Tissue engineering of the vascular system: From capillaries to larger blood vessels

Medical and Biological Engineering and Computing

Volumn 38, Issue 2, 2000, Pages 232-240

  Germain, L ^a   Remy Zolghadri M ^a   Auger, F ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

Blood vessel; Culture; In vitro; Organ models; Skin; Tissue engineering

Indexed keywords

BLOOD VESSELS; PHYSIOLOGY; SKIN; TISSUE CULTURE;

TISSUE ENGINEERING;

BIOMEDICAL ENGINEERING;

BIOENGINEERING; CELL CULTURE; CONFERENCE PAPER; GENE THERAPY; TISSUE REPAIR; VASCULAR SURGERY;

BLOOD VESSELS; CULTURE TECHNIQUES; GENE THERAPY; HUMANS; MODELS, BIOLOGICAL; SKIN;

EID: 0342979865     PISSN: 01400118     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02344782     Document Type: Article

References (101)

1. ABBOTT, W. M. (1997): 'Prosthetic above-knee femoral-popliteal bypass: indications and choice of graft', Semin. Vasc. Surg., 10, pp. 3-7
2. ABBOTT, W. M., GREEN, R. M., MATSUMOTO, T., WHEELER, J. R., MILLER, N., VEITH, F. J., SUGGS, W. D., HOLLIER, L., MONEY, S., and GARRETT, H. E. (1997): 'Prosthetic above-knee femoropopliteal bypass grafting: results of a multicenter randomized prospective trial. Above-knee femoropopliteal study group', J. Vasc. Surg., 25, pp. 19-28
3. ABBOTT, W. M., and VIGNATI, J. J. (1995): 'Prosthetic grafts: when are they a reasonable alternative ?', Semin. Vasc. Surg., 8, pp. 236-245
4. AUGER, F.A. (1988): 'The role of cultured autologous human epithelium in large burn wound treatment', Transplant. / Implant. Today, 5, pp. 21-26
5. AUGER, F. A., LOPEZ VALLE, C. A., GUIGNARD, R., TREMBLAY, N., NOËL, B., GOULET, F., and GERMAIN, L. (1995): 'Skin equivalent produced with human collagen', In vitro Cell. Dev. Biol. Anim., 31, pp. 432-439
6. AUGER, F. A., ROUABHIA, M., GOULET, F., BERTHOD, F., MOULIN, V., and GERMAIN, L. (1998): 'Tissue-engineering human skin substitutes developed from collagen-populated hydrated gels: clinical and fundamental applications', Med. Biol. Eng. Comput., 36, pp. 801-812
7. BELL, E., IVARSSON, B., and MERRILL, C. (1979): 'Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro', Proc. Nat. Acad. Sci., 76, pp. 1274-1278
8. BELL, E., EHRLICH, H. P., BUTTLE, D. J., and NAKATSUJI, T. (1981): 'Living tissue formed in vitro and accepted as skin-equivalent tissue of full thickness', Science, 211, pp. 1052-1054
9. BELL, E., SHER, S., HULL, B., MERRILL, C., ROSEN, S., CHAMSON, A., ASSELINEAU, D., DUBERTRET, L., COULOMB, B., LAPIERE, C., NUSGENS, B., and NEVEUX, Y. (1983): 'The reconstitution of living skin', J. Invest. Dermatol., 81, pp. 2s-10s
10. BELL, E., ROSENBERG, M., KEMP, P., GAY, R., GREEN, G. D., MUTHUKUMARAN, N., and NOLTE, C. (1991): 'Recipes for reconstituting skin', J. Biomech. Eng., 113, pp. 113-119
11. BERCELI, S. A., BOROVETZ, H. S., SHEPPECK, R. A., MOOSA, H. H., WARTY, V. S., ARMANY, M. A., HERMAN, I. M. (1991): 'Mechanisms of vein graft atherosclerosis: LDL metabolism and endothelial actin reorganization', J. Vasc. Surg., 13, pp. 336-347
12. BERGERS, G., JAVAHERIAN, K., LO, K. M., FOLKMAN, J., and HANAHAN, D. (1999): 'Effects of angiogenesis inhibitors on multistage carcinogenesis in mice', Science, 284, pp. 808-812
13. BERTHOD, F., SAHUC, F., HAYEK, D., DAMOUR, O., and COLLOMBEL, C. (1996): 'Deposition of collagen fibril bundles by long-term culture of fibroblasts in a collagen sponge', J. Biomed. Mater. Res., 32, pp. 87-93
14. BERTHOD, F., and DAMOUR, O. (1997): 'In vitro reconstructed skin models for wound coverage in deep burns', Br. J. Dermatol., 136, pp. 809-816
15. BERTHOD, F., GERMAIN, L., GUIGNARD, R., LETHIAS, C., GARRONE, R., DAMOUR, O., VAN DER REST, M., and AUGER, F. A. (1997): 'Differential expression of collagens XII and XIV in human skin and in reconstructed skin', J. Invest. Dermatol., 108, pp. 737-742
16. BICKENBACH, J. R. (1981): 'Identification and behavior of label-retaining cells in oral mucosa and skin', J. Dent. Res., 60, pp. C: 1611-1620
17. BICKENBACH, J. R., and CHISM, E. (1998): 'Selection and extended growth of murine epidermal stem cells in culture', Exp. Cell. Res., 244, pp. 184-195
18. BISCHOFF, J. (1997): 'Cell adhesion and angiogenesis', J. Clin. Invest., 99, pp. 373-376
19. BLACK, A. F., BERTHOD, F., L'HEUREUX, N., GERMAIN, L., and AUGER, F. A. (1998): 'In vitro reconstruction of capillary-like network in a tissue-engineered skin equivalent', FASEB J., 12, pp. 1331-1340
20. BORDENAVE, L., RéMY-ZOLGHADRI, M., FERNANDEZ, Ph., BAREILLE, R., and MIDY, D. (1999): 'Clinical performance of vascular grafts lined with endothelial cells', Endothelium, 6, pp. 267-275
21. BOUVARD, V., GERMAIN, L., ROMPRE, P., ROY, B., and AUGER, F. A. (1992): 'Influence of dermal equivalent maturation on the development of a cultured skin equivalent', Biochem. Cell Biol., 70, pp. 34-42
22. BOYCE, S. T., CHRISTIANSON, D. J., and HANSBROUGH, J. F. (1988): 'Structure of a collagen-GAG dermal skin substitute optimized for cultured human epidermal keratinocytes', J. Biomed. Mater. Res., 22, pp. 939-957
23. BOYCE, S. T., MICHEL, S., REICHERT, U., SHROOT, B., and SCHMIDT, R. (1990): 'Reconstructed skin from cultured human keratinocytes and fibroblasts on a collagen-glycosaminoglycan biopolymer substrate', Skin Pharmacol., 3, pp. 136-143
24. BOYCE, S. T., SUPP, A. P., HARRIGER, M. D., GREENHALGH, D. G., and WARDEN, G. D. (1995): 'Topical nutriments promote engraftment and inhibit wound contraction of cultured skin substitutes in athymic mice', J. Invest. Dermatol., 104, pp. 345-349
25. BOYCE, S. T. (1996): 'Cultured skin substitutes: a review', Tissue Eng., 2, pp. 255-266
26. BROOKS, P. C., CLARK, R. A., and CHERESH, D. A. (1994): 'Requirement of vascular integrin αvβ3 for angiogenesis', Science, 264, pp. 569-571
27. CHEN, T. R. (1977): 'In situ detection of mycoplasma contamination in cell cultures by fluorescent Hoechts 33258 stain', Exp. Cell. Res., 104, pp. 255-262
28. CINES, D. B., POLLAK, E. S., BUCK, C. A., LOSCALZO, J., ZIMMERMAN, G. A., MCEVER, R. P., POBER, J. S., WICK, T. M., KONKLE, B. A., SCHWARTZ, B. S., BARNATHAN, E. S., MCCRAE, K. R., HUG, B. A., SCHMIDT, A. M., and STERN, D. M. (1998): 'Endothelial cells in physiology and in the pathophysiology of vascular disorders', Blood, 91, pp. 3527-3561
29. CLOWES, A. W. (1997a): 'Vascular gene therapy in the 21st century', Thromb. Haemost., 78, pp. 605-610
30. CLOWES, A. W. (1997b): 'Vascular gene transfer using smooth muscle cells', Ann. N. Y. Acad. Sci., 811, pp. 293-297
31. COLVILLE-NASH, P. R., and WILLOUGHBY, D. A. (1997): 'Growth factors in angiogenesis: current interest and therapeutic potential', Mol. Med. Today, 3, pp. 14-23
32. CONTARD, P., BARTEL, R. L., JACOBS, L. 2nd, PERLISH, J. S., MACDONALD, E. D. 2nd, HANDLER, L., CONE, D., and FLEISCHMAJER, R. (1993): 'Culturing keratinocytes and fibroblasts in a three-dimensional mesh results in epidermal differentiation and formation of a basal lamina-anchoring zone', J. Invest. Dermatol., 100, pp. 35-39
33. COOPER, M. L., HANSBROUGH, J. F., SPIELVOGEL, R. L., COHEN, R., BARTEL, R. L., and NAUGHTON, G. (1991): 'In vitro optimization of a living dermal substitute employing cultured human fibroblasts on a biodegradable polyglycolic acid or polyglactin mesh', Biomaterials, 12, pp. 243-248
34. DAMOUR, O., GUEUGNIAUD, P. Y., BERTHIN-MAGHIT, P., ROUSSELLE, P., BERTHOD, F., SAHUC, F., and COLLOMBEL, C. (1994): 'A dermal substrate made of collagen-GAG-chitosan for deep bum coverage: first clinical uses', Clin. Mater., 15, pp. 273-276
35. DAMOUR, O., BRAYE, F., FOYATIER, J. L., FABREGUETTE, A., ROUSSELLE, P., VISSAC, S., and PETIT, P. (1997): 'Cultured autologous epidermis for massive burn wounds: 15 years of practice' in ROUABHIA, M. (Ed.): 'Skin substitute production by tissue engineering: clinical and fundamental applications' (Landes, Austin), pp. 23-45
36. DIAZ-FLORES, L., GUTIERREZ, R., and VARELA, H. (1994): 'Angiogenesis: an update', Histol. Histopathol., 9, pp. 807-843
37. FLEISCHMAJER, R., CONTARD, P., SCHWART, E., MACDONALD, E. D. 2nd, JACOBS, L. 2nd, and SAKAI, L. Y. (1991): 'Elastin-associated microfibrils (10 nm) in a three-dimensional fibroblast culture', 97, pp. 638-643
38. GALLICO, G. G. 3rd, O'CONNOR, N. E., COMPTON, C. C., KEHINDE, O., and GREEN, H. (1984): 'Permanent coverage of large burn wounds with autologous cultured human epithelium'. New Engl. J. Med., 331, pp. 448-451
39. GEER, J. C., MCGILL, H. C., and STRONG, J. P. (1961): 'The fine structure of human atherosclerotic lesions', Am. J. Pathol., XXXVIII, (3), pp. 263-275
40. GERMAIN, L., ROUABHIA, M., GUIGNARD, R., CARRIER, L., BOUVARD, V., and AUGER, F. A. (1993): 'Improvement of human keratinocyte isolation and culture using thermolysin', Burns, 19, pp. 99-104
41. GERMAIN, L., and AUGER, F. A. (1995): 'Tissue engineered biomaterials: biological and mechanical characteristics' in 'Encyclopedic handbook of biomaterials and bioengineering, Part B; Applications, vol. 1 (Marcel Dekker, Inc. Publishers, New York, USA), chap. 25, pp. 699-734
42. GERMAIN, L., AUGER, F. A., GRANDBOIS, E., GUIGNARD, R., GIASSON, M., BOISJOLY, H., and GUERIN, S. L. (1999): 'Reconstructed human cornea produced in vitro by tissue engineering', Pathobiology, 67, pp. 140-147
43. GHAZIZADEH, S., KOLODKA, T. M., TAICHMAN, L. B. (1998): 'The skin as a vehicle for gene therapy' in JESON, J. L. (Ed.): 'Principles of molecular medicine' (Humana Press Inc.), 82, pp. 775-779
44. GILCHREST, B. A. (1983): 'In vitro assessment of keratinocyte aging', J. Invest. Dermatol., 81, pp. 184s-189s
45. GOULET, F. GERMAIN, L., CARON, C., RANCOURT, D., NORMAND, A., and AUGER, F. A. (1997a): 'Tissue-engineered ligament' in YAHIA, L. H. (Ed.): 'Ligaments and ligamentoplasties' (Springer-Verlag, Berlin, Heidelberg), pp. 367-377
46. GOULET, F., GERMAIN, L., RANCOURT, D., CARON, C., NORMAND, A., and AUGER, F. A. (1997b): 'Tendons and ligaments' in LANZA, R., LANGER, R., and CHICK, W. L. (Eds): Textbook of tissue engineering' (Landes R. G. Co. & Academic Press. Ltd. Austin, Texas), pp. 633-644
47. GREEN, H., KEHINDE, O., and THOMAS, J. (1979): 'Growth of cultured human epidermal cells into multiple ephithelia suitable for grafting', Proc. Nat. Acad. Sci. USA, 76, pp. 5665-5668
48. GREEN, H., and BARRANDON, Y. (1988): 'Cultured epidermal cells and their use in the generation of epidermis', NIPS, 3, pp. 54-56
49. GREENHALGH, D. A., ROTHNAGEL, J. A., and ROOP, D. R. (1994): 'Epidermis: an attractive target tissue for gene therapy', J. Invest. Dermatol., 103, pp. 63S-69S
50. HANSBROUGH, J. F., BOYCE, S. T., COOPER, M. L., and FOREMAN, T. J. (1989): 'Burn wound closure with cultured autologous keratinocytes and fibroblasts attached to a collagen-glycosaminoglycan substrate', JAMA, 262, pp. 2125-2130
51. HIRAI, J., and MATSUDA, T. (1996): 'Venous reconstruction using hybrid vascular tissue composed of vascular cells and collagen: tissue regeneration process', Cell Transplant., 5, pp. 93-105
52. INGBER, D. E., and FOLKMAN, J. (1989): 'Mechanochemical switching between growth and differentiation during fibroblast growth factor-stimulated angiogenesis in vitro: role of extracellular matrix', J. Cell. Biol., 109, pp. 317-330
53. JIANG, C. K., CONNOLLY, D., and BLUMENBERG, M. (1991): 'Comparison of methods for transfection of human epidermal keratinocytes', J. Invest. Dermatol., 97, pp. 969-973
54. JONES, P. H., and WATT, F. M. (1993): 'Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression', Cell, 73, pp. 713-724
55. JONES, P. H., HARPER, S., and WATT, F. M. (1995): 'Stem cell patterning and fate in human epidermis', Cell, 80 pp. 83-93
56. KHAVARI, P. A., and KRUEGER, G. G. (1997): 'Cutaneous gene therapy', Dermatol. Clin., 15, pp. 27-35
57. KRUEGER, G. G., MORGAN, J. R., JORGENSEN, C. M., SCHMIDT, L., LI, H. L., KWAN, M. K., BOYCE, S. T., WILEY, H. S., KAPLAN, J., and PETERSEN, M. J. (1994): 'Genetically modified skin to treat disease: potential and limitations', J. Invest. Dermatol., 103, pp. 76S-84S
58. LANGER, R., and VACANTI, J. P. (1993): Tissue engineering', Science, 260, pp. 920-926
59. L'HEUREUX, N., GERMAIN, L., LABBé, R., and AUGER, F. A. (1993): 'In vitro construction of human vessel from cultured vascular cells: a morphologic study', J. Vasc.Surg., 17, pp. 499-509
60. L'HEUREUX, N., PAQUET, S., LABBé, R., GERMAIN, L., and AUGER, F. A. (1998): 'A completely biological tissue-engineered human blood vessel', FASEB J., 12, pp. 47-56
61. LOPEZ VALLE, C. A., AUGER, F. A., ROMPRE, P., BOUVARD, V., and GERMAIN, L. (1992): 'Peripheral anchorage of dermal equivalents', Br. J. Dermatol., 127, pp. 365-371
62. LU, C. Y., KHAIR-EL-DIN, T. A., DAWIDSON, I. A., BUTLER, T. M., BRASKY, K. M., VAZQUEZ, M. A., and SICHER, S. C. (1994): 'Xenotransplantation', FASEB J., 8, pp. 1122-1130
63. MARIN, J. (1995): 'Age-related changes in vascular responses: a review', Mech. Ageing Dev., 79, pp. 71-114
64. MCKEEHAN, W. L., BARNES, D., REID, L., STANBRIDGE, E., MURAKAMI, H., and SATO, G. H. (1990): 'Frontiers in mammalian cell culture', In Vitro Cell. Dev. Biol., 26, pp. 9-23
65. MICHEL, M., TOROK, N., GODBOUT, M.-J., LUSSIER, M., GAUDREAU, P., ROYAL, A., and GERMAIN, L. (1996): 'Keratin 19 as a biochemical marker of skin stem cells in vivo and in vitro', keratin 19 expressing cells are differentially localized in function of anatomic sites, and their number varies with donor age and culture stage', J. Cell Sci., 109, pp. 1017-1028
66. MICHEL, M., L'HEUREUX, N., POULIOT, R., XU, W., AUGER, F. A., and GERMAIN, L. (1999): 'Characterization of a new tissue-engineered human skin equivalent with hair', In Vitro Cell Dev. Biol. Anim., 35, pp. 318-326
67. MORGAN, J. R., BARRANDON, Y., GREEN, H., and MULLIGAN, R. C. (1987): 'Expression of an exogenous growth hormone gene by transplantable human epidermal cells', Science, 237, pp. 1476-1479
68. MORRIS, R. J., FISHER, S. M., and SLAGA, T. J. (1985): 'Evidence that the centrally and peripherally located cells in the murine epidermal proliferative unit are two distinct cell populations', J. Invest. Dermatol., 84, pp. 277-281
69. MORRIS, R. J., and POTTEN, C. S. (1994): 'Slowly cycling (label-retaining) epidermal cells behave like clonogenic stem cells in vitro'. Cell Prolif., 27, pp. 279-289
70. MORRIS, R. J., and POTTEN, C. S. (1999): 'Highly persistent label-retaining cells in the hair follicules of mice and their fate following induction of anagen', J. Invest Dermatol., 112, pp. 470-475
71. MOULIN, V., AUGER, F. A., O'CONNOR-MCCOURT, M., and GERMAIN, L. (1997): 'Fetal and postnatal sera differentially modulate human dermal fibroblast phenotypic and functional features in vitro', J. Cell. Physiol., 171, pp. 1-10
72. NIKLASON, L. E., GAO, J., ABBOTT, W. M., HIRSCHI, K. K., HOUSER, S., MARINI, R., and LANGER, R. (1999): 'Functional arteries grown in vitro', Science, 284, pp. 498-493
73. OBERPENNING, F., MENG, J., YOO, J. J., and ATALA, A. (1999): 'De novo reconstitution of a functional mammalian urinary bladder by tissue engineering', Nat. Biotechnol., 17, pp. 149-155
74. O'CONNOR, N. E., MULLIKEN, J. B., BANKS-SCHLEGEL, S., KEHINDE, O., and GREEN, H. (1981): 'Grafting of burns with cultured epithelium prepared from autologous epidermal cells', Lancet, 1, pp. 75-78
75. OWENS, G. K. (1995): 'Regulation of differentiation of vascular smooth muscle cells', Physiol. Rev., 75, pp. 487-517
76. PAQUETTE, J. S., GOULET, F., BOULET, L. P., LAVIOLETTE, M., TREMBLAY, N., CHAKIR, J., GERMAIN, L., and AUGER, F. A. (1998): 'Three-dimensional production of bronchi in vitro', Can. Respir. J., 5, p. 43
77. PICKERING, J. G., JEKANOWSKI, J., WEIR, L., TAKESHITA, S., LOSORDO, D. W., and ISNER, J. M. (1994): 'Liposome-mediated gene transfer into human vascular smooth muscle cells', Circulation, 89, pp. 13-21
78. PRUNIéRAS, M., RéGNIER, M., and WOODLEY, D. (1983): 'Methods for cultivation of keratinocytes with air-liquid interface', J. Invest. Dermatol., 81, pp. 28s-33s
79. RéMY, M., BAREILLE, R., VILLARS, F., ROUAIS, F., GORODKOV, A. J., and BORDENAVE, L. (1998): 'Endothelial cells lining a polyester fabrics express a procoagulant phenotype in vitro', Med. Biol. Eng. Comput., 36, pp. 256-257
80. RéMY, M., VALLI, N., BRETHES, D., MONTIS, K., DOBROVA, N. B., NOVIKOVA, S. P., GORODKOV, A. J., and BORDENAVE, L. (1999): 'In vitro and in situ Intercellular Adhesion Molecule-1 (ICAM-1) expression by endothelial cells lining a polyester fabric', Biomaterials, 20 pp. 241-251
81. RHEINWALD, J. G., and GREEN, H. (1975): 'Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells', Cell, 6, pp. 331-344
82. RHEINWALD, J. G., and GREEN, H. (1977): 'Epidermal growth factor and the multiplication of cultured human epidermal keratinocytes', Nature, 265, pp. 421-424
83. RISAU, W. (1997): 'Mechanisms of angiogenesis', Nature, 386, pp. 671-674
84. SAHUC, F., NAKAZAWA, K., BERTHOD, F., DAMOUR, O., and COLLOMBEL, C. (1996): 'Mesenchymal-epithelial interactions regulate gene expression of type VII collagen and kalinin in keratinocytes and dermal-epidermal junction formation in a skin equivalent model', Wound Repair Regen., 4, pp. 93-102
85. SAYERS, R. D., RAPTIS, S., BERCE, M., and MILLER, J. H. (1998): 'Long-term results of femorotibial bypass with vein or polytetrafluoroethylene', Br. J. Surg., 85, pp. 934-938
86. SEPP, N., FRITSCH, P., and LUGER, T. A. (1997): 'Endothelial cells and angiogenesis', Exp. Dermatol., 6, pp. 272-273
87. SLIVKA, S. R., LANDEEN, L., DONNELLY, T., ZIMBER, M., NAUGHTON, G. K., and BARTEL, R. L. (1991): 'Characterization of a three dimensional co-culture of neonatal human fibroblast and keratinocytes', J. Invest. Dermatol., 96, p. 544
88. STOCLET, J. C., andRIANTSITOHAINA, R., L'HEUREUX, N., MARTINEZ, C., GERMAIN, L., and AUGER, F. A. (1996): 'Use of human vessels and human smooth muscle cells in pharmacology', Cell Biol. Toxicol., 12, pp. 223-225
89. TAN, O. T., and STAFFORD, T. J. (1971): 'Cutaneous circulation' in FITZPATRICK, T. B., EISEN, A. Z., WOLFF, K., FREEDBERG, I. M., and AUSTEN, K. F. (Eds.): 'Dermatology in general medicine, 3rd edn' (McGraw-Hill, Inc.), pp. 357-366
90. TEUMER, J., LINDAHL, A., and GREEN, H. (1990): 'Human growth hormone in the blood of athymic mice grafted with cultures of hormone-secreting human keratinocytes', FASEB J., 4, pp. 3245-3250
91. THYBERG, J., HEDIN, U., SJOLUND, M., PALMBERG, L., and BOTTGER, B. A. (1990): 'Regulation of differentiated properties and proliferation of arterial smooth muscle cells', Arteriosclerosis, 10, pp. 966-990
92. TRUEB, J., and TRUEB, B. (1992): 'Type XIV collagen is a variant of undulin', Eur. J. Biochem., 207, pp. 549-557
93. VEELKEN, H., JESUITER, H., MACKENSEN, A., KULMBURG, P., SCHULTZE, J., ROSENTHAL, F., MERTELSMANN, R., and LINDEMANN, A. (1994): 'Primary fibroblasts from human adults as target cells for ex vivo transfection and gene therapy'. Hum. Gene Ther., 5, pp. 1203-1210
94. VEITH, F. J., GUPTA, S. K., ASCER, E., WHITE-FLORES, S., SAMSON, R. H., SCHER, L. A., TOWNE, J. B., BERNHARD, V. M., BONIER, P., FLINN, W. R., ASTELFORD, P., YAO, J. S. T., and BERGAN, J. J. (1986): 'Six year prospective multicenter randomized comparison of autologous saphenous vein and expanded polytetrafluoroethylene grafts in infrainguinal arterial reconstructions', J. Vasc. Surg., 3, pp. 104-114
95. VERNON, R. B., and SAGE, E. H. (1995): 'Between molecules and morphology. Extracellular matrix and creation of vascular form', Am. J. Pathol., 147, pp. 873-883
96. VILLASCHI, S., and NICOSIA, R. F. (1994): 'Paracrine interactions between fibroblasts and endothelial cells in a serum-free coculture model: modulation of angiogenesis and collagen gel contraction', Lab. Invest.,71 pp. 291-299
97. WEINBERG, C. B., and BELL, E. (1986): 'A blood vessel model constructed from collagen and cultured vascular cells', Science, 231, pp. 397-400
98. WHALEN, E., DONNELLY, T. A., NAUGHTON, G., and RHEINS, L. A. (1994): 'The development of three-dimensional in vitro human tissue models', Hum. Exp. Toxicol., 13, pp. 853-859
99. XU, X. M, OHASHI, K., SANDUJA, S. K., RUAN, K. H., WANG, L. H., and WU, K. K. (1993): 'Enhanced prostacyclin synthesis in endothelial cells by retovirus-mediated transfer of prostaglandin H synthase cDNA', J. Clin. Invest., 91, pp. 1843-1849
100. YOUNG, D. M., and MATHES, S. J. (1994): 'Skin and subcutaneous tissue' in 'Principles of surgery, 6th edn', Schwartz Shires Spencer, (McGraw-Hill), pp. 515-530
101. YOUNG, D. M., GREULICH, K. M., and WEIER, H. G. (1996): 'Species-specific in situ hybridization with fluorochrome-labeled DNA probes to study vascularization of human skin grafts on athymic mice', J. Burn Care Rehabil., 17, pp. 305-310