Effects of UP269-6, a new angiotensin II receptor antagonist, and captopril on the progression of rat diabetic nephropathy

American Journal of Hypertension

Volumn 10, Issue 3, 1997, Pages 275-281

  Villa, Eduardo ^a   Rábano, Alberto ^b   Cazes, Michèlle ^d   Cloarec, Alix ^d   Ruilope, Luis M ^c   García Robles, Rafael ^a  

^a HOSPITAL RAMÓN Y CAJAL   (Spain)

^b HOSPITAL INFANTIL UNIVERSITARIO NIÑO JESÚS   (Spain)

^c HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^d UPSA Laboratories   (France)

Author keywords

angiotensin II receptor; blood pressure; captopril; diabetes mellitus; renal derangement; UP269 9; Wistar rat

Indexed keywords

5 METHYL 7 PROPYL 8 [[2' (1H TETRAZOL 5 YL) 4 BIPHENYLYL]METHYL] 1,2,4 TRIAZOLO[1,5 C]PYRIMIDIN 2(3H) ONE; ANGIOTENSIN RECEPTOR ANTAGONIST; CAPTOPRIL; NEW DRUG; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DRUG EFFECT; HISTOLOGY; INTRAGASTRIC DRUG ADMINISTRATION; KIDNEY INJURY; NONHUMAN; PRIORITY JOURNAL; PROTEINURIA; RAT;

ALBUMINURIA; ANGIOTENSIN II; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; BLOOD GLUCOSE; BLOOD PRESSURE; CAPTOPRIL; CREATININE; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; DISEASE PROGRESSION; KIDNEY; NEPHRECTOMY; PYRIMIDINES; RATS; RATS, WISTAR; RECEPTORS, ANGIOTENSIN; TETRAZOLES;

EID: 0342601934     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0895-7061(96)00380-9     Document Type: Article

References (30)

1. Eggers PW. Effect of transplantation on Medicare end-stage renal disease program. N Engl J Med. 318:1988;223-229.
2. Raine AEG, Margreiter R, Brunner FP, et al. Report on management of renal failure in Europe. XXII 1991 Nephrol Dial Transplant. 72:((suppl)):1992;7-35.
3. Parving HH, Andersen AR, Smidt UM, et al. Effect of antihypertensive treatment on kidney function in diabetic nephropathy. Br Med J. 294:1987;1443-1447.
4. Bakris GL. Hypertension in diabetic patients: an overview of international studies to preserve renal function. Am J Hypertens. 6:1993;140S-147S.
5. Anderson S. Antihypertensive therapy in experimental diabetes. J Am Soc Nephrol. 3:1992;S86-S90.
6. Slataper R, Vicknair N, Sadler R, et al. Comparative effects of different antihypertensive treatments on progression of diabetic renal disease. Arch Intern Med. 153:1993;973-980.
7. Anderson SH, Rennke G, Brenner BM. Nifedipine versus fosinopril in uninephrectomized diabetic rats. Kidney Int. 4:1992;891-897.
8. Lewis EJ, Hunsicker LG, Bain RP, et al. The effect of angiotensin-converting enzyme inhibition on diabetic nephropathy. N Engl J Med. 329:1993;1456-1462.
9. Anderson S, Rennke HG, Brenner BM. Therapeutic advantage of converting enzyme inhibitors in arresting progressive renal disease associated with systemic hypertension in the rat. J Clin Invest. 77:1986;1993-2000.
10. Raij L, Keane WF. Glomerular mesangium: its function and relationship to angiotensin II. Am J Med. 79:1985;24-30.
11. Remuzzi A, Puntorieri S, Battaglia C, et al. Angiotensin converting enzyme inhibition ameliorates glomerular filtration of macromolecules and water and lessens glomerular injury in rat. J Clin Invest. 85:1990;541-549.
12. Hall JH. Regulation of glomerular filtration and sodium excretion by angiotensin II. Fed Proc. 45:1986;1431-1437.
13. Chou S-Y, Faubert PF, Porush JH. Contribution of angiotensin to the control of medullary hemodynamics. Fed Proc. 45:1986;1438-1443.
14. Remuzzi A, Perico N, Amuchastegui CS. Short and long-term effect of angiotensin II receptor blockade in rats with experimental diabetes. J Am Soc Nephrol. 4:1993;40-49.
15. Kohzuki M, Yasujima M, Kanazawa M, et al. Antihypertensive and renal-protective effects of losartan in streptozotocin diabetic rats. J Hypertens. 13:1995;97-103.
16. Lafayette RA, Mayer G, Park SK, et al. Angiotensin II blockade limits glomerular injury in rats with reduced renal mass. J Clin Invest. 90:1992;766-771.
17. Kakinuma Y, Kawamura T, Bills T, et al. Blood pressure independent effect of angiotensin inhibition on vascular lesions of chronic renal failure. Kidney Int. 42:1992;46-55.
18. Cazes M, Provost D, Versigny A, et al. In vivo pharmacological characterization of UP 269-6, a novel nonpeptide angiotensin II receptor antagonist. Eur J Pharmacol. 284:1995;157-170.
19. Steffes MW, Braun DM, Mauer SM. Diabetic glomerulopathy following unilateral nephrectomy in the rat. Diabetes. 27:1978;35-41.
20. O'Donnell MP, Kasiske BL, Daniels FX, et al. Effects of nephron loss on glomerular hemodynamics and morphology in diabetic rats. Diabetes. 35:1986;1011-1015.
21. Epstein M, Sowers JR. Diabetes mellitus and hypertension. Hypertension. 19:1992;403-418.
22. Parving HH, Hommel E, Nielsen MD, Giese J. Effect of captopril on blood pressure reduction and kidney function in normotensive, insulin-dependent diabetics with nephropathy. Br Med J. 299:1989;533-536.
23. Parving HH, Hommel E, Smidt UM. Protection of kidney function and decrease in albuminuria by captopril in insulin dependent diabetics with nephropathy. Br Med J. 297:1988;1086-1091.
24. Morelli E, Loon N, Meyer TW, Peters W, Myers BD. Effects of converting enzyme inhibition on barrier function in diabetic glomerulopathy. Diabetes. 39:1990;76-82.
25. 2 inhibition on the renal hemodynamics in streptozotocin-induced diabetic rats. Kidney Int. 45:1994;794-802.
26. Craven PA, De Rubertis FR. Suppression of urinary albumin excretion in diabetic rats by 4′(imidazole-l-yl) acetophenone: a selective inhibitor of thromboxane synthesis. J Lab Clin Med. 116:1990;469-478.
27. Robles RG, Villa E, Rábano A, et al. Effect of cicaprost on the progression of diabetic nephropathy in uninephrectomized streptozotocin-induced diabetic rats. J Hypertens. 11:((suppl 5)):1993;S208-S209.
28. Villa E, Rábano A, Ruilope LM, et al. Effects of cicaprost and fosinopril on the progression of rat diabetic nephropathy. Am J Hypertens. 10:1997;202-208.
29. Crary GS, Swan SK, O'Donnell MP, et al. The angiotensin II receptor antagonist losartan reduces blood pressure but not renal injury in obese Zucker rats. J Am Soc Nephrol. 6:1995;1295-1299.
30. Anderson S, Jung FF, Ingelfinger JR. Renal renin-angiotensin system in diabetes: functional, immunohistochemical, and molecular biological correlations. Am J Physiol. 265:1993;F477-F483.