The effects of desflurane on splanchnic hemodynamics and oxygenation in the anesthetized pig

Anesthesia and Analgesia

Volumn 84, Issue 2, 1997, Pages 271-277

  Armbruster, Klaus ^a   Nöldge Schomburg, Gabriele F E ^a   Dressler, Irmbert M J ^a   Fittkau, Andreas J ^a   Haberstroh, Jörg ^a   Geiger, Klaus ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYBUTYRIC ACID; ACETOACETIC ACID; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; DESFLURANE; FLUNITRAZEPAM; KETAMINE; KETONE BODY; LACTIC ACID;

ANIMAL EXPERIMENT; ARTICLE; ARTIFICIAL VENTILATION; CONTROLLED STUDY; HEART OUTPUT; HEART RATE; HEART STROKE VOLUME; HEPATIC ARTERY; INHALATION ANESTHESIA; INTESTINE PERFUSION; LAPAROTOMY; LIVER METABOLISM; MEAN ARTERIAL PRESSURE; MINIMUM LUNG ALVEOLUS CONCENTRATION; NONHUMAN; OXYGEN CONSUMPTION; PORTAL VEIN BLOOD PRESSURE; PRIORITY JOURNAL; SMALL INTESTINE; SPLANCHNIC BLOOD FLOW; SUPERIOR MESENTERIC ARTERY; SWINE; TISSUE OXYGENATION;

ANESTHETICS, INHALATION; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEMODYNAMIC PROCESSES; INTESTINE, SMALL; ISOFLURANE; KETONE BODIES; LACTIC ACID; LIVER; LIVER CIRCULATION; MALE; OXYGEN; OXYGEN CONSUMPTION; SPLANCHNIC CIRCULATION; SWINE;

EID: 0342981533     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000539-199702000-00007     Document Type: Article

References (27)

1. Brown BR. Liver blood supply and regulation. In: Anesthesia in hepatic and biliary tract disease. Philadelphia: FA Davis, 1988: 17-32.
2. Gelman S. General anesthesia and hepatic circulation. Can J Physiol Pharmacol 1987;65:1762-79.
3. Nöldge GFE, Priebe HJ, Kopp KH, et al. Differences in effects of isoflurane and enflurane on splanchnic oxygenation and hepatic metabolism in the pig. Anesth Analg 1990;71:258-67.
4. Zaleski L, Abello D, Gold MI. Desflurane versus isoflurane in patients with chronic hepatic and renal disease. Anesth Analg 1993;76:353-6.
5. Merin RG, Bernard JM, Doursout MF, et al. Comparison of the effects of isoflurane and desflurane on cardiovascular dynamics and regional blood flow in the chronically instrumented dog. Anesthesiology 1991;74:568-74.
6. Kessler M, Hoeper J, Krumme BA. Monitoring of tissue perfusion and cellular function. Anesthesiology 1976;45:184-97.
7. Warltier DC, Pagel PS. Cardiovascular and respiratory actions of desflurane: is desflurane different from isoflurane? Anesth Analg 1992;75:17-31.
8. Eger EI II. New inhaled anesthetics. Anesthesiology 1994;80: 906-22.
9. Hartman JC, Pagel PS, Proctor LT, et al. Influence of desflurane, isoflurane and halothane on regional tissue perfusion in dogs. Can J Anaesth. 1992;39:877-87.
10. Nöldge GFE, Priebe HJ, Geiger K. Splanchnic hemodynamics and oxygen supply during acute normovolemic hemodilution alone and with isoflurane-induced hypotension in the anesthetized pig. Anesth Analg 1992;75:660-74.
11. Vollmar B, Conzen PF, Kerner T, et al. Blood flow and tissue oxygen pressures of liver and pancreas in rats: effects of volatile anesthetics and of hemorrhage. Anesth Analg 1992;75:421-30.
12. Nylander E, Lund N, Wranne B. Effect of increased blood oxygen affinity on skeletal muscle surface oxygen pressure fields. J Appl Physiol 1983;54:99-104.
13. Eger EI II, Johnson BH, Weiskopf RB, et al. Minimum concentration of I-653 and isoflurane in pigs: definition of a supramaximal stimulus. Anesth Analg 1988;67:1174-6.
14. Weiskopf RB, Moore MA, Eger EI II, et al. Rapid increase in desflurane concentration is associated with greater transient cardiovascular stimulation than with rapid increase in isoflurane concentration in humans. Anesthesiology 1994;80:1035-45.
15. Ebert TJ, Muzi M. Sympathetic hyperactivity during desflurane anesthesia in healthy volunteers. Anesthesiology 1993;79: 444-53.
16. Gelman SI. Disturbances in hepatic blood flow during anesthesia and surgery. Arch Surg 1976;111:881-3.
17. Bohrer SL, Rogers EL, Koehler RC, Traystam RJ. Effect of hypovolemic hypotension and laparotomy on splanchnic and hepatic arterial blood flow in dogs. Curr Surg 1981;38:325-8.
18. Saxena PR, Dhasmana KM, Prakash O. A comparison of systemic and regional hemodynamic effects of d-tubocurarine, pancuronium, and vecuronium. Anesthesiology 1983;59:102-8.
19. Weiskopf RB, Holmes MA, Eger EI II, et al. Cardiovascular effects of 1653 in swine. Anesthesiology 1988;69:303-9.
20. Weiskopf RB, Eger EI II, Noorani M, Daniel M. Fentanyl, esmolol, and clonidine blunt the transient cardiovascular stimulation induced by desflurane in humans. Anesthesiology 1994;81: 1350-5.
21. Pagel PS, Kampine JP, Schmeling WT, Warltier DC. Comparison of the systemic and coronary hemodynamic actions of desflurane, isoflurane, halothane, and enflurane in the chronically instrumented dog. Anesthesiology 1991;74:539-51.
22. Pagel PS, Kampine JP, Schmeling WT, Warltier DC. Evaluation of myocardial contractility in the chronically instrumented dog with intact autonomic nervous system function: effects of desflurane and isoflurane. Acta Anaesthesiol Scand 1993;37:203-10.
23. Lautt WW. Mechanism and role of intrinsic regulation of hepatic arterial blood flow: hepatic arterial buffer response. Am J Physiol 1985;249:G549-56.
24. 2 supply dependence. J Appl Physiol 1992;72:1499-1505.
25. Samsel RW, Cherqui D, Pietrabissa A, et al. Hepatic oxygen and lactate extraction during stagnant hypoxia. J Appl Physiol 1991; 70:186-93.
26. Nagano K, Gelman S, Parks DA, Bradley EL. Hepatic oxygen supply-uptake relationship and metabolism during anesthesia in miniature pigs. Anesthesiology 1990;72:902-10.
27. Weiskopf RB, Eger EI II, Ionescu P, et al. Desflurane does not produce hepatic or renal injury in human volunteers. Anesth Analg 1992;74:570-4.