Pharmacokinetics of ethinyloestradiol in rabbits after intravenous administration

Contraception

Volumn 53, Issue 5, 1996, Pages 307-312

  Fernández, Nelida ^a   Sierra, M ^a   Diez, M J ^a   Teran T ^a   Sahagun A M ^a   Garcia J J ^a  

^a UNIVERSITY OF LEÓN   (Spain)

Author keywords

ethinyloestradiol; intravenous administration; oestrogens; pharmacokinetics; rabbits

Indexed keywords

ETHINYLESTRADIOL;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; COMPARTMENT MODEL; DOSE RESPONSE; DRUG ABSORPTION; DRUG DISTRIBUTION; ESTRADIOL BLOOD LEVEL; FEMALE; HORMONAL CONTRACEPTION; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; ORAL CONTRACEPTION; RABBIT;

EID: 0342961067     PISSN: 00107824     EISSN: None     Source Type: Journal    
DOI: 10.1016/0010-7824(96)00065-0     Document Type: Article

References (18)

1. Masterson BJ. Oral contraceptive agents: current status. Am J Surg 1988;155:619-27.
2. Godsland IF, Cook D, Wynn V. Clinical and metabolic considerations of long-term oral contraceptive use. Am J Obstet Gynecol 1992;166:1955-63.
3. Goldzieher JW. Pharmacokinetics and metabolism of ethinyl estrogens. In: Goldzieher JW, Fotherby K, eds. Pharmacology of the contraceptive steroids. New York:Raven Press, 1994:127-51.
4. Hümpel M, Nieuweboer B, Wendt H, Speck U. Investigations of pharmacokinetics of ethinyloestradiol to specific consideration of a possible first-pass effect in women. Contraception 1979;19:421-32.
5. Kuhnz W, Louton T, Back DJ, Michaelis K. Radioimmunological analysis of ethinylestradiol in human serum. Arzneim-Forsch Drug Res 1993;43:16-21.
6. Dibbelt L, Knuppen R,. Jutting G, Heimann S, Klipping CO, Parikka-Olexih H. Group comparison of serum ethinylestradiol, SHBG and CBG levels in 83 women using two low-dose combination oral contraceptives for three months. Contraception 1991;43:1-21.
7. Fernández N, García JJ, Diez MJ, Terán MT, Sierra M. Rapid high-performance liquid chromatographic assay of ethynyloestradiol in rabbit plasma. J Chromatogr Biomed Appl 1993;619:143-7.
8. Metzler CM, Weiner DL. PCNONLIN user's guide, version 3.0. Statistical Consultants, Lexington, KY, 1989.
9. Dunne A. JANA: A new iterative polyexponential curve stripping program. Comput Meth Prog Biomed 1985;20: 269-75.
10. Yamaoka K, Nakagawa T, Uno T. Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations. J Pharmacokinet Biopharm 1978;6:165-75.
11. Gibaldi M, Perrier D. Multicompartment models. In: Pharmacokinetics. New York:Marcel Dekker, 1982:45-111.
12. Yamaoka K, Nakagawa T, Uno T. Statistical moments in pharmacokinetics. J Pharmacokinet Biopharm 1978;6:547-58.
13. Fotherby K, Akpoviroro J, Abdel-Rahman, HA et al. Pharmacokinetics of ethinyloestradiol in women fron different populations. Contraception 1981;23:487-97.
14. Back DJ, Breckeridge AM, Cross KJ, Orme ML'E, Thomas E. An antibiotic interaction with ethinyloestradiol in the rat and rabbit. J Steroid Biochem 1982;16:407-13.
15. Düsterberg B, Kühne G, Tüuber U. Half-lives in plasma and bioavailability of ethinylestradiol in laboratory animals. Arzneim-Forsch Drug Res 1986;36:1187-90.
16. Back DJ, Breckeridge AM, Crawford FE et al. An investigation of the pharmacokinetics of ethinylestradiol in women using radioimmunoassay. Contraception 1979; 20:263-73.
17. Orme ML'E, Back DJ. Factors affecting the enterohepatic circulation of oral contraceptive steroids. Am J Obstet Gynecol 1990;163:2146-52.
18. Zacur HA, Burkman RT, Kimball AW, Kwiterovich P, Bell WR. Existence of multiple peaks in plasma ethinyl estradiol and norethindrone after oral administration of a contraceptive pill. J Clin Endocrinol Metab 1992;75: 1268-72.