Opioid peptides inhibit the estradiol-induced proliferation of cultured rat uterine cells

European Journal of Pharmacology

Volumn 336, Issue 1, 1997, Pages 65-70

  Környei, József L ^a   Vértes, Zsuzsanna ^a   Oszter, Angéla ^a   Kovács, Sándor ^a   Vértes, Marietta ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

Author keywords

Cell culture; Estradiol; Opioid; Proliferation; Rat; Uterus

Indexed keywords

ENKEPHALINAMIDE[2 DEXTRO METHIONINE 5 PROLINE]; ESTRADIOL; MU OPIATE RECEPTOR; NALOXONE; OPIATE; OPIATE ANTAGONIST;

ANIMAL TISSUE; ARTICLE; CELL CULTURE; CONTROLLED STUDY; FEMALE; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; RAT; SEXUAL MATURITY; STIMULATION; UTERUS; UTERUS GROWTH;

AGE FACTORS; ANIMALS; CELL DIVISION; CELLS, CULTURED; ENKEPHALIN, METHIONINE; ESTRADIOL; ESTRADIOL ANTAGONISTS; FEMALE; NALOXONE; NARCOTIC ANTAGONISTS; RATS; UTERUS;

EID: 0343036191     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)01153-9     Document Type: Article

References (44)

1. Abou-Issa H., Tejwani G.A. Antitumor activity of naltrexone and correlation with steroid hormone receptors. Biochem. Biophys. Res. Commun. 175:1991;625-630.
2. Astrahantseff K.N., Morris J.E. Estradiol-17 beta stimulates proliferation of uterine epithelial cells cultured with stromal cells but not cultured separately. In Vitro Cell. Dev. Biol. Animal. 30:1994;769-776.
3. 3H -naloxone binding Peptides. 6:1985;971-974.
4. Barg J., Nah S.Y., Levy R., Saya D., Vogel Z. Modulation of thymidine incorporation by kappa-opioid ligands in rat spinal cord-dorsal root ganglion co-cultures. Brain Res. 629:1993;109-114.
5. 2+ mobilization in rat C6 glioma cells. J. Neurosci. 14:1994;5858-5864.
6. Belcheva M., Barg J., Rowinski J., Clark W.G., Gloeckner C.A., Ho A., Gao X.M., Chuang D.M., Coscia C. Novel opioid binding sites associated with nuclei of NG108-15 neurohybrid cells. J. Neurosci. 13:1993;104-114.
7. Borras M., Hardy L., Lempereur F., Elkhissiin A.H., Legros N., Golwinkler R., Leclercq G. Estradiol-induced down-regulation of estrogen receptor - Effect of various modulators of protein synthesis and expression. J. Steroid Biochem. Mol. Biol. 48:1994;325-336.
8. Davila-Garcia M.I., Azmitia E.C. Neuropeptides as positive or negative neuronal growth regulatory factors: Effects of ACTH and leu-enkephalin on cultured serotonergic neurons. Adv. Exp. Med. Biol. 265:1990;75-92.
9. Dowdy, S., Wearden, S., 1983. Statistics for Research. John Wiley & Sons Inc., New York.
10. Ferin M., VanVugt D., Wardlaw S. The hypothalamic control of the menstrual cycle and the role of endogenous opioid peptides. Rec. Prog. Horm. Res. 40:1984;441-485.
11. 3H -oestradiol to nuclear type II binding sites of rat uterus and hypothalamus J. Steroid Biochem. Mol. Biol. 32:1989;433-438.
12. Genazzani A.R., Petraglia F. Opioid control of luteinizing hormone secretion in humans. J. Steroid Biochem. Mol. Biol. 33:1989;751-755.
13. Hatzoglou A., Bakogeorgou E., Castanas E. The antiproliferative effect of opioid receptor agonists on the T47D human breast cancer cell line, is partially mediated through opioid receptors. Eur. J. Pharmacol. Mol. Pharm. 296:1996;199-207.
14. Hytrek S.D., McLaughlin P.J., Lang C.M., Zagon I.S. Inhibition of human colon cancer by intermittent opioid receptor blockade with naltrexone. Cancer Lett. 101:1996;159-164.
15. Hytrek S.D., Smith J.P., McGarrity T.J., McLaughlin P.J., Lang C.M., Zagon I.S. Identification and characterization of zeta-opioid receptor in human colon cancer. Am. J. Physiol. Regul. Integr. C. 40:1996;R115-R121.
16. Jin D.F., Muffly K.E., Okulicz W.C., Kilpatrick D.L. Estrous-cycle- and pregnancy-related differences in expression of the proenkephalin and proopiomelanocortin genes in the ovary and uterus. Endocrinology. 122:1988;1466-1471.
17. Környei J.L., Lei Z.M., Rao C.V. Human myometrial smooth muscle cells are novel targets of direct regulation by human chorionic gonadotropin. Biol. Reprod. 49:1993;1149-1157.
18. Környei J.L., Li X., Lei Z.M., Rao C.V. Restoration of human chorionic gonadotropin response in human myometrial smooth muscle cells by treatment with follicle-stimulating hormone (FSH): Evidence for the presence of FSH receptors in human myometrium. Eur. J. Endocrinol. 134:1996;225-231.
19. Li W.I., Sung L.C., Bazer F.W. Immunoreactive methionin-enkephalin secretion by porcine uterus. Endocrinol. 128:1991;21-26.
20. Low K.G., Nielsen C.P., West N.B., Douglass J., Brenner R.M., Maslar I.A., Melner M.H. Proenkephalin gene expression in the primate uterus: Regulation by estradiol in the endometrium. Mol. Endocrinol. 3:1989;852-857.
21. Maneckjee R., Biswas R., Vonderhaar B.K. Binding of opioids to human MCF-7 breast cancer cells and their effects on growth. Cancer Res. 50:1990;2234-2238.
22. Markaverich B.M., Upchurch S., McCormack S.A., Glasser S.R., Clark J.H. Differential stimulation of uterine cells by nafoxidine and clomiphene: Relationship between nuclear estrogen receptors and type II estrogen binding sites and cellular growth. Biol. Reprod. 24:1981;171-181.
23. McCormack S.A., Glasser S.R. Differential response of individual uterine cell types from immature rats treated with estradiol. Endocrinology. 106:1980;1634-1649.
24. Muffly K.E., Jin D.F., Okulicz W.C., Kilpatrick D.L. Gonadal steroids regulate proenkephalin gene expression in a tissue-specific manner within the female reproductive system. Mol. Endocrinol. 2:1988;979-984.
25. Mukherjee D., Manna P.R., Bhattacharya S. Functional relevance of luteinizing hormone receptor in mouse uterus. Eur. J. Endocrinol. 131:1994;103-108.
26. Nardulli A.M., Katzenellenbogen B.S. Dynamics of estrogen receptor turnover in uterine cells in vitro and in uteri in vivo. Endocrinology. 119:1986;2038-2046.
27. Ördög T., Vértes Z., Vértes M. Inhibition of oestradiol-induced DNA synthesis by opioid peptides in the rat uterus. Life Sci. 51:1992;1187-1196.
28. Ördög T., Vértes Z., Vértes M. Role of endogenous opioids in progesterone antagonism on oestradiol-induced DNA synthesis in the rat uterus. J. Steroid Biochem. Mol. Biol. 45:1993;455-457.
29. Petraglia F., Segre A., Fachinetti F., Campanini D., Ruspa M., Genazzani A.R. Beta-endorphin and met-enkephalin in peritoneal and ovarian follicular fluids of fertile and postmenopausal women. Fertil. Steril. 44:1985;615-620.
30. Radulovic J., Miljevic C., Djergovic D., Vujic V., Antic J., Vonhorsten S., Jankovic B.D. Opioid receptor-mediated suppression of humoral immune response in vivo and in vitro: Involvement of kappa opioid receptors. J. Neuroimmunol. 57:1995;55-62.
31. 5-enkephalinamide. J. Pharm. Pharmacol. 33:1981;534-535.
32. Szücs M., Bem W.T., Yeung S.C.J., Coscia C.J. Characterization of intracellular opioid binding sites and G regulatory proteins in neonatal and adult rat brain. Eur. J. Pharmacol. 183:1990;2311.
33. 5-enkephalinamide treatment on the DNA synthesis in the developing rat brain. Life Sci. 31:1982;49-54.
34. Vértes M., Pámer Z., Garai J. On the mechanism of opioid-oestradiol interactions. J. Steroid Biochem. Mol. Biol. 24:1986;235-238.
35. 3H -naloxone binding in oestrogen stimulated rat uterus J. Steroid Biochem. Mol. Biol. 46:1993;819-825.
36. Vértes Z., Környei J.L., Kovács S., Vértes M. Nuclear [H-3]naloxone binding in rat hypothalamus. Neuroreport. 6:1995;2385-2388.
37. Vértes Z., Környei J.L., Kovács S., Vértes M. Role of opioid peptides in the regulation of DNA synthesis in immature rat uterus. Eur. J. Pharmacol. Mol. Pharm. 291:1995;115-120.
38. Vértes Z., Környei J.L., Kovács S., Vértes M. Opioids regulate cell proliferation in the developing rat uterus: Effects during the period of sexual maturation. J. Steroid Biochem. Mol. Biol. 59:1996;173-178.
39. Wahlström T., Laatikainen T., Salminen K., Leppaluoto J. Immunoreactive β-endorphin is demonstrable in the secretory but not in the proliferative endometrium. Life Sci. 36:1985;987-990.
40. Wittert G., Hope P., Pyle D. Tissue distribution of opioid receptor gene expression in the rat. Biochem. Biophys. Res. Commun. 218:1996;877-881.
41. Zagon I.S., McLaughlin P.J. Endogenous opioids and the growth regulation of a neural tumor. Life Sci. 43:1988;1313-1318.
42. Zagon I.S., McLaughlin P.J. Zeta, a growth-related opioid receptor in developing rat cerebellum: Identification and characterization. Brain Res. 551:1991;28-35.
43. Zagon I.S., Wu Y., McLaughlin P.J. Opioid growth factor inhibits DNA synthesis in mouse tongue epithelium in a circadian rhythm-dependent manner. Am. J. Physiol. 267:1994;R645-R652.
44. Zagon I.S., Wu Y., McLaughlin P.J. The opioid growth factor, [Met(5)]-enkephalin, and the zeta (Zeta) opioid receptor are present in human and mouse skin and tonically act to inhibit DNA synthesis in the epidermis. J. Invest. Dermatol. 106:1996;490-497.