Peripheral NMDA receptors contribute to activation of nociceptors: A c-fos expression study in rats

Neuroscience Letters

Volumn 221, Issue 2-3, 1997, Pages 101-104

  Wang, H ^a   Liu, R J ^a   Zhang, R X ^a   Qiao, J T ^a  

^a SHANXI MEDICAL UNIVERSITY   (China)

Author keywords

c fos expression; N methyl D aspartate MK 801; peripheral N methyl D aspartate receptor; peripheral nociception; rats

Indexed keywords

DIZOCILPINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; IMMUNOCYTOCHEMISTRY; MALE; NOCICEPTIVE RECEPTOR; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; RAT; SPINAL CORD DORSAL HORN; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; FEMALE; MALE; N-METHYLASPARTATE; NOCICEPTORS; PRESYNAPTIC TERMINALS; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; SPINAL CORD;

EID: 0343035696     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(96)13299-7     Document Type: Article

References (22)

1. Aanonsen, L.M., Lei, S. and Wilcox, G.L., Excitatory amino acid receptor and nociceptive neurotransmission in rat spinal cord, Pain, 41 (1990) 309-321.
2. Birder, L.A. and de Groat, W.C., Increased c-fos expression in spinal neurons after irritation of the lower urinary tract in the rat, J. Neurosci., 12 (1992) 4878-4889.
3. Cahusac, P.M.B., Evans, R.H., Hill, R.G., Rodriquez, R.E. and Smith, D.A.S., The behavioral effects of a N-methylasparatate receptor antagonist following application to the lumbar spinal cord of conscious rats, Neuropharmacology, 23 (1984) 719-724.
4. Carlton, S.M. and Hargett, G.L., Treatment with the NMDA antagonist memantine attenuates nociceptive responses to mechan-ical stimulation in neuropathic rats, Neurosci. Lett., 198 (1995) 115-118.
5. Chirstensen, B.N. and Perl, E.R., Spinal neurons specifically excited by noxious or thermal stimuli: marginal zone of the dorsal horn, J. Neurophysiol., 33 (1970) 293-307.
6. Cincotta, M., Beart, P., Summers, R.J. and Lodge, D., Bidirectional transport of NMDA receptor and ionophore in the vagus nerve, Eur. J. Pharmacol., 160 (1989) 167-171.
7. Curtis, D.R., Phillis, J.W. and Watkins, J.C., Chemical excitation of spinal neurons, Nature, 183 (1959) 611-612.
8. De Biasi, S. and Rustioni, A., Glutamate and substance P coexist in primary afferent terminals in the superficial laminae of spinal cord, Proc. Natl. Acad. Sci. USA, 85 (1988) 7820-7824.
9. Dubner, R. and Basbaum, A.I., Spinal dorsal horn plasticity following tissue or nerve injury. In P.D. Wall and R. Melzack (Eds.), Textbook of Pain, 3rd edn., Churchill Livingstone, London, 1994, pp. 225-241.
10. Erik, H.F., Wong, J.A., Kemp, T.P., Antony, R.K., Geoffrey, N.W. and Leslie, L.I., The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist, Proc. Natl. Acad. Sci. USA., 83 (1986) 7104-7108.
11. Hsu, S.M., Raind, L. and Fanger, H., Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase technique. A comparison between ABC and unlabeled antibody (PAP) procedures, J. Histochem. Cytochem., 29 (1981) 577-580.
12. Hunt, S.P., Pini, A. and Evan, G., Induction of c-Fos-like protein in the spinal cord neurons following sensory stimulation, Nature, 328 (1987) 632-634.
13. Jackson, D.L., Graff, C.B., Richardson, J.D. and Hargreaves, K.M., Glutamate participates in the peripheral modulation of thermal hyperalgesia in rats, Eur. J. Pharmacol., 284 (1995) 321-325.
14. Kehl, L.J., Cogas, K.R., Lichtblau, L.L., Pollock, C.H., Mayes, M., Basbaum, A.I. and Wilcox, G.L., The NMDA antagonist MK-801 reduces noxious stimulus-evoked FOS expression in the spinal cord dorsal horn, Proceeding of the VIth World Congress on Pain, Elsevier, Amsterdam, 1991, pp. 307-311.
15. Liu, H., Wang, H., Sheng, M., Jan, L.Y., Jan, Y.N. and Basbaum, A.I., Evidence for presynaptic N-methyl-D-aspartate autoreceptors in the spinal cord dorsal horn, Proc. Natl. Acad. Sci. USA, 91 (1994) 8383-8387.
16. Richard, A.M., James, N.C. and Srinivasa, N.R., Peripheral neural mechanisms of nociception. In P.D. Wall and R. Melzack (Eds.), Textbook of Pain, 3rd edn., Churchill Livingstone, London, 1994, pp. 13-44.
17. Sato, K., Kiyama, H., Park, H.P. and Tohyama, M., AMPA, KA and NMDA receptor are expressed in the rat DRG neurons, NeuroReport, 4 (1993) 1263-1265.
18. Shigemoto, R., Ohisi, H., Nakanishi, S. and Mizuno, N., Expression of the mRNA for the rat NMDA receptor(NMDAR1) in the sensory and autonomie ganglion neurons, Neurosci. Lett., 144 (1992) 229-232.
19. Shu, S., Ju, G. and Fan, L., The glucose oxidase-DAB-nickel method in peroxidase histochemistry of the nervous system, Neurosci. Lett., 85 (1988) 169-171.
20. Tolle, T.R., Castro-Lopes, J.M., Evan, G. and Zieglgansberger, W., c-fos Induction in the spinal cord following noxious stimulation: prevention by opiates but not by NMDA antagonists, Proceedings of the Vlth World Congress on Pain, Elsevier, Amsterdam, 1991, pp. 299-305.
21. Wilcox, G.L., Excitatory neurotransmitters and pain, Proceedings of Vlth World Congress on Pain, Elsevier, Amsterdam, 1991, pp. 97-117.
22. Zhang, R.X., Wang, R., Chen, J.Y. and Qiao, J.T., Effects of descending inhibitory systems on the c-fos expression in the rat spinal cord during formalin-induced noxious stimulation, Neuroscience, 58 (1994) 229-304.