Moclobemide fatalities: Report of two cases and analytical determinations by GC-MS and HPLC-PDA after solid-phase extraction

Forensic Science International

Volumn 87, Issue 3, 1997, Pages 239-248

  Gaillard, Yvan ^a   Pépin, Gilbert ^a  

^a Laboratoire d'Expertises TOXLAB   (France)

Author keywords

Death; GC MS; HPLC PDA; Moclobemide

Indexed keywords

BROMAZEPAM; CLOMIPRAMINE; MOCLOBEMIDE; VILOXAZINE; ZOLPIDEM;

ACCURACY; ADULT; ARTICLE; BLOOD ANALYSIS; CALIBRATION; CASE REPORT; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG FATALITY; DRUG INTOXICATION; DRUG OVERDOSE; DRUG URINE LEVEL; FEMALE; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN TISSUE; MASS SPECTROMETRY; PRIORITY JOURNAL; URINALYSIS;

EID: 0343035733     PISSN: 03790738     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0379-0738(97)00075-3     Document Type: Article

References (9)

1. F. A Wiesel, J. Raaflaub, R. Kettler, Pharmacokinetics of oral moclobemide in healthy human subjects and effects on MAO activity in platelets and excretion of urine monoamine metabolites. Eur. J. Clin. Pharmacol. 28 (1985) 89-95.
2. I. Schweitze, J. Tiller, K. Maguire, B. Davies, Treatment of atypical depression with moclobemide: a sequential double controlled study. Int. J. Clin. Pharmacol. Resp. 9 (1989) 111-117.
3. W.P. Burkard, E.P. Bonetti, M. DaPrada, J.R. Martin, P. Polc, R. Schaffner, R. Scherschlicht, F. Hefti, R.K.M. Muller, P. C. Wyss, W. Haefely, Pharmacological profile of moclobemide, a short acting and reversible inhibitor of monoamine oxidase type A. J. Pharmacol. Exp. Ther. 248 (1989) 391-399.
4. J. Raaflaub, P. Haefelfinger, K.H. Trautman, Single dose pharmacokinetics of the MAO inhibitor moclobemide in man. Artzneimittelforsch. 34 (1984) 80-82.
5. Y. Gaillard, G. Pépin, Use of photodiode array UV detection for the creation of a 600-compound library. Application to forensic toxicology. J. Chromatogr. A, 763 (1997) 149-163.
6. A.B.J. Nix, D.W. Wilson, Assay detection limits: concept, definition, and estimation. Eur. J. Clin. Pharmacol. 39 (1990) 203-206.
7. K. Gautschi, B. Keller, H. Keller, P. Pei, D.J. Vonderschmitt, A new look at the detection, quantification and power of definition limits. Eur. Clin. Chem. Clin. Biochem. 31 (1993) 433-440.
8. Y. Gaillard, J.P. GayMontchamp, M. Ollagnier, Simultaneous screening and quantitation of alpidem, zolpidem, buspirone and benzodiazepines by dual channel gas chromatography using electron capture and nitrogen phosphorus detection after solid-phase extraction. J. Chromatogr. 622 (1993) 197-208.
9. J.N. Edwards, M. Glen-Bott, Does viloxazine have epileptogenic properties?. J. Neurol. Neurosurg. Psychiatry 47 (1984) 960-964.