Genetically Evolved Receptor Models (GERM) as a 3D QSAR Tool

Perspectives in Drug Discovery and Design

Volumn 12, Issue , 1998, Pages 159-166

  Walters, D Eric ^a  

^a ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0343005852     PISSN: 09282866     EISSN: None     Source Type: Journal    
DOI: 10.1023/a:1017038206129     Document Type: Article

References (7)

1. Walters, D.E. and Hinds, R.M., Genetically evolved receptor models: A computational approach to construction of receptor models, J. Med. Chem., 37 (1994) 2527-2536.
2. Walters, D.E. and Muhammad, T.D., Genetically evolved receptor models (GERM): A procedure for construction of atomic-level receptor site models in the absence of a receptor crystal structure, In Devillers, J. (Ed.) Genetic algorithms in drug design, Academic Press, London, 1996, pp. 193-210.
3. Holland, J.H., Adaptation in natural and artificial systems, University of Michigan Press, Ann Arbor, MI, 1975.
4. Brooks, B.R., Bruccoleri, R.E., Olafson, B.D., States, D.J., Swaminathan, S. and Karplus, M., CHARMM: A program for macromolecular energy minimization and dynamics calculations, J. Comput. Chem., 4 (1983) 187-217.
5. Culberson, J.C. and Walters, D.E., Development and utilization of a three-dimensional model for the sweet taste receptor, In Walters, D.E., Orthoefer, F.T. and DuBois, G.E. (Eds.) Sweeteners: Discovery, molecular design and chemoreception, American Chemical Society, Washington, DC, 1991, pp. 214-223.
6. DuBois, G.E., Walters, D.E., Schiffman, S.S., Warwick, Z.S., Booth, B.J., Pecore, S.D., Gibes, K., Carr, B.T. and Brands, L.M., A systematic study of concentration-response relationships of sweeteners, In Walters, D.E., Orthoefer, F.T., and Dubois, G.E. (Eds.) Sweeteners: Discovery molecular design and chemoreception, American Chemical Society, Washington, DC, 1991, pp. 261-276.
7. Walters, D.E. and Muhammad, T.D., Genetically evolved receptor models (GERM): A comparison of evolved models with crystallographically determined binding sites. In Liljefors, T., Jørgensen, F.S., and Krogsgaard-Larsen, P. (Eds.) Rational molecular design in drug research, Munksgaard, Copenhagen, 1998 (in press).