A proposed model for the PEX5-peroxisomal targeting signal-1 recognition complex

Proteins: Structure, Function and Genetics

Volumn 38, Issue 3, 2000, Pages 241-246

  Gatto Jr , Gregory J ^a   Geisbrecht, Brian V ^a   Gould, Stephen J ^a   Berg, Jeremy M ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Asparagine; Molecular recognition; Peptide binding; Structure prediction; Tetratricopeptide repeat (TPR)

Indexed keywords

ASPARAGINE; M PROTEIN; POLYPEPTIDE; RECEPTOR;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; MOLECULAR MODEL; MOLECULAR RECOGNITION; PREDICTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; FUNGAL PROTEINS; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEROXISOMES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SEQUENCE ALIGNMENT;

EID: 0342576245     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0134(20000215)38:3<241::AID-PROT1>3.0.CO;2-1     Document Type: Article

References (21)

1. van den Bosch H, Schutgens RBH, Wanders RJA, Tager JM. Biochemistry of peroxisomes. Annu Rev Biochem 1992;61:157-197.
2. Subramani S. Protein import into peroxisomes and biogenesis of the organelle. Annu Rev Cell Biol 1993;9:445-478.
3. McCollum D, Monosov E, Subramani S. The pas8 mutant of Pichia pastoris exhibits the peroxisomal protein import deficiencies of Zellweger syndrome cells - the PAS8 protein binds to the COOH-terminal tripeptide peroxisomal targeting signal, and is a member of the TPR protein family. J Cell Biol 1993;121:761-774.
4. Van der Leij I, Franse MM, Elgersma Y, Distel B, Tabak HF. PAS10 is a tetratricopeptide-repeat protein that is essential for the import of most matrix proteins into peroxisomes of Sacccharomyces cerevisiae. Proc Natl Acad Sci USA 1993;90:11782-11786.
5. Dodt G, Braverman N, Wong C, et al. Mutations in the PTS1 receptor gene, PXR1, define complementation group 2 of the peroxisome biogenesis disorders. Nat Genet 1995;9:115-125.
6. Lamb JR, Tugendreich S, Hieter P. Tetratricopeptide repeat interactions: to TPR or not to TPR? Trends Biochem Sci 1995;20: 257-259.
7. Goebl M, Yanagida M. The TPR snap helix: a novel protein repeat motif from mitosis to transcription. Trends Biochem Sci 1991;16: 173-177.
8. Das AK, Cohen PTW, Barford D. The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions. EMBO J 1998;17:1192-1199.
9. +. Cell 1990;60:319-328.
10. Sikorski RS, Boguski MS, Goebl M, Hieter P. A repeating amino acid motif in CDC23 defines a family of proteins and a new relationship among genes required for mitosis and RNA synthesis. Cell 1990;60:307-317.
11. Terlecky SR, Nuttley WM, McCollum D, Sock E, Subramani S. The Pichia pastoris peroxisomal protein PAS8p is the receptor for the C-terminal tripeptide peroxisomal targeting signal. EMBO J 1995;14:3627-3634.
12. Conti E, Uy M, Leighton L, Blobel G, Kuriyan J. Crystallographic analysis of the recognition of a nuclear localization signal by the nuclear import factor karyopherin α. Cell 1998;94:193-204.
13. McGregor MJ, Islam SA, Sternberg MJE. Analysis of the relationship between side-chain conformation and secondary structure in globular proteins. J Mol Biol 1987;198:295-310.
14. Ponder JW, Richards FM. Tertiary templates for proteins: use of packing criteria in the enumeration of allowed sequences for different structural classes. J Mol Biol 1987;193:775-791.
15. Brünger AT. X-PLOR Version 3.1: a system for X-ray crystallography and NMR. New Haven, CT: Yale University Press; 1992.
16. Stern LJ, Brown JH, Jardetzky TS, Gorga JC, Urban RG, Strominger JL, Wiley DC. Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature 1994;368:215-221.
17. Braverman N, Dodt G, Gould SJ, Valle D. An isoform of Pex5p, the human PTS1 receptor, is required for the import of PTS2 proteins into peroxisomes. Hum Mol Genet 1998;7:1195-1205.
18. Russell LC, Whitt SR, Chen M-S, Chinkers M. Identification of conserved residues required for the binding of a tetratricopeptide repeat domain to heat shock protein 90. J Biol Chem 1999;274: 20060-20063.
19. Purdue PE, Lazarow PB. Targeting of human catalase to peroxisomes is dependent upon a novel COOH-terminal peroxisomal targeting signal. J Cell Biol 1996;134:849-862.
20. Amery L, Brees C, Baes M, Setoyama C, Miura R, Mannaerts GP, Van Veldhoven PP. C-terminal tripeptide Ser-Asn-Leu (SNL) of human D-aspartate oxidase is a functional peroxisome targeting signal. Biochem J 1998;336:367-371.
21. Kraulis PJ. MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures. J Appl Crystallogr 1991;24: 946-950.