Mechanistic studies on the selective inhibition of cyclooxygenase-2 by indanone derivatives

Biochemical Pharmacology

Volumn 51, Issue 3, 1996, Pages 285-290

  Klein, Thomas ^a   Nüsing, Rolf M ^a   Wiesenberg Boettcher, Irmgard ^a,b   Ullrich, Volker ^a  

^a UNIVERSITY OF KONSTANZ   (Germany)

^b CIBA GEIGY LTD   (Switzerland)

Author keywords

arachidonic acid; cyclooxygenase; methansulfonilide; nonsteriodal anti inflammatory drugs; prostanoids; rat mesangial cells

Indexed keywords

5 METHYLSULFONAMIDO 6 PHENOXY 1 INDANONE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; FLOSULIDE; FLURBIPROFEN; INDANONE DERIVATIVE; INDOMETACIN; ISOENZYME; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; PROSTANOID; RADIOISOTOPE; SCHIFF BASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARACHIDONIC ACID METABOLISM; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SELECTIVITY; ENZYME BINDING; ENZYME INHIBITION; ENZYME PURIFICATION; ENZYME SUBUNIT; MESANGIUM CELL; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION;

EID: 0342716460     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(95)02170-1     Document Type: Article

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