Influence of neutron activation factors on matrix tablets for site specific delivery to the colon

European Journal of Pharmaceutical Sciences

Volumn 10, Issue 3, 2000, Pages 225-235

  Ahrabi, Sayeh F ^a   Heinämäki, Jyrki ^b   Sande, Sverre A ^a   Graffner, Christina ^c  

^a UNIVERSITY OF OSLO   (Norway)

^b UNIVERSITY OF HELSINKI   (Finland)

^c MEDICAL PRODUCTS AGENCY   (Sweden)

Author keywords

Colonic delivery; Delayed release coating; Dissolution; Matrix tablets; Neutron activation; Samarium salts

Indexed keywords

AMIDATED PECTIN; EUDRAGIT; HYDROXYPROPYLMETHYLCELLULOSE; MAGNESIUM STEARATE; MICROCRYSTALLINE CELLULOSE; PECTIN; POLYMER; ROPIVACAINE; SAMARIUM; SAMARIUM 153; SAMARIUM OXIDE; SAMARIUM STEARATE; UNCLASSIFIED DRUG;

AMIDATION; ARTICLE; COLON; CONCENTRATION RESPONSE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DISSOLUTION; DRUG DELIVERY SYSTEM; DRUG RELEASE; LUBRICATION; MATRIX TABLET; MECHANICAL STRESS; MODEL; NEUTRON ACTIVATION ANALYSIS; NEUTRON RADIATION; PRIORITY JOURNAL; RADIOACTIVITY; SCANNING ELECTRON MICROSCOPY; TABLET COMPRESSION;

AMIDES; ANALYSIS OF VARIANCE; CHEMISTRY, PHYSICAL; COLON; DRUG COMPOUNDING; EXCIPIENTS; HARDNESS; LACTOSE; METHYLCELLULOSE; MICROSCOPY, ELECTRON, SCANNING; NEUTRONS; OXAZINES; PECTINS; POLYMETHACRYLIC ACIDS; SAMARIUM; SOLUBILITY; STEARATES; TABLETS;

EID: 0342748740     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(00)00070-1     Document Type: Article

References (24)

1. Abuzarur-Aloul R., Gjellan K., Sjölund M., Graffner C. Critical dissolution tests of oral systems based on statistically designed experiments. III. In vitro/in vivo correlation for multiple-unit capsules of paracetamol based on PLS modeling. Drug Dev. Ind. Pharm. 24:1998;371-383.
2. Ahrabi S.F., Sande S.A., Waaler T., Graffner C. Influence of neutron activation factors on the physico-chemical properties of suppositories and their excipients. Eur. J. Pharm. Sci. 8:1999;193-201.
3. Ahrabi S.F., Sande S.A., Waaler T., Graffner C. Effects of thermal neutron irradiation on some potential excipients for colonic delivery systems. Drug Dev. Ind. Pharm. 25:1999;453-462.
4. Ahrabi, S.F., Madsen, G., Dyrstad, K., Sande, S.A., Graffner, C., 1999c. Development of pectin matrix tablets for colonic delivery of model drug ropivacaine. Eur. J. Pharm. Sci. (in press).
5. Ashford M., Fell J.T. Targeting drugs to the colon: delivery systems for oral administration. J. Drug Targeting. 2:1994;241-258.
6. Bolhuis G.K., Lerk C.F., Zijlstra H.T., de Boer A.H. Film formation by magnesium stearate during mixing and its effect on tabletting. Pharm. Weekbl. 110:1975;317-325.
7. Colombo P., Bettini R., Massimo G., Catellani P.L., Santi P., Peppas N. Drug diffusion front movement is important in drug release control from swellable matrix tablets. J. Pharm. Sci. 84:1995;991-997.
8. Digenis G.A., Sandefer E. Gamma scintigraphy and neutron activation techniques in the in vivo assessment of orally administered dosage forms. Crit. Rev. Ther. Drug Carrier Syst. 7:1991;309-345.
9. Dobetti L., Esposito P., Boltri L. New lanthanide organic salts suitable for neutron activation. Eur. J. Pharm. Biopharm. 40:1994;161-167.
10. Esbensen K., Midtgaard T., Schönkopf S. Multivariate Analysis in Practice. 1994;Camo AS, Wennbergs, Trondheim.
11. Esposito P., Dobetti L., Boltri L., Rabaglia L. Use of a novel neutron activable excipient (samarium stearate) as lubricant in tablets. Eur. J. Pharm. Biopharm. 40:1994;341-343.
12. Holloway W.D., Tasman-Jones C., Maher K. Pectin digestion in humans. Am. J. Clin. Nutr. 37:1983;253-255.
13. Johansson M.E. Influence of the granulation technique and starting material properties on the lubricating effect of granular magnesium stearate. J. Pharm. Pharmacol. 37:1985;681-685.
14. Leopold C.S. Coated dosage forms for colon-specific drug delivery. Pharm. Sci. Tech. Today. 2:1999;197-204.
15. Lerk C.F., Bolhuis G.K., Smedema S.S. Interaction of lubricants and colloidal silica during mixing with excipients. Pharm. Acta Helv. 52:1977;33-44.
16. Nicklasson M., Magnusson A.-B. Program for evaluating drug dissolution kinetics in preformulation. Pharm. Res. 6:1985;262-266.
17. Nixon P. Understanding HPMC-based extended-release matrices: drug, polymer and compositional effects. CRS Workshop on Technology, Design and Evaluation of Oral Controlled-release Dosage Forms, Baltimore :1996.
18. Paronen P., Julsin M. Tabletoinnin fysikaaliset parametrit. Acta Pharm. Fenn. 91:1982;19-31.
19. Parr A., Jay M. Radiolabeling of intact dosage forms by neutron activation: effects on in vitro performance. Pharm. Res. 4:1987;524-526.
20. Reynolds T.D., Gehrke S.H., Hussain A.S., Shenouda L. Polymer erosion and drug release characterization of hydroxypropyl methylcellulose matrices. J. Pharm. Sci. 87:1998;1115-1123.
21. Steed K.P., Hooper G., Ventura P., Musa R., Wilding I.R. The in vivo behaviour of a colonic delivery system: a pilot study in man. Int. J. Pharm. 112:1994;199-206.
22. Waaler T., Sande S.A., Müller B.W., Lisether G.S. Influence of coating thickness and type of oral delivery system (tablets, pellets) on the stability towards degradation by neutron irradiation. Validation of neutron activation III. Eur. J. Pharm. Sci. 7:1999;295-303.
23. Watts P.J., Wilson C.G., Davies M.C., Melia C.D. Radiolabelling of polymer microspheres for scintigraphic investigations by neutron activation. 2. Effects of irradiation on the properties of Eudragit RS-sulphasalazine microspheres. Int. J. Pharm. 98:1993;63-73.
24. Watts P.J., Wilson C.G., Davies M.C., Melia C.D. Radiolabelling of polymer microspheres for scintigraphic investigations by neutron activation. 3. Changes in the physical properties of Eudragit RS-sulfapyridine microspheres from incorporating samarium oxide. Int. J. Pharm. 98:1993;75-82.