Protection from acetaminophen-induced liver damage by the synergistic action of low doses of the poly(ADP-ribose) polymerase-inhibitor nicotinamide and the antioxidant N-acetylcysteine or the amino acid L-methionine

General Pharmacology

Volumn 28, Issue 2, 1997, Pages 257-263

  Kroger H ^a   Dietrich, A ^a   Ohde, M ^a   Lange, R ^b   Ehrlich, W ^c   Kurpisz, M ^d  

^a Deutches Rheumaforschungszentrum B   (Germany)

^b MARTIN LUTHER KRANKENHAUS   (Germany)

^c ROBERT KOCH INSTITUTE   (Germany)

^d INSTITUTE OF HUMAN GENETICS   (Poland)

Author keywords

acetaminophen; hepatotoxicity; methionine; N acetylcysteine; nicotinamide

Indexed keywords

ACETYLCYSTEINE; ALANINE AMINOTRANSFERASE; ANALGESIC AGENT; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; METHIONINE; NICOTINAMIDE; PARACETAMOL; POLY (ADP RIBOSE) POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DRUG POTENTIATION; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER INJURY; LIVER PROTECTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ACETAMINOPHEN; ACETYLCYSTEINE; ALANINE TRANSAMINASE; ANALGESICS, NON-NARCOTIC; ANIMALS; ANTIOXIDANTS; ASPARTATE AMINOTRANSFERASES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; HEPATITIS, TOXIC; MALE; METHIONINE; MICE; MICE, INBRED STRAINS; NIACINAMIDE; POLY(ADP-RIBOSE) POLYMERASES;

EID: 0342460651     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-3623(96)00181-4     Document Type: Article

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