Development of a radioimmunoassay for the novel N-type calcium channel blocker, SNX-111 (CI-1009)

Journal of Clinical Ligand Assay

Volumn 19, Issue 4, 1996, Pages 229-233

  Barksdale, Charles M ^a   Tarczy Hornoch, Katalin ^b   Nordblom, Gerald D ^a   Kristipati, Ramasharma ^b   Miljanich, George P ^b   Kugler, Alan R ^a  

^a PFIZER INC   (United States)

^b Neurex Corporation   (United States)

Author keywords

CI 1009; N type neuronal voltage sensitive calcium channel blocker; Neuroprotectant; Radioimmunoassay; SNX 111

Indexed keywords

CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; OMEGA CONOTOXIN MVIIA; PD 146651; UNCLASSIFIED DRUG;

ARTICLE; BLOOD BRAIN BARRIER; BRAIN ISCHEMIA; DRUG DETERMINATION; DRUG STRUCTURE; NEUROPROTECTION; RADIOIMMUNOASSAY; STRUCTURE ANALYSIS;

BOVINAE; GASTROPODA; ORYCTOLAGUS CUNICULUS;

EID: 0342827329     PISSN: 10811672     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. Olivera BM, Gray WR, Zeikus R, et al: Peptide neurotoxins from fishhunting cone snails. Science 1985;230:1338.
2. Olivera BM, Cruz LJ, de Santos V, et al: Neural calcium channel antagonists. Discrimination between calcium channel subtypes using ω-Conotoxin from Conus magus venom. Biochem 1987;26:2086.
3. Hille B: Ionic channels of excitable membranes. Sunderland, Massachusetts, Sinauer Associates, 1984, pp 76-98.
4. Barinaga M: Finding new drugs to treat stroke. Science 1996;272:664-666.
5. Brennan MB: Stroke drugs send researchers back to the drawing board. Chemical and Engineering News 1996;74:41-45.
6. Barksdale CM, Rossi DT, Nordblom GD, et al: Metabolic studies of plasma from patients dosed with SNX-111 (CI-1009), an N-type calcium channel blocker, Abstract PI-970, 10th International Congress of Endocrinology, San Francisco, June 1996.