovak Republic. I. Blood. Chemosphere 29:2315-2315(1994).
7. A. Kočan, J. Petrík, J. Chovancová, B. Drobná and H. Uhrinová: Chlorinated aromatic compounds in the human organism from selected model areas of the Slovak Republic (in Slovak), Research Report, Institute of Preventive and Clinical Medicine, Bratislava (1995)
8. A. Kočan, D.G. Patterson, Jr., J. Petrík, W.E. Turner, J. Chovancová and B. Drobná, PCDD, PCDF and coplanar PBC levels in blood from the human population of the Slovak Republic. In: Human Exposure - Human Health Risk Assessment (Edited by M. van den Berg et al.), pp.137-142, University of Amsterdam, Amsterdam (1996).
9. L.S. Birnbaum, The mechanism of dioxin toxicity: Relationship to risk assessment. Environ. Health Perspect. 102(Suppl 9), 157-167(1994).
10. A. Schecter, P. Furst, C. Furst, O. Papke, M. Ball, J.J. Ryan, H.D. Cau, L.C. Dai, Q.T. Quynh, H.Q. Cuong, N.T.N. Phuong, P.H. Phiet, A. Beim, J. Constable, J. Startin, M. Samedy and Y.K., Chlorinated dioxins and dibenzofurans in human tissue from general population; A selective review. Environ. Health Perspect. 102(Suppl 1),159-171(1994).
11. S. Skerfving, B.G. Swensson, L. Asplund and L. Hagmar, Exposure to mixtures and congeners of polychlorinated biphenyls. Clin. Chem. 40,1409-1415(1994).
12. F. Matsumura, Mechanism of action of dioxin-type chemicals, pesticides, and other xenobiotics affecting nutritional indexes. Am. J. Clin. Nutr. 61(Suppl),695S-701S(1995).
13. 2-microglobulin: the constant chain of HLA antigens. Eur. J. Clin. Invest. 10,293-300(1980).
14. 2-microglobulin in serum of adult T cell leukemia. Leukemia 9,594-597(1995).
15. 2-microglobulin in chronic diseases of the pancreas. Internat. J. Pancreatol. 17,161-166(1995).
16. 2-microglobulin is induced by treatment in Pneumocystis carinii pneumonia. J. Infect. Dis. 169,1170-1173(1994).
17. M. Liu, J.L. Fahey, N. Aziz, W.G. Cumberland, G. Skowron and T. Merigan, Zidovudine and dideoxycytidine differ in their effects on human immunodeficiency virus-induced pathologic activation of the immune system. J. Infect. Dis. 170,1165-1171(1994).
18. W.A O'Brien, P.M. Hartigan, D. Martin, J. Esinhart, A. Hill, S. Benoit, M.S. Rubin and J.D. Hamilton, Changes in plasma HIV-1 RNA and CD4+ lymphocyte counts and the risk of progression to AIDS. N. Eng. J. Med. 334,426-431(1996).
19. Multicohort Analysis Project Workshop. Part II. AIDS 8,923-933(1994).
20. M.P. Holsapple, D.L. Morris, S.C. Wood and N.K. Snyder, 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducedchanges in immunocompetence: Possible mechanisms. Ann. Rev. Pharmacol. Toxicol. 31,83-100(1991).
21. L.S. Birnbaum, Workshop on perinatal exposure to dioxin-like compounds. V. Immunologic effects. Environ. Health Perspect. 103(Suppl 2),157-169(1995).
22. N.I. Kerkvliet, Immunological effects of chlorinated dibezo-p-dioxins.Environ. Health Perspect. 103(Suppl 9),47-53(1995).
23. J.G. Vos JG, H. Van Loveren, Markers for immunotoxic effect in rodents and man. Toxicol. Lett. 82/83,385-394(1995).
24. T. Vial, B. Nicolas, J. Descotes, Clinical immunotoxicity of pesticides, J. Toxicol. Environ. Health 48,215-229(1996)
25. E. Devailly, P. Ayotte, S. Bruneau, C. Laliberte, D.C.G. Muir, R.J., Inuit exposure to organochlorine through the aquatic food chain in arctic Quebec. Environ. Health Perspect. 101,618-629(1993).
26. K.J. Chang, K.H. Hsieh, T.P. Lee, S.Y. Tang and T.C. Tung, Immunologic evaluation of patients with polychlorinated biphenyl poisoning: determination of lymphocyte subpopulations. Toxicol. Appl. Pharmacol. 61,58-63(1981).
27. A. Zober, M.G. Ott and P. Messerer, Morbidity follow up study of BASF employees exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD) after a 1953 chemical reactor incident. Occup. Environ. Med. 51,479-486(1994).