The enantiomeric purity of alcohols formed by enzymatic reduction of ketones can be improved by optimisation of the temperature and by using a high co-substrate concentration

Biochimica et Biophysica Acta - General Subjects

Volumn 1336, Issue 1, 1997, Pages 51-58

  Yang, Hong ^a,b   Jönsson, Åsa ^a   Wehtje, Ernst ^a   Adlercreutz, Patrick ^a   Mattiasson, Bo ^a  

^a LUND UNIVERSITY   (Sweden)

^b JILIN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DEHYDROGENASE; ALCOHOL DERIVATIVE;

ARTICLE; DRUG PURITY; DRUG SYNTHESIS; ENANTIOMER; ENTHALPY; ENTROPY; ENZYME ACTIVITY; GAS CHROMATOGRAPHY; IN VITRO STUDY; PRIORITY JOURNAL; REDUCTION; STEREOCHEMISTRY; TEMPERATURE;

1-PROPANOL; ALCOHOL DEHYDROGENASE; BACTERIA; BUTANOLS; BUTANONES; COLD; KINETICS; OSMOLAR CONCENTRATION; STEREOISOMERISM; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

THERMOANAEROBACTER BROCKII;

EID: 0342601433     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-4165(97)00010-X     Document Type: Article

References (18)

1. Koskinen, A.M.P. and Klibanov, A.M. (Eds.) (1996) Enzymatic Reactions in Organic Media, Blackie Academic and Scientific, London.
2. Fink, A.L. (1973) Biochemistry 12, 1736-1742.
3. Jönsson, Å., Adlercreutz, P. and Mattiasson, B. (1995) Biotechnol. Bioeng. 46, 429-436.
4. Jönsson, Å., Wehtje, E., Adlercreutz, P. and Mattiasson, B. (1996) J. Mol. Catalysis. B Enzym. 2, 43-51.
5. Hummel, W. and Kula, M.-R. (1989) Eur. J. Biochem. 184, 1-13.
6. Adlercreutz, P. (1996) Biocatal. Biotrans., in press.
7. Pham, V.T. and Phillips, R.S. (1989) J. Am. Chem. Soc. 111, 1935-1936.
8. Pham, V.T. and Phillips, R.S. (1990) J. Am. Chem. Soc. 112, 3629-3632.
9. Phillips, R.S. (1992) Enz. Microb. Technol. 14, 417-419.
10. Phillips, R.S. (1996) Trends Biotechnol. 14, 13-16.
11. van Osselaer, T.A., Lemière, G.L., Lepoivre, J.A. and Alderweireldt, F.C. (1978) J. Chem. Soc. Perkin Trans. II 1978, 1181-1188.
12. Adolph, H.W., Maurer, P., Schneider-Bernlöhr, H., Sartorius, C. and Zeppezauer, M. (1991) Eur. J. Biochem. 201, 615-625.
13. Chen, C.-S., Fujimoto, Y, Girdaukas, G. and Sih, C.J. (1982) J. Am. Chem. Soc. 104, 7294-7299.
14. Keinan, E., Hafeli, E.K., Seth, K.K. and Lamed, R. (1986) J. Am. Chem. Soc. 108, 162-169.
15. Howaldt, M., Gottlob, A., Kulbe, K.D. and Chmiel, H. (1988) Ann. N.Y. Acad. Sci. 542, 400-405.
16. Wichmann, R., Wandrey, C., Bückmann, A. and Kula M.-R. (1981) Biotechnol. Bioeng. 23, 2789-2802.
17. Martinek, K., Klyachko, N.L., Kabanov, A.V., Khmelnitsky, Yu.L. and Levashov, A.V. (1989) Biochim. Biophys. Acta 981, 161-172.
18. Ottolina, G., Bovara, R., Riva, S. and Carrea, G. (1994) Biotechnol. Lett. 16, 923-928.