Continuous Production of tPA by Recombinant BHK Cells in a Micro-Filtration Hollow Fiber Bioreactor

Seibutsu-kogaku Kaishi

Volumn 74, Issue 6, 1996, Pages 435-441

  Tanase, Takaaki ^a,b   Ikeda, Yasunori ^a   Iwama, Kiyoshi ^a   Hashimoto, Akira ^a   Kataoka, Tsunehiko ^a   Kobayashi, Takeshi ^b  

^a EISAI CO LTD   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

Author keywords

BHK cells; Mammalian cell culture; Micro filtration hollow fiber; tPA production

Indexed keywords

EID: 0342476576     PISSN: 09193758     EISSN: 24358630     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Pullen, K. F., Jonson, M. D., Phillips, A. W., Ball, G. D., and Finter, N. B.: Develop. Biol. Standard, 60, 175-177 (1985).
2. Knight, P.: Bio/Technol., 7, 459-461 (1989).
3. Knazek, R. A., Gullino, P. M., Kohler, P. O., and Dedrick, R. L.: Science, 178, 65-67 (1972).
4. Mancuso, A., Fernandas, E. J., Blanch, H. W., and Clark, D. S.: Bio/Technol., 8, 1282-1285 (1990).
5. Hopkinson, J.: Bio/Technol., 3, 225-230 (1985).
6. Lydersen, B. K., Pugh, G. G., Paris, M. S., Sharma, B. P., and Noll, L. A.: Bio/Technol., 3, 63-67 (1985).
7. Mckillip, E. R., Giles, A. S., Levner, M. H., Hung, P. P., and Hjorth, N.: Bio/Technol., 9, 805-810 (1991).
8. Knight, P.: Bio/Technol., 7, 459-461 (1989).
9. Ogata, M., Marumoto, T., Oh-i, K., Shimizu, S., and Kato, S.: J. Ferment. Bioeng., 7, 46-51 (1994).
10. Knazek, R. A., Kohler, P. O., and Gullino, P. M.: Experimental Cell Res., 84, 251-254 (1974).
11. Hopkinson, J.: Bio/Technol., 3, 225-230 (1985).
12. Piret, J. M. and Cooney, C. L.: Biotechnol. Bioeng., 36, 902-910 (1990).
13. Wang, J., Hata, M., Park, Y. S., Iijima, S., and Kobayashi, T.: J. Ferment. Bioeng., 78, 321-326 (1994).
14. Butler, M. and Spier, R. E.: J. Biotechnol., 1, 187-196 (1984).
15. Knazek, R. A.: Federation Proceed., 33, 1979-1981 (1974).