The early protective effects of L-arginine and Ng-nitro-L-arginine methyl ester after experimental acute spinal cord injury. A light and electron microscopic study

Journal of Clinical Neuroscience

Volumn 7, Issue 3, 2000, Pages 238-243

  Yüceer, Nurullah ^a   Attar, Ayhan ^b   Sargon, Mustafa F ^c   Egemen, Nihat ^b   Türker, R Kazim ^b   Demirel, Emine ^b  

^a DOKUZ EYLUL UNIVERSITY   (Turkey)

^b ANKARA UNIVERSITY   (Turkey)

^c HACETTEPE UNIVERSITY   (Turkey)

Author keywords

Electron microscopy; L arginine; Ng nitro L arginine methyl ester; Spinal cord injury

Indexed keywords

ARGININE; ARGININE METHYL ESTER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG EFFECT; MALE; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RABBIT; SPINAL CORD INJURY;

EID: 0342646908     PISSN: 09675868     EISSN: None     Source Type: Journal    
DOI: 10.1054/jocn.1999.0210     Document Type: Article

References (43)

1. Kapadia S. E. Ultrastructural alterations in blood vessels of the white matter after experimental spinal cord trauma. J Neurosurg. 61:1984;539-544.
2. Koyanagi I., Tator C. H., Lea P. J. Three-dimensional analysis of the vascular system in the rat spinal cord with scanning electron microscopy of vascular corrosion casts. Part I: Normal spinal cord. Neurosurgery. 33:1993;277-284.
3. Koyanagi I., Tator C. H., Lea P. J. Three-dimensional analysis of the vascular system in the rat spinal cord with scanning electron microscopy of vascular corrosion casts. Part 2: Acute spinal cord injury. Neurosurgery. 33:1993;285-292.
4. Nelson E., Gertz S. D., Rennels M. L., Ducker T. B., Blaumanis D. R. Spinal cord injury: The role of vascular damage in the pathogenesis of central hemorrhagic necrosis. Arch Neurol. 34:1977;332-333.
5. Sasaki S. Vascular change in the spinal cord after impact injury in the rat. Neurosurgery. 10:1982;360-363.
6. Tator C. H., Fehlings M. G. Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms. J Neurosurg. 75:1991;15-26.
7. Tator C. H., Koyanagi I. Vascular mechanisms in the pathophysiology of human spinal cord injury. J Neurosurg. 86:1997;483-492.
8. Yamada T., Morimoto T., Nakase H., Hirabayashi H., Hiramatsu K., Sakaki T. Spinal cord blood flow and pathophysiological changes after transient spinal cord ischemia in cats. Neurosurgery. 42:1998;626-634.
9. Tator C. H. Review of experimental spinal cord injury with emphasis on the local and systemic circulatory effects. Neurochiurgie. 37:1991;291-302.
10. Anthes D. L., Theriault E., Tator C. H. Ultrastructural evidence for arteriolar vasospasm after spinal cord trauma. Neurosurgery. 39:1996;804-814.
11. Senter H. J., Venes J. L. Loss of autoregulation and posttraumatic ischaemia following experimental spinal cord trauma. J Neurosurg. 50:1979;198-206.
12. Faden A. L., Jacobs T. P., Patrick D. H., Smith M. T. Megadose corticosteroid therapy following experimental traumatic spinal injury. J Neurosurg. 60:1984;712-717.
13. Hall E. D., Braughler J. M. Effects of intravenous methylprednisolone on spinal cord lipid peroxidation and (Na+ K-) ATP ase activity. J Neurosurg. 57:1982;247-253.
14. Means E. D., Anderson D. K., Waters T. R., Kalaf L. Effect of methylprednisolone in compression trauma to the feline spinal cord. J Neurosurg. 55:1981;200-208.
15. Ross I., Tator C. H., Theriault H. E. Effect of nimodipine or methylprednisolone on recovery from acute experimental spinal cord injury in rats. Surg Neurol. 40:1993;461-470.
16. Fehlings M. G., Tator C. H., Linden R. D. The effect of nimodipine and dextran on axonal function and blood flow following experimental spinal cord injury. J Neurosurg. 71:1989;403-416.
17. Haghighi S. S., Stiens T., Oro J. J., Madsen R. Evaluation of the calcium channel antagonist nimodipine after experimental spinal cord injury. Surg Neurol. 39:1993;403-408.
18. Griffiths I. R. Spinal cord blood flow after acute experimental cord injury in dogs. J Neurol Sci. 27:1976;247-259.
19. Guha A., Tator C. H., Piper I. Effect of a calcium channel blocker on posttraumatic spinal cord blood flow. J Neurosurg. 66:1987;423-430.
20. Rivlin A. S., Tator C. H. Regional spinal cord blood flow in rats after severe cord trauma. J Neurosurg. 49:1978;844-853.
21. Wallace M. C., Tator C. H. Spinal cord blood flow measures with microspheres following spinal cord injury in the rat. Can J Neurol Sci. 13:1986;91-96.
22. Sandler A. N., Tator C. H. Effect of acute spinal cord compression injury on regional spinal cord blood flow in primates. J Neurosurg. 45:1976;660-676.
23. Sandler A. N., Tator C. H. Review of the effect of spinal cord trauma on the vessels and blood flow in the spinal cord. J Neurosurg. 45:1976;638-646.
24. Furchgott R. F., Zawadzki J. V. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 288:1980;373-376.
25. Beckman J. S. The double-edged role of nitric oxide in brain function and superoxide-mediated injury. J Dev Physiol. 15:1991;53-55.
26. Beckman J. S., Beckman T. W., Chen J., Marshall P. A., Freeman B. A. Apparent hydroxyl radical production by peroxynitrite. Implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA. 87:1990;1620-1624.
27. Muhonen M. G., Heistad D. D., Faraci F. M., Loftus C. M. Augmentation of blood flow through cerebral collaterals by inhibition of nitric oxide synthase. J Cereb Blood Metab. 14:1994;704-714.
28. Nishimura H., Rosenblum W. I., Nelson G. H., Bonyton S. Agents that modify EDRF formation after antiplatelet properties of brain arteriolar endothelium in vivo. Am J Physiol. 261:1991;H15-H21.
29. Rosenblum W. I., Nishimura H., Nelson G. H. Endothelium dependant L - arg - and L - NMMA - sensitive mechanisms regulate tone of brain microvessels. Am J Physiol. 259:1990;H1396-H1401.
30. Morikawa H., Huang Z., Moskowitz M. A. L-arginine decreases infarct size caused by middle cerebral arterial occlusion is SHR. Am J Physiol. 263:1992;H1632-H1635.
31. Morikawa E., Moskowitz M. A., Huang Z., Yoshida T., Irikura K., Dalkara T. L-arginine infusion promotes nitric oxide-dependent vasodilation, increases regional cerebral blood flow, and reduces infarction volume in the rat. Stroke. 25:1994;429-435.
32. Zhang F., Iadecola C. Nitroprusside improves blood flow and reduces brain damage after focal ischaemia. Neuroreport. 4:1993;559-562.
33. Rees D. D., Palmer R. M. J., Shulz R., Hodson H. F., Moncada S. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br J Pharmacol. 101:1990;746-752.
34. Hitchon P. W., Mouw L. J., Rogge T. N., Torner J. C., Miller A. K. Response of spinal cord blood flow to the nitric oxide inhibitor nitroarginine. Neurosurgery. 39:1996;795-803.
35. Fried L. C., Goodkin R. Microangiographic observations of the experimentally traumatized spinal cord. J Neurosurg. 35:1971;709-714.
36. Nemecek S. T. Morphological evidence of microcirculatory disturbances in experimental spinal cord trauma. Adv Neurol. 20:1978;395-405.
37. Balentine J. D., Paris D. U. Pathology of experimental spinal cord trauma. I. The necrotic lesion as a function of vascular injury. Lab Invest. 39:1978;236-253.
38. Garthwaite J. Glutamate, nitric-oxide, and cell-cell signalling in the nervous system. TINS (Trends Neurosci). 14:1991;60-67.
39. Busija D. W., Leffler C. W., Wagerle L. C. Mono-L-arginine-containing compounds dilate piglet pial arterioles via an endothelium-derived relaxing factor-like substance. Circ Res. 67:1990;1374-1380.
40. Faraci F. M. Role of nitric oxide in regulation of basilar artery tone in vivo. Am J Physiol. 259:1980;H1216-H1221.
41. Faraci F. M. Role of endothelium-derived relaxing factor in cerebral circulation: large arteries vs microcirculation. Am J Physiol. 261:1991;H1038-H1042.
42. Faraci F. M., Breese K. R., Heistad D. D. Nitric oxide contributes to dilatation of cerebral arterioles during seizures. Am J Physiol. 265:1993;H2209-H2212.
43. Faraci F. M., Heistad D. D. Role of ATP-sensitive potassium-channels in the basilar artery. Am J Physiol. 264:1992;H8-H13.