Use of pH gradients in continuous-flow systems and multivariate regression techniques applied to the determination of methionine and cysteine in pharmaceuticals

Analytica Chimica Acta

Volumn 348, Issue 1-3, 1997, Pages 151-159

  Blasco, F ^a   Medina Hernandez M J ^a   Sagrado, S ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Cysteine; Flow injection; Methionine; Multicomponent analysis; Partial least squares regression; pH gradients; Pharmaceuticals

Indexed keywords

CYSTEINE; METHIONINE;

CALIBRATION; CONFERENCE PAPER; DRUG DETERMINATION; DRUG MIXTURE; FLOW INJECTION ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INFORMATION PROCESSING; MULTIVARIATE ANALYSIS; PH; PRIORITY JOURNAL; SPECTROPHOTOMETRY;

EID: 0342437550     PISSN: 00032670     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-2670(97)00063-9     Document Type: Conference Paper

References (13)

1. J.E.F. Reynolds, Martindale - The Extra Pharmacopoeia, 13th ed, The Pharmaceutical Press, London, 1993.
2. P.M. Hardy, Chemistry and Biochemistry of the Amino Acids, G.C. Barrett (Ed.), Chapman and Hall, London, 1985.
3. M. Roth, Anal. Chem., 43 (1971) 880.
4. M.C. García Alvarez-Coque, M.J. Medina-Hernández, R.M. Villanueva Camañas and C. Mongay Fernández, Anal. Biochem., 180 (1989) 172.
5. G. Sarwar, H.G. Botting and R.W. Peace, J. Assoc. Off. Anal. Chem., 71 (1988) 1172.
6. K. Schmeer, M. Khalifa, J. Csaszar, G. Farkas, E. Bayer and I.M. Perl, J. Chromatogr. A, 691 (1995) 285.
7. J.G. Hoogerheide and M.C. Campbell, Anal. Biochem., 201 (1992) 146.
8. A. Giannousios and C. Papadopoulos, Analyst, 121 (1996) 413.
9. J. Saurina and S. Hernández-Cassou, Analyst, 120 (1995) 305.
10. R. Leardi, J. Chemom., 8 (1994) 65.
11. S. Khim Heang and W. Haerdi, Int. J. Environ. Anal. Chem., 15 (1983) 309.
12. I. Ruisánchez, A. Rius, M.S. Larrechi, M.P. Callao and F.X. Rius, Chemom. Intell. Lab. Systems, 24 (1994) 55.
13. United States Pharmacopeia XIX, USP Convention Inc. Rockville, Md., 1975.