메뉴 건너뛰기




Volumn 76, Issue 2, 1998, Pages 107-116

Liquid homogenization studies in animal cell bioreactors of up to 8 m3 in volume

Author keywords

Aeration; Agitation; Animal cell bioreactors; Homogenization; Largescale

Indexed keywords


EID: 0342944965     PISSN: 09603085     EISSN: None     Source Type: Journal    
DOI: 10.1205/096030898531873     Document Type: Article
Times cited : (17)

References (34)
  • 1
    • 0024748281 scopus 로고
    • The effects of agitation intensity with and without continuous sparging on the growth and antibody production of hybridoma cells
    • Oh, S. K.W., Nienow, A. W., Emery, A. N. and Al-Rubeai, M., 1989, The effects of agitation intensity with and without continuous sparging on the growth and antibody production of hybridoma cells, J Biotechn, 12: 45-62.
    • (1989) J Biotechn , vol.12 , pp. 45-62
    • Oh, S.K.W.1    Nienow, A.W.2    Emery, A.N.3    Al-Rubeai, M.4
  • 2
    • 0009947458 scopus 로고
    • The impact of fluid dynamics on the biological performance of free suspension culture - Further studies
    • Kioukia, N., Nienow, A. W., Al-Rubeai, M. and Emery, A. N., 1992, The impact of fluid dynamics on the biological performance of free suspension culture - Further studies, TransIChemE, 70(C); 143-148.
    • (1992) TransIChemE , vol.70 , Issue.C , pp. 143-148
    • Kioukia, N.1    Nienow, A.W.2    Al-Rubeai, M.3    Emery, A.N.4
  • 3
    • 0027626501 scopus 로고
    • Production of tPA in recombinant CHO cells under oxygen-limited conditions
    • Lin, A. A., Kimura, R. and Miller, W. M., 1993, Production of tPA in recombinant CHO cells under oxygen-limited conditions, Biotechnol Bioeng, 42: 339-350.
    • (1993) Biotechnol Bioeng , vol.42 , pp. 339-350
    • Lin, A.A.1    Kimura, R.2    Miller, W.M.3
  • 4
    • 0343504975 scopus 로고
    • An overview of animal cell biotechnology: The conjoint application of art, science and engineering
    • Butterworth-Heinemann, New York
    • Spier, R. E., 1991, An overview of animal cell biotechnology: The conjoint application of art, science and engineering, in Animal Cell Bioreactors (Butterworth-Heinemann, New York).
    • (1991) Animal Cell Bioreactors
    • Spier, R.E.1
  • 7
    • 0013141276 scopus 로고    scopus 로고
    • Mixing of liquids in stirred tanks
    • Harnby, N., Edwards, M. F. and Nienow, A. W. (eds) (Butterworth-Heinemann, Oxford)
    • Edwards, M. F., Baker, M. and Godfrey, J. C., 1997, Mixing of liquids in stirred tanks, in Mixing in the Process Industries, (2nd ed) Harnby, N., Edwards, M. F. and Nienow, A. W. (eds) (Butterworth-Heinemann, Oxford) pp. 137-158.
    • (1997) Mixing in the Process Industries, (2nd Ed) , pp. 137-158
    • Edwards, M.F.1    Baker, M.2    Godfrey, J.C.3
  • 14
    • 0016967073 scopus 로고
    • Mixing of viscoelastic fluids with helical-ribbon agitators - Mixing time and flow patterns
    • Carreau, P. J., Patterson, I. and Yap, C. Y., 1976, Mixing of viscoelastic fluids with helical-ribbon agitators - Mixing time and flow patterns, Canad J Chem Eng, 56: 135-142.
    • (1976) Canad J Chem Eng , vol.56 , pp. 135-142
    • Carreau, P.J.1    Patterson, I.2    Yap, C.Y.3
  • 15
    • 0028397039 scopus 로고
    • An experimental study of mixing in a proto-fermentor agitated by dual Rushton turbines
    • Cronin, D. G., Nienow, A. W. and Moody, G. W., 1994, An experimental study of mixing in a proto-fermentor agitated by dual Rushton turbines. Food Bioprod Proc, 72: 35-40.
    • (1994) Food Bioprod Proc , vol.72 , pp. 35-40
    • Cronin, D.G.1    Nienow, A.W.2    Moody, G.W.3
  • 16
    • 0002470128 scopus 로고
    • Mixing and mass transfer in filamentous fermentations
    • King, R. (ed) (Elsevier Applied Science Publishers)
    • Cooke, M., Middleton, J. C. and Bush, J., 1988, Mixing and mass transfer in filamentous fermentations, Proc 2nd Intern Conf on Bioreactor Fluid Dynamics, King, R. (ed) (Elsevier Applied Science Publishers) pp. 37-64.
    • (1988) Proc 2nd Intern Conf on Bioreactor Fluid Dynamics , pp. 37-64
    • Cooke, M.1    Middleton, J.C.2    Bush, J.3
  • 17
    • 0031214667 scopus 로고    scopus 로고
    • On impeller circulation and mixing effectiveness in the turbulent flow regime
    • Nienow, A. W., 1997, On impeller circulation and mixing effectiveness in the turbulent flow regime, Chem Eng Sci, 52: 2557-2565.
    • (1997) Chem Eng Sci , vol.52 , pp. 2557-2565
    • Nienow, A.W.1
  • 18
    • 0002908063 scopus 로고    scopus 로고
    • Gas-liquid dispersion and mixing
    • Harnby, N., Edwards, M. F. and Nienow, A. W. (eds) (Butterworth-Heinemann, Oxford)
    • Middleton, J. C., 1997, Gas-liquid dispersion and mixing, in Mixing in the Process Industries (2nd ed) Harnby, N., Edwards, M. F. and Nienow, A. W. (eds) (Butterworth-Heinemann, Oxford) pp. 322-363.
    • (1997) Mixing in the Process Industries (2nd Ed) , pp. 322-363
    • Middleton, J.C.1
  • 19
    • 0023162924 scopus 로고
    • The dependency on scale of power numbers of Rushton disc turbines
    • Bujalski, W., Nienow, A. W., Chatwin, S. and Cooke, M., 1987, The dependency on scale of power numbers of Rushton disc turbines, Chem Eng Sci, 41: 317-326.
    • (1987) Chem Eng Sci , vol.41 , pp. 317-326
    • Bujalski, W.1    Nienow, A.W.2    Chatwin, S.3    Cooke, M.4
  • 20
    • 0001257504 scopus 로고
    • A rational method for measuring blending performance, and comparison of different impeller types
    • Ruszkowski, S., 1994, A rational method for measuring blending performance, and comparison of different impeller types, Proc 8th Europ Conf on Mixing, IChemE Symp Ser, 136: 283-292.
    • (1994) Proc 8th Europ Conf on Mixing, IChemE Symp Ser , vol.136 , pp. 283-292
    • Ruszkowski, S.1
  • 22
    • 0025478286 scopus 로고
    • Agitators for mycelial fermentations
    • Nienow, A. W., 1990, Agitators for mycelial fermentations, Trends in Biotech, 8: 224-233.
    • (1990) Trends in Biotech , vol.8 , pp. 224-233
    • Nienow, A.W.1
  • 23
    • 84984288486 scopus 로고
    • Ein neuer, axial fördernder Rührer zum Dispergieren von Gas in Flüssigkeiten
    • Hass, V. C. and Nienow, A. W., 1989, Ein neuer, axial fördernder Rührer zum Dispergieren von Gas in Flüssigkeiten, Chem Ing Techn, 61: 152-154.
    • (1989) Chem ing Techn , vol.61 , pp. 152-154
    • Hass, V.C.1    Nienow, A.W.2
  • 24
    • 0026878546 scopus 로고
    • Power, gas dispersion and homogenisation characteristics of Scaba SRGT and Rushton turbine impellers
    • Saito, F., Nienow, A. W., Chatwin, S. and Moore, I. P. T., 1992, Power, gas dispersion and homogenisation characteristics of Scaba SRGT and Rushton turbine impellers, J Chem Eng Japan, 25: 281-287.
    • (1992) J Chem Eng Japan , vol.25 , pp. 281-287
    • Saito, F.1    Nienow, A.W.2    Chatwin, S.3    Moore, I.P.T.4
  • 25
    • 0001890831 scopus 로고    scopus 로고
    • Suspension of solids in liquids
    • Harnby, N., Edwards, M. F. and Nienow, A. W. (eds) (Butterworth-Heinemann, Oxford)
    • Nienow, A. W., 1997, Suspension of solids in liquids, in Mixing in the Process Industries, Harnby, N., Edwards, M. F. and Nienow, A. W. (eds) (Butterworth-Heinemann, Oxford) pp 364-383.
    • (1997) Mixing in the Process Industries , pp. 364-383
    • Nienow, A.W.1
  • 27
    • 0019392897 scopus 로고
    • Energy dissipation rate distribution in mixing vessels and its effects on liquid-liquid dispersion and solid-liquid mass transfer
    • Okamoto, Y., Hishikawa, M. and Hashimoto, K., 1981, Energy dissipation rate distribution in mixing vessels and its effects on liquid-liquid dispersion and solid-liquid mass transfer, Intern Chem Eng, 21: 88-94.
    • (1981) Intern Chem Eng , vol.21 , pp. 88-94
    • Okamoto, Y.1    Hishikawa, M.2    Hashimoto, K.3
  • 28
    • 0026124852 scopus 로고
    • Microscopic visualisation of insect cell-bubble interactions
    • Chalmers. J. J. and Bavarian, F., 1991, Microscopic visualisation of insect cell-bubble interactions, Biotechnol Prog, 7: 140-150.
    • (1991) Biotechnol Prog , vol.7 , pp. 140-150
    • Chalmers, J.J.1    Bavarian, F.2
  • 29
    • 0347552384 scopus 로고
    • Rückvermischung in Blasensäulen mit Einbauten
    • Berg, S. and Schlüter, S., 1995, Rückvermischung in Blasensäulen mit Einbauten, Chem Ing Techn, 67: 289-299.
    • (1995) Chem ing Techn , vol.67 , pp. 289-299
    • Berg, S.1    Schlüter, S.2
  • 30
    • 0023399120 scopus 로고
    • Oxygen transfer in animal cell culture media
    • Lavery, M. and Nienow, A. W., 1987, Oxygen transfer in animal cell culture media, Biotechnol Bioeng, 30: 368-373.
    • (1987) Biotechnol Bioeng , vol.30 , pp. 368-373
    • Lavery, M.1    Nienow, A.W.2
  • 31
    • 0027155318 scopus 로고
    • Oxygenation of cell cultures
    • Henzler, H.-J. and Kauling, D. J., 1993, Oxygenation of cell cultures, Bioproc Eng, 9: 61-75.
    • (1993) Bioproc Eng , vol.9 , pp. 61-75
    • Henzler, H.-J.1    Kauling, D.J.2
  • 32
    • 0026569715 scopus 로고
    • Further studies of the culture of mouse hybridomas in an agitated bioreactor with and without continuous sparging
    • Oh, S. K. W., Nienow, A. W., Emery, A. N. and Al-Rubeai, M., 1992, Further studies of the culture of mouse hybridomas in an agitated bioreactor with and without continuous sparging, J Biotechnol 22: 245-270.
    • (1992) J Biotechnol , vol.22 , pp. 245-270
    • Oh, S.K.W.1    Nienow, A.W.2    Emery, A.N.3    Al-Rubeai, M.4
  • 33
    • 85030057040 scopus 로고
    • Mixing and mass transfer in a stirred bioreactor under animal cell operating conditions
    • The University of Birmingham, UK
    • Chan, R., 1995, Mixing and mass transfer in a stirred bioreactor under animal cell operating conditions, MSc-Project (The University of Birmingham, UK).
    • (1995) MSc-Project
    • Chan, R.1
  • 34
    • 85030039367 scopus 로고
    • Untersuchungen mit Mehrkanal-Mikrosonden zum Einfluß suspendierter Feststoffe auf die Hydrodynamik in Blasensäulen-Reaktoren für Chemie und Biotechnologie
    • Wolff, C., 1989, Untersuchungen mit Mehrkanal-Mikrosonden zum Einfluß suspendierter Feststoffe auf die Hydrodynamik in Blasensäulen-Reaktoren für Chemie und Biotechnologie. VDI-Fortschrittsber, 3: 176.
    • (1989) VDI-Fortschrittsber , vol.3 , pp. 176
    • Wolff, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.