Sorting of Proteins to the Mitochondrial Intermembrane Space

Advances in Molecular and Cell Biology

Volumn 17, Issue C, 1996, Pages 193-220

  Stuart, Rosemary A ^a   Fölsch, Heike ^a   Gruhler, Albrecht ^a   Neupert, Walter ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0342997446     PISSN: 15692558     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1569-2558(09)60015-1     Document Type: Article

References (78)

1. 2. NATO ASI Series 71 (1993) 223-233
2. 2 to the mitochondrial intermembrane space contains three distinct functional regions. EMBO J. 12 (1993) 2303-2311
3. Behrens M., Michaelis G., and Pratje E. Mitochondrial inner membrane protease 1 of Saccharomyces cerevisiae shows sequence similarity to the Escherichia coli leader peptidase. Mol. Gen. Genet. 228 (1991) 167-176
4. Blobel G. Intracellular protein topogenesis. Proc. Natl. Acad. Sci. USA 77 (1980) 1496-1500
5. Blom J., Kübrich M., Rassow J., Voos W., Dekker P.J.T., Maarse A.C., Meijer M., and Pfanner N. The essential yeast protein MIM44 (encoded by MPII) is involved in an early step of preprotein translocation across the mitochondrial inner membrane. Mol. Cell. Biol. 13 (1993) 7364-7371
6. Cheng M.Y., Hartl F.-U., Martin J., Pollock R.A., Kalousek F., Neupert W., Hallberg E.M., Hallberg R.L., and Horwich A.L. Mitochondrial heat shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria. Nature 337 (1989) 620-625
7. Cyr D.M., Stuart R.A., and Neupert W. A matrix ATP requirement for presequence translocation across the inner membrane of mitochondria. J. Biol. Chem. 268 (1993) 23751-23754
8. Dekker P.J.T., Keil P., Rassow J., Maarse A.C., Pfanner N., and Meijer M. Identification of MIM23, a putative component of the protein import machinery of the mitochondrial inner membrane. FEBS Lett. 330 (1993) 66-70
9. Drygas M.E., Labowitz A.M., and Nargang F.E. Cloning and analysis of the Neurospora crassa gene for cytochrome c heme lysase. J. Biol. Chem. 264 (1989) 17897-17907
10. Dumont M.E., Ernst J.F., and Sherman F. Coupling of heme attachment to import of cytochrome c into yeast mitochondria. J. Biol. Chem. 263 (1988) 15928-15930
11. Dumont M.E., Cardillo T.S., Hayes M.K., and Sherman F. Role of cytochrome c heme lyase in mitochondrial import and accumulation of cytochrome c in S. cerevisiae. Mol. Cell. Biol. 11 (1991) 5487-5496
12. Emtage J.L.T., and Jensen R.E. MAS 6 encodes an essential inner membrane component of the yeast mitochondrial protein import pathway. J. Cell Biol. 122 (1993) 1003-1012
13. 1 complex into yeast mitochondria. J. Biol. Chem. 265 (1990) 16541-16547
14. Gambill B.D., Voos W., Kang P.J., Miao B., Langer T., Craig E.A., and Pfanner N. A dual role for miochondrial heat shock protein 70 in membrane translocation of preproteins. J. Cell. Biol. 123 (1993) 109-118
15. Glick B.S., Beasley E.M., and Schatz G. Protein sorting in mitochondria. Trends Biochem. Sci. 17 (1992) 453-459
16. 2 are sorted to the intermembrane space of yeast mitochondria by a stop-transfer mechanism. Cell 69 (1992) 809-822
17. 2 to the mitochondrial intermembrane space: The tightly folded heme-binding domain makes import dependent upon matrix ATP. Protein Sci. 2 (1993) 1901-1917
18. Grivell L.A. Nucleo-mitochondrial interactions in yeast mitochondrial biogenesis. Eur. J. Biochem. 182 (1989) 477-493
19. 2 into mitochondria: evidence for conservative sorting. EMBO J. 14 (1995) 1349-1359
20. 2). EMBO J. 4 (1985) 3265-3272
21. Hallberg E.M., Shu Y., and Haliberg R.L. Loss of mitochondrial hsp60 function: Nonequivalent effects on matrix-targeted and intermembrane psace targeted proteins. Mol. Cell. Biol. 13 (1993) 3050-3057
22. Hartl F.-U., Schmidt B., Wachter E., Weiss H., and Neupert W. Transport into mitochondria and intramitochondrial sorting of the Fe/S protein of the ubiquinol-cytochrome c reductase. Cell 47 (1986) 939-951
23. Hartl F.-U., Ostermann J., Guiard B., and Neupert W. Successive translocation into and out of the mitochondrial matrix: Targeting of proteins to the intermembrane space by a bipartite signal peptide. Cell 51 (1987) 1027-1037
24. Hartl F.-U., and Neupert W. Protein sorting to mitochondria: Evolutionary conservations of folding and assembly. Science 247 (1990) 930-938
25. Höhfeld J., and Hartl F.-U. Requirement of the chaperonin cofactor Hspl0 for protein folding and sorting in yeast mitochondria. J. Cell. Biol. 126 (1994) 305-315
26. Hwang S.T., and Schatz G. Translocation of proteins across the mitochondrial inner membrane, but not the outer membrane, requires nucleoside triphosphates in the matrix. Proc. Natl. Acad. Sci. USA 86 (1989) 8432-8436
27. Ikeda E., Yoshida S., Mitsuzawa H., Uno I., and Toh-e A. YGE is a yeast homologue of Escherichia coli grpE and is required for maintenance of mitochondrial functions. FEBS Lett. 39 (1994) 265-268
28. Isaya G., Kalousek F., and Rosenberg L.E. Sequence analysis of rat mitochondrial intermediate peptidase: Similarity to zinc metallopeptidases and a putative yeast homologue. Proc. Natl. Acad. Sci. USA 89 (1992) 8317-8321
29. 1 presequence prevent sorting to the mitochondrial intermembrane space. Mol. Cell. Biol. 12 (1992) 4677-4686
30. Kalousek F., Isaya G., and Rosenberg L.E. Rat liver mitochondrial intermediate peptidase (MIP): Purification and initial characterization. EMBO J. 11 (1992) 2803-2809
31. Kang P.J., Ostermann J., Shilling J., Neupert W., Craig E.A., and Planner N. Requirement for Hsp70 in the mitochondrial matrix for translocation and folding of precursor proteins. Nature 348 (1990) 137-142
32. Kaput J., Goltz S., and Blobel G. Nucleotide sequence of the yeast nuclear gene for cytochrome c peroxidase precursor: Functional implications of the presequence for protein transport into mitochondria. J. Biol. Chem. 257 (1982) 15054-15058
33. Kaput J., Brandriss M.C., and Prussak-Wieckowska T. In vitro import of cytochrome c peroxidase into the intermembrane space: Release of the processed form by intact mitochondria. J. Cell. Biol. 109 (1989) 101-112
34. Koll H., Guiard B., Rassow J., Ostermann J., Horwich A.L., Neupert W., and Hartl F.-U. Antifolding activity of hsp60 couples protein import into the mitochondrial matrix with export to the intermembrane space. Cell 68 (1992) 1163-1175
35. Langer T., Lu C., Echols H., Flanagan J., Hayer-Hartl M., and Hartl F.-U. Successive action of DnaK, DnaJ and GroEL along the pathway of chaperone mediated protein folding. Nature 356 (1992) 683-689
36. Lill R., Hergersberg C., Schneider H., Söllner T., Stuart R.A., and Neupert W. General and exceptional pathways of protein import into submitochondrial compartments. In: Neupert W., and Lill R. (Eds). Membrane Biogenesis and Protein Targeting (1992), Elsevier, Amsterdam
37. Lill R., Stuart R.A., Drygas M., Nargang F.E., and Neupert W. Import of cytochrome c heme lyase into mitochondria: A novel pathway into the intermembrane space. EMBO J. 11 (1992) 449-456
38. Maarse A.C., Blom J., Grivell L.A., and Meijer M. MP11, an essential gene encoding a mitochondrial membrane protein, is possibly involved in protein import into yeast mitochondria. EMBO J. 11 (1992) 3619-3628
39. Mahlke K., Pfanner N., Martin J., Horwich A.L., Hartl F.-U., and Neupert W. Sorting pathways of mitochondrial inner membrane proteins. Eur. J. Biochem. 192 (1990) 551-555
40. Manning-Krieg U.C., Scherer P.E., and Schatz G. Sequential action of mitochondrial chaperones in protein import into the matrix. EMBO J. 10 (1991) 3273-3280
41. Mayer A., Lill R., and Neupert W. Insertion and translocation of precursor proteins into isolated outer membranes of mitochondria. J. Cell. Biol. 121 (1993) 1233-1243
42. Neupert W., Hartl F.-U., Craig E.A., and Pfanner N. How do polypeptides cross the mitochondrial membranes?. Cell 63 (1990) 447-450
43. Nicholson D.W., Hergersberg C., and Neupert W. Role of cytochrome c heme lyase in the import of cytochrome c into mitochondria. J. Biol. Chem. 263 (1988) 19034-19042
44. Nobrega F.G., Nobrega M.P., and Tzagoloff A. BCSI, a novel gene required for the expression of functional Rieske iron-sulfur protein in Saccharomyces cerevisiae. EMBO J. 11 (1992) 3821-3829
45. Nunnari J., Fox T.D., and Walter P. A mitochondrial protease with two catalytic subunits of nonoverlapping specificities. Science 262 (1993) 1997-2003
46. 2 to the intermembrane space of mitochondria: kinetic analysis of intermediates demonstrates passage through the matrix. J. Biol. Chem. 270 (1995) 16932-16938
47. Ostermann J., Horwich A.L., Neupert W., and Hartl F.-U. Protein folding in mitochondria requires complex formation with hsp60 and ATP hydrolysis. Nature 341 (1989) 125-130
48. Ostermann J., Voos W., Kang P.J., Craig E.A., Neupert W., and Pfanner N. Precursor proteins in transit through mitochondrial contact sites interact with hsp70 in the matrix. FEBS Lett. 277 (1991) 281-284
49. Pfanner R., Steger H., Rassow J., Pfanner N., and Neupert W. Import pathways or precursors into mitochondria: Multiple receptor sites are followed by a common insertion site. J. Cell. Biol. 107 (1988) 2483-2490
50. Pfanner N., Rassow J., van der Klei I., and Neupert W. A dynamic model of the mitochondrial protein import machinery. Cell 68 (1992) 999-1002
51. Puziss J.W., Fikes J.D., and Bassford P.J. Analysis of mutational alterations in the hydrophilic segment of the maltose-binding protein signal peptide. J. Bacteriol. 171 (1989) 2303-2311
52. Rassow J., Hartl F.-U., Guiard B., Pfanner N., and Neupert W. Polypeptides traverse the mitochondrial envelope in an extended state. FEBS Lett. 275 (1990) 190-194
53. g-ATPase subunit 9: export from matrix requires Φ across inner membrane and matrix ATP. EMBOJ. 14 (1995) 3445-3451
54. Rospert S., Glick B.S., Jeno P., Schatz G., Todd M.T., Lorimer G.H., and Vitamen P.V. Identification and functional analysis of chaperone 10, the groES homolog from yeast mitochondria. Proc. Natl. Acad. Sci. USA 90 (1993) 10967-10971
55. Rowley N., Prip-Buus C., Westermann B., Brown C., Schwarz E., Barrell B., and Neupert W. Mdj 1p, a novel chaperone of the DnaJ family, is involved in mitochondrial biogenesis and protein folding. Cell 77 (1994) 249-259
56. 1 precursor reveals an unusually complex amino-terminal presequence. EMBO J. 3 (1984) 2137-2143
57. Scherer P.E., Manning-Krieg U.C., Jenö P., Schatz G., and Horst M. Identification of a 45-kDa protein at the import site of the yeast mitochondrial inner membrane. Proc. Natl. Acad. Sci. USA 89 (1992) 11930-11934
58. Schleyer M., and Neupert. Transport of proteins into mitochondria: Translocation intermediates spanning contact sites between outer and inner membranes. Cell 43 (1985) 339-350
59. Schneider A., Behrens M., Scherer P.E., Pratje E., Michaelis G., and Schatz G. Inner membrane protease 1, an enzyme mediating intramitochondrial sorting in yeast. EMBO J. 10 (1991) 247-254
60. Schneider H.C., Berthold J., Bauer M.F., Dietmeier K., Guiard B., Brunner M., and Neupert W. Mitochondrial Hsp70/MIM44 complex facilitates protein import. Nature 371 (1994) 768-774
61. Schulze M., and Rödel G. Accumulation of the cytochrome c oxidase subunits I and II in yeast requires a mitochondrial membrane associated protein, encoded by the nuclear SCOl gene. Mol. Gen. Genet. 216 (1989) 37-43
62. 2 into the mitochondrial intermembrane space: Specific recognition of the sorting signal. EMBO J. 10 (1993) 2295-2302
63. Segui-Real B., Kispal G., Lill R., and Neupert W. Functional independence of the protein translocation machineries in mitochondrial outer and inner membranes: Passage of preproteins through the intermembrane space. EMBO J. 12 (1993) 2211-2218
64. Steiner H., Zollner A., Haid A., Neupert W., and Lill R. Biogenesis of mitochondrial heme lyases in yeast. Import and folding in the intermembrane space. J. Biol. Chem. 270 (1995) 22842-22849
65. Stuart R.A., Neupert W., and Tropschug M. Deficiency in mRNA splicing in a cytochrome c mutant of Neurospora crassa; Importance of carboxy-terminus for import of apocytochrome c into mitochondria. EMBO J. 6 (1987) 2131-2137
66. Stuart R.A., Nicholson D.W., and Neupert W. Early steps in mitochondrial protein import: Receptor unctions can be substituted by the membrane insertion activity of apocytochrome c. Cell 60 (1989) 31-43
67. Stuart R.A., and Neupert W. Apocytochrome c: An exceptional mitochondrial precursor using an exceptional import pathway. Biochimie 72 (1990) 115-121
68. Stuart R.A., Koll H., and Neupert W. Intra-mitochondrial sorting of precursor proteins. NATO ASI Series 71 (1993) 213-223
69. Stuart R.A., Cyr D.M., Craig E.A., and Neupert W. Mitochondrial molecular chaperones: Their role in protein translocation. Trends. Biochem. Sci. 19 (1994) 87-92
70. Stuart R.A., Gruhler A., van der Klei I.J., Guiard B., Koll H., and Neupert W. The requirement of matrix ATP for the import of precursor proteins into the mitochondrial matrix and intermembrane space. Eur. J. Biochem. 220 (1994) 9-18
71. Ungermann C., Neupert W., and Cyv D.M. The role of Hsp70 in conferring unidirectionality on protein translocation into mitochondria. Science 266 (1994) 1250-1253
72. 1 subunits. Biochem. 32 (1993) 628-636
73. Van Loon A.P.G.M., Brändli A.W., and Schatz G. The presequences of two imported mitochondrial proteins contain information for intracellular and intramitochondrial sorting. Cell 44 (1986) 801-812
74. 1 presequence is a stop-transfer sequence specific for the inner membrane. EMBO J. 6 (1987) 2441-2448
75. 1 presequence. EMBO J. 8 (1987) 2433-2439
76. Voos W., Gambill B.D., Guiard B., Pfanner N., and Craig E.A. Presequence and mature part of preproteins strongly influence the dependence of mitochondrial protein import on Hsp70 in the matrix. J. Cell Biol. 123 (1993) 119-126
77. 1, and the adenine nucleotide translocator. EMBO J. 11 (1992) 4787-4794
78. 2 at 2.4A resolution. J. Mol. Biol. 212 (1990) 837-863