Physiological roles and properties of potassium channels in corporal smooth muscle

Drugs of Today

Volumn 36, Issue 2-3, 2000, Pages 147-154

  Lee, Sung Won ^a,b,c  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b Sungkyunkwan University School of Medicine   (South Korea)

^c Sungkyunkwan University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM CHANNEL; CALCIUM ION; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC GMP DEPENDENT PROTEIN KINASE; POTASSIUM CHANNEL; POTASSIUM ION; PROSTAGLANDIN E1; PROTEIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; CORPUS CAVERNOSUM; ERECTILE DYSFUNCTION; GENE THERAPY; IMPOTENCE; MEMBRANE POTENTIAL; NONHUMAN; PENIS ERECTION; PHYSIOLOGY; RAT; SMOOTH MUSCLE; SMOOTH MUSCLE FIBER MEMBRANE; SMOOTH MUSCLE RELAXATION; VASCULAR RESISTANCE;

EID: 0342859348     PISSN: 16993993     EISSN: 16994019     Source Type: Journal    
DOI: 10.1358/dot.2000.36.2-3.568788     Document Type: Conference Paper

References (42)

1. Lerner, S.E., Melman, A., Christ, G.J. A review of erectile dysfunction: New insights and more questions. J Urol 1993, 149: 1246-55.
2. Christ, G.J. The penis as a vascular organ: The importance of corporal smooth muscle tone in the control of erection. Urol Clin North Am 1995, 22: 727-45.
3. Saenz De Tejada, I., Goldstein, I., Azadzoi, K., Krane, R.J., Cohen, R.A. Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence. N Engl J Med 1989, 320: 1020-30.
4. Campos de Carvalho, A.C., Moreno, A.P., Christ, G.J. et al. Gap junctions formed of connexin 43 interconnect smooth muscle cells of the human corpus cavernosum. J Urol 1993, 149: 1568-75.
5. Cho, C.K., Suh, J.K., Chang, T.G. et al. Effect of calcium channel blockers on penile erection in vivo. J Urol 1994, 151: 321A.
6. Christ, G.J., Moreno, A., Parker, M.E. et al. Intercellular communication through gap junctions: A potential role in pharmacomechanical coupling and syncytial tissue contraction in vascular smooth muscle isolated from the human corpus cavernosum. Life Sci 1991, 49: PL95-200.
7. 2+ in cultured human corporal smooth muscle cells. Am J Physiol 1992, 263: C373-83.
8. Christ, G.J., Spray, D.C., Brink, P.R. Characterization of K currents in cultured human corporal smooth muscle cells. J Androl 1993, 14: 319-28.
9. Christ, G.J., Brink, P.R., Melman, A. et al. The role of gap junctions and ion channels in the modulation of electrical signals in human corpus cavernosum smooth muscle. Int J Impot Res 1993, 5: 77-96.
10. Moreno, A.P., Campos de Carvalho, A.C., Christ, G.J. et al. Gap junctions between human corpus cavernosum smooth muscle cells: Gating properties and unitary conductance. Am J Physiol 1993, 264: C80-92.
11. Andersson, K.E. Clinical pharmacology of potassium channel openers. Pharmacol Toxicol 1992, 70: 244-54.
12. Brayden, J.E., Nelson, M.T. Regulation of arterial tone by activation of calcium dependent potassium channels. Science 1992, 256: 532-5.
13. 1-adrenergic agonist efficacy in isolated rat aorta. J Pharmacol Exp Ther 1993, 266: 1054-65.
14. Ishikawa, T., Hume, J.R., Keef, K.D. Regulation of Ca2+ channels by cAMP and cGMP in vascular smooth muscle. Circ Res 1993, 73: 1128-37.
15. + channels in cultured vascular smooth muscle cells. Circ Res 1994, 74: 471-6.
16. Longman, S.D., Hamilton, T.C. Potassium channels activator drugs: Mechanism of actions, pharmacological properties, and therapeutic potential. Med Res Rev 1992, 12: 73-148.
17. Ca) channel in cultured human corporal smooth muscle cells. J Urol 1995, 153: 818-25.
18. Toro, L., Vaca, L., Stefani, E. Calcium-activated potassium channels from coronary smooth muscle reconstituted in lipid bilayers. Am J Physiol 1991, 260: H1779-89.
19. 2+ activated potassium channels and ATPsensitive potassium channels as modulators of vascular tone. Trends Cardiovasc Med 1993, 3: 54-60.
20. Atkinson, N.S., Robertson, G.A., Ganetzky, B. A component of calcium-activated potassium channels encoded by the Drosophila slo locus. Science 1991, 253: 551-5.
21. Adelman, J.P., Shen, K.Z., Kavanaugh, M.P. et al. Calcium-activated potassium channels expressed from cloned complementary DNAs. Neuron 1992, 9: 209-16.
22. Butler, A., Tsunoda, S., McCobb, D.P., Wei, A., Salkoff, L. mSlo, a complex mouse gene encoding "maxi" calcium-activated potassium channels. Science 1993, 261: 221-4.
23. McCobb, D.P., Fowler, N.L., Featherstone, T. et al. A human calcium-activated potassium channel gene expressed in vascular smooth muscle. Am J Physiol 1995, 269: H767-77.
24. 2+ dependent K channels classified by the application of tetraethylammonium distribute to smooth muscle membranes of the rabbit portal vein. Pflügers Arch 1985, 405: 173-9.
25. ca channel in cultured human corporal smooth muscle cells. Int J Impot Res 1999, 11: 189-99.
26. Kume, H., Graziano, M.P., Kotlikoff, M.I. Stimulatory and inhibitory regulation of calcium-activated potassium channels by guanine nucleotide-binding proteins. Proc Natl Acad Sci USA 1992, 89: 11051-5.
27. Sadoshima, J.I., Akaike, N., Kanaide, H., Nakamura, M. Cyclic AMP modulates Ca-activated K channel in cultured smooth muscle cells of rat aortas. Am J Physiol 1988, 255: H754-9.
28. Ca channels by Gs alpha independent of phosphorylation by protein kinase A. Am J Physiol 1993, 265: H1460-5.
29. Robertson, B.E., Schubert, R., Hescheler, J., Nelson, M.T. cGMP-dependent protein kinase activates Ca-activated K channels in cerebral artery smooth muscle cells. Am J Physiol 1993, 265: C299-303.
30. + channels are stimulated by cyclic guanosine monophosphate-dependent protein kinase in canine coronary artery smooth muscle cells. Pflügers Arch 1993, 463: 167-72.
31. Bolotina, V.M., Najibi, S., Palacino, J.J., Pagano, P.J., Cohen, R.A. Nitric oxide directly activates potassium channels in vascular smooth muscle. Nature 1994, 368: 850-3.
32. 2+-activated K channel (hSlo) cDNAs: Evidence for high levels of expression in pancreatic islets and identification of a flanking genetic marker. Diabetologia 1996, 39: 891-8
33. + channels in cardiac muscle. Nature 1983, 305: 147-8.
34. Ashcroft, S.J.H., Ashcroft, F.M. Properties and functions of ATP-sensitive K channels. Cell Signal 1990, 2: 197-214.
35. 2+-activated potassium channels and ATP-sensitive potassium channels as modulators of vascular tone. Trends Cardiovasc Med 1993, 3: 54-60.
36. Nelson, M.T., Huang, Y., Brayden, J.E., Hescheler, J., Standen, N.B. Activation of K channels is involved in arterial dilations to calcitonin gene-related peptide. Nature 1990, 344: 770-3.
37. Nelson, M.T., Patlak, J.B., Worley, J.F., Standen, N.B. Calcium channels, potassium channels and voltage dependence of arterial smooth muscle cell tone. Am J Physiol 1990, 259: C3-18.
38. Standen, N.B., Quayle, J.M., Davies, N.W., Brayden, J.E., Huang, Y., Nelson, M.T. Hyperpolarizing vasodilators activate ATP-sensitive K channels in arterial smooth muscle. Science 1989, 245: 177-80.
39. ATP channel. Nature 1994, 370: 456-9.
40. Lee, S.W., Wang, H-Z., Christ, G.J. Characterization of ATP-sensitive potassium channels in human corporal smooth muscle cells. Int J Impot Res 1999, 11: 179-88.
41. Zhang, H.L., Bolton, T.B. Two types of ATP-sensitive potassium channels in rat portal vein smooth muscle cells. Br J Pharmacol 1996, 118: 105-14.
42. Christ, G.J., Rehman, J., Day, N., Salkoff, L., Melman, A., Geliebter, J. Transfection of rat corporal tissue in vivo with the hSlo cDNA is associated with physiologically relevant alterations in erectile function. Am J Physiol 1999, in press.