The relationships among saccharin consumption, oral ethanol, and IV cocaine self-administration

Pharmacology Biochemistry and Behavior

Volumn 53, Issue 4, 1996, Pages 919-925

  Gahtan, Ethan ^a   Labounty, Lynda Paulson ^a   Wyvell, Cindy ^b   Carroll, Marilyn E ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b MACALESTER COLLEGE   (United States)

Author keywords

Cocaine; Ethanol; IV; Oral; Rats; Saccharin; Self administration

Indexed keywords

ALCOHOL; COCAINE; SACCHARIN;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG SELF ADMINISTRATION; FOOD DEPRIVATION; INSTRUMENTAL CONDITIONING; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; REINFORCEMENT; SATIETY;

EID: 0342502242     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/0091-3057(95)02148-5     Document Type: Article

References (22)

1. Beczkowska, I.; Koch, J.; Bostock, M.; Leibowitz, S.; Bodnar, R. Central opioid receptor subtype antagonists differentially reduce intake of saccharin and maltose dextrin solutions in rats. Brain Res. 618:261-270; 1993.
2. Bell, M. S.; Gosnell, B. A.; Krahn, D. D.; Meisch, R. A. Ethanol reinforcement and its relationship to saccharin preference in rats. Alcohol 11(2)141-145; 1994.
3. Carroll, M. E.; France, C. P.; Meisch, R. A. Intravenous self-administration of etonitazene, cocaine, and phencyclidine in rats during food deprivation and satiation. J. Pharmacol. Exp. Ther. 217(2):241-247; 1981.
4. Carroll, M. E.; Lac, S. T. Autoshaping IV cocaine self-administration in rats: Effects of nondrug alternative reinforcers on acquisition. Psychopharmacology (Berlin) 110:5-12; 1993.
5. Carroll, M. E.; Lac, S. T.; Nygaard, S. L. A concurrently available nondrug reinforcer prevents the acquisition or decreases the maintenance of cocaine-reinforced behavior. Psychopharmacology (Berlin) 97:23-29; 1989.
6. Falk, J. L.; Tang, M. Schedule induction and overindulgence. Alcohol. Clin. Exp. Res. 4:266-270; 1980.
7. Ganchrow, J. R.; Lieblich, I.; Cohen, E. Consumatory responses to taste stimuli in rats selected for high and low rates of self-stimulation. Physiol. Behav. 27:971-976; 1981.
8. Gosnell, B. A.; Krahn, D. D. The relationship between saccharin and alcohol intake in rats. Alcohol 9:203-206; 1992.
9. Gosnell, B.; Lane, K. E.; Bell, S. M.; Krahn, D. D. Intravenous morphine self-administration by rats with low vs. high saccharin preferences. Psychopharmacology (Berlin) 117:248-252; 1995.
10. Kampov-Polevoy, A. B.; Kasheffskaya, O. P.; Sinclair, J. D. Initial acceptance of ethanol: Gustatory factors and patterns of Alcohol drinking. Alcohol 7:83-85; 1990.
11. Koob, G. F. Drugs of abuse: Anatomy, pharmacology and function of reward pathways. Trends Pharmacol. Sci. 13:177-185; 1992.
12. Koob, G. F.; Rassnick, S.; Heinrichs, S.; Weiss, F. Alcohol, the reward system and dependence. In: Jansson, B.; Jörnvall, H.; Rydberg, U.; Terenius, L.; Valle, B. L., eds. Toward a molecular basis of alcohol use and abuse. Basel, Switzerland: Birkhäusen Verlag; 1994:103-114.
13. Lynch, W. Opiate blockade inhibits saccharin intake and blocks normal preference acquisition. Pharmacol. Biochem. Behav. 24: 833-836; 1986.
14. McBride, W. J.; Murphy, J. M.; Gatto, G. J.; Levy, A. D.; Lumeng, L.; Li, T.-K. Serotonin and dopamine systems regulating alcohol intake. Alcohol Alcohol. Suppl. 1:411-416; 1991.
15. Nichols, J. R.; Hsiao, S. Addiction liability of albino rats: Breeding for quantitative differences in morphine drinking. Science 157:561-563; 1967.
16. Overstreet, D. H.; Kampov-Polevoy, A. B.; Rezvani, A. H.; Murrelle, L.; Halikas, J. A.; Janowsky, D. S. Saccharin intake predicts ethanol intake in genetically heterogeneous rats as well as different rat strains. Alcohol Clin. Exp. Res. 17(2):366-369; 1993.
17. Pettit, H. O.; Justice, J. B. Dopamine in the nucleus accumbens during cocaine self-administration as studied by in vivo microdialysis. Pharmacol. Biochem. Behav. 34:899-904; 1989.
18. Sinclair, J. D.; Kampov-Polevoy, A.; Stewart, R.; Li, T.-K. Taste preferences in rat lines selected for high and low alcohol consumption. Alcohol 9:155-160; 1992.
19. Touzani, K.; Akarid, K.; Velley, L. Modulation of saccharin preference by morphine and naloxone: Inversion of drug effects as a function of saccharin concentration. Pharmacol. Biochem. Behav. 38:37-41; 1991.
20. Waller, M. B.; McBride, W. J.; Gatto, G. J.; Lumeng, L.; Li, T.-K. Intragatric self-infusion of ethanol by ethanol-preferring and -nonpreferring lines of rats. Science 225:78-79;1984.
21. Weiss, F.; Hurd, Y. L.; Understedt, U.; Markou, A.; Plotsky, P. M.; Koob, G. F. Neurochemical correlates of cocaine and ethanol self-administration. Ann. NY Acad. Sci. 654:220-241; 1992.
22. Weiss, F.; Lorang, M. T.; Bloom, F. E.; Koob, G. F. Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: Genetic and motivational determinants. J. Pharmacol. Exp. Ther. 267(1):250-258; 1993.