Hybrid hepatitis B virus core antigen as a vaccine carrier moiety: I. Presentation of foreign epitopes

Journal of Biotechnology

Volumn 44, Issue 1-3, 1996, Pages 91-96

  Schodel F ^a   Peterson, D ^b   Hughes, J ^d   Wirtz, R ^c   Milich, D ^d  

^a EDOUARD HERRIOT HOSPITAL   (France)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Circumsporozoite antigen; Core particle; Epitope presentation; HBcAg; Hepatitis B virus; Malaria; Malaria vaccine

Indexed keywords

AMINO ACIDS; COLIFORM BACTERIA; DISEASES; GENETIC ENGINEERING; IMMUNIZATION; IMMUNOLOGY; PARTICLES (PARTICULATE MATTER); VACCINES; VIRUSES;

ANTIGENICITY; CIRCUMSPOROZOITE ANTIGEN; CORE PARTICLE; EPITOPES; HEPATITIS B VIRUS; IMMUNOGENICITY; MALARIA; VACCINE CARRIER MOIETY;

ANTIGENS;

CARRIER PROTEIN; CORE PROTEIN; EPITOPE; HEPATITIS B CORE ANTIGEN; HEPATITIS B VACCINE; MALARIA VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; CONTROLLED STUDY; HEPATITIS B VIRUS; MALARIA; MOLECULAR CLONING; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; VACCINATION;

EID: 0342655940     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/0168-1656(95)00118-2     Document Type: Conference Paper

References (14)

1. Borisova, G., Biragyn, A., Dislers, A., Borschukova, O., Tsibinogin, V., Skrastina, D., Eldarov, M.A., Pumpens, P., Skryabin, K.G. and Grens, E. (1993) Hybrid hepatitis-B virus nucleocapsid bearing an immunodominant region from hepatitis-B virus surface-antigen. J. Virol. 67, 3696-3701.
2. Clarke, B.E., Newton, S.E., Carroll, A.R., Francis, M.J., Appleyard, G., Syred, D., Highfield, P.E., Rowlands, D.J. and Brown, F. (1987) Improved immunogenicity of a peptide epitope after fusion to hepatitis B core protein. Nature 330, 381-384.
3. Charoenvit, Y., Mellouk, S., Cole, C., Bechara, R., Leef, M.F., Sedegah, M., Yuan, L.F., Robey, F.A., Beaudoin, R.L. and Hoffman, S. (1991) Monoclonal, but not polyclonal, antibodies protect against Plasmodium yoelii sporozoites. Infect. Immun. 146, 1020-1025.
4. Crowther, R.A., Kiselev, N.A., Böttcher, B., Berriman, J.A., Borisova, G.P., Ose, V. and Pumpens, P. (1994) Three-dimensional structure of hepatitis B virus core particles determined by electron microscopy. Cell 77, 943-950.
5. Herzenberg, L.A. and Tokuhisa, T. (1983) Epitope-specific regulation. I. carrier-specific induction of suppression for IgG anti-hapten antibody response. J. Exp. Med. 155, 1730.
6. Milich, D.R. and McLachlan, A. (1986) The nucleocapsid of the hepatitis B virus is both a T-cell in dependent and a T-cell dependent antigen. Science 234, 1398.
7. Milich, D.R., McLachlan, A., Moriarty, A. and Thornton, G.B. (1987a) Immune responses to hepatitis B virus core antigen (HBcAg): localization of T cell recognition sites within HBcAg/HBeAg. J. Immunol. 139, 1223.
8. Milich, D.R., McLachlan, A., Thornton, G.B. and Hughes, J.L. (1987b) Antibody production to the nucleocapsid and envelope of the hepatitis B virus primed by a single synthetic T cell site. Nature 329, 547-549.
9. Milich, D.R. (1988) T and B cell recognition of hepatitis B viral antigens. Immunol. Today 9, 380-386.
10. Schödel, F., Moriarty, A.M., Peterson, D.L., Zheng, J., Hughes, J.L., Will, H., Leturcq, D.J., McGee, J.S. and Milich, D.R. (1992) The position of heterologous epitopes inserted in hepatitis B virus core particles determines their immunogenicity. J. Virol. 66, 106-114.
11. Schödel, F., Peterson, D., Hughes, J. and Milich, D.R. (1994a) Hepatitis B virus core particles as a vaccine carrier moiety. Int. Rev. Immunol. 11, 153-164.
12. Schödel, F., Wirtz, R., Peterson, D., Hughes, J., Warren, R., Sadoff, J. and Milich, D. (1994b) Immunity to malaria elicited by hybrid hepatitis B virus core particles carrying circumsporozoite protein epitopes. J. Exp. Med. 180, 1037-1046.
13. Schödel, F., Peterson, D., Charoenvit, Y., Sadoff, J. and Wirtz, R. (1995a) Immunity to Plasmodium yoelii infection elicited by hybrid hepatitis B virus core particles (HBcAg) carrying circumsporozoite antigen epitopes. 95th ASM General Meeting, Washington DC, Abstr. E61.
14. Schödel, F., Kelly, S., Tinge, S., Hopkins, S., Peterson, D. and Curtiss, R. (1995b) Hybrid hepatitis B virus core antigens as a vaccine carrier moiety: II. Expression in avirulent Salmonella spp. for mucosal immunization. In: Shafferman, A. and Cohen, S. (Eds.), Vaccines: Novel Strategies in Design and Production. Proceedings of the 39th OHOLO Conference -1995. Plenum Press, New York, in press.