Extended release of adenovirus from polymer microspheres: Potential use in gene therapy for brain tumors

Advanced Drug Delivery Reviews

Volumn 27, Issue 1, 1997, Pages 59-66

  Beer, Steven J ^a   Hilfinger, John M ^b   Davidson, Beverly L ^a  

^a UNIVERSITY OF IOWA   (United States)

^b TSRL INC   (United States)

Author keywords

Adenovirus; Cancer; Drug delivery; Gene therapy; Gene transfer; Polymer encapsulation; Thymidine kinase

Indexed keywords

BIODEGRADATION; BRAIN; CONTROLLED DRUG DELIVERY; DRUG DOSAGE; EMULSIONS; ENCAPSULATION; ENZYMES; IMMUNOLOGY; ONCOLOGY; ORGANIC POLYMERS; TOXICITY; VIRUSES;

ADENOVIRUS; POLYMER MICROSPHERES;

GENETIC ENGINEERING;

GENE PRODUCT; MICROSPHERE; POLYGLACTIN; POLYMER; THYMIDINE KINASE; VIRUS VECTOR;

ADENOVIRUS; ANIMAL MODEL; BIODEGRADATION; BRAIN TUMOR; CLINICAL TRIAL; CYTOTOXICITY; EMULSION; GENE THERAPY; GENE TRANSFER; GLIOMA; HUMAN; IMMUNE RESPONSE; IMMUNOSTIMULATION; INFLAMMATION; MICROENCAPSULATION; MORBIDITY; MORTALITY; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS; REVIEW; TECHNIQUE; VIRUS INFECTION; VIRUS RECOMBINANT;

EID: 0342378162     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(97)00022-7     Document Type: Review

References (69)

1. A.E. Walker, M. Robins, F.D. Weinfeld, Epidemiology of brain tumors: the national survey of intracranial neoplasms, Neurology 35 (1985) 219-226.
2. V.A. Levin, P.H. Gutin, S. Leibel, Neoplasms of the central nervous system, in: V.T. DeVita, S. Hellman, S.A. Rosenberg (Eds.), Cancer: Principles and Practice of Oncology. J.B. Lippincott Co., Philadelphia, 1993, pp. 1679-1737.
3. P.Z. New, Central nervous system cancer, in: G.R. Weiss (Ed.), Clinical Oncology. Appleton & Lange, Norwalk, CN, 1993, pp. 146-167.
4. G.G. Giles, M.F. Gonzales, Epidemiology of brain tumors and factors in prognosis, in: A.H. Kaye, E.R. Laws, Jr. (Eds.), Brain Tumors. Churchill Livingston, Tokyo, 1995, pp. 47-67.
5. Y. Mao, M. Desmeules, R.M. Semenciw, G. Hill, L. Gaudette, D.T. Wigle, Increasing brain cancer rates in Canada, Can. Med. Assoc. J. 145 (1991) 1583-1591.
6. M. Salcman, H. Scholtz, R.S. Kaplan, S. Kulik, Long-term survival in patients with malignant astrocytoma, Neurosurgery 34 (1994) 213-229.
7. M.S. Mahaley Jr., C. Mettlin, N. Natarajan, E.R. Laws Jr., B.B. Peace, National survey of patterns of care for brain-tumor patients, J. Neurosurg. 71 (1989) 826-836.
8. A. Cohen, B. Modan, Some epidemiologic aspects of neoplastic diseases in Israeli immigrant population. 3, Brain tumors. Cancer 22 (1968) 1323-1328.
9. D.J. Barker, R.O. Weller, J.S. Garfield, Epidemiology of primary tumours of the brain and spinal cord: a regional survey in southern England, J. Neurol. Neurosurg. Psychiatry 39 (1976) 290-296.
10. P. Trouillas, G. Menaud, G. De The, G. Aimard, M. Devic, Epidemiological study of primary tumors of the neuraxis in the Rhone-Alps region. Quantitative data on the etiology and geographical distribution of 1670 tumors [French], Rev. Neurol. (Paris) 131 (1975) 691-708.
11. B.S. Schoenberg, D.G. Schoenberg, B.W. Christine, M.R. Gomez, The epidemiology of primary intracranial neoplasms of childhood, A population study. Mayo Clin. Proc. 51 (1976) 51-56.
12. J.F. Annegers, B.S. Schoenberg, H. Okazaki, L.T. Kurland, Epidemiologic study of primary intracranial neoplasms, Arch. Neurol. 38 (1981) 217-219.
13. S.C. Ohaegbulam, N. Saddeqi, S. Ikerionwu, Intracranial tumors in Enugu, Nigeria. Cancer 46 (1980) 2322-2324.
14. M. Salcman, The morbidity and mortality of brain tumors: a perspective on recent advances in therapy, Neurol. Clin. 3 (1985) 1-29.
15. M. Salcman, Survival in glioblastoma: historical perspective, Neurosurgery 7 (1980) 435-439.
16. F.L. Moolten, J.M. Wells, Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors, J. Natl. Cancer Inst. 82 (1990) 297-300.
17. Z.D. Ezzeddine, R.L. Martuza, D. Platika, M.P. Short, A. Malick, B. Choi, X.O. Breakefield, Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene, New Biol. 3 (1991) 608-614.
18. K.W. Culver, Z. Ram, S. Wallbridge, H. Ishii, E.H. Oldfield, R.M. Blaese, In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors, Science 256 (1992) 1550-1552.
19. E.H. Oldfield, Z. Ram, K.W. Culver, R.M. Blaese, H.L. DeVroom, W.F. Anderson, Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir, Hum. Gene Ther. 4 (1993) 39-69.
20. Z. Ram, K.W. Culver, S. Walbridge, R.M. Blaese, E.H. Oldfield, In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats, Cancer Res. 53 (1993) 83-88.
21. Z. Ram, K.W. Culver, S. Walbridge, R.M. Blaese, E.H. Oldfield, Retroviral-mediated thymidine kinase gene transfer for the treatment of malignant brain tumors. Hum. Gene Ther. 3, 615 (1992) (Abstract).
22. M.P. Short, B.C. Choi, J.K. Lee, A. Malick, X.O. Breakefield, R.L. Martuza, Gene delivery to glioma cells in rat brain by grafting of a retrovirus packaging cell line, J. Neurosci. Res. 27 (1990) 427-439.
23. Y. Takamiya, M.P. Short, F.L. Moolten, C. Fleet, T. Mineta, X.O. Breakefield, R.L. Martuza, An experimental model of retrovirus gene therapy for malignant brain tumors, J. Neurosurg. 79 (1993) 104-110.
24. D.S. Shewach, L.K. Zerbe, T.L. Hughes, B.J. Roessler, X.O. Breakefield, B.L. Davidson, Enhanced cytotoxicity of antiviral drugs mediated by adenovirus directed transfer of the herpes simplex virus thymidine kinase gene in rat glioma cells, Cancer Gene Ther. 1 (1994) 107-112.
25. B.L. Davidson, E.D. Allen, K.F. Kozarsky, J.M. Wilson, B.J. Roessler, A model system for in vivo gene transfer into the central nervous system using an adenoviral vector, Nat. Genet. 3 (1993) 219-223.
26. B.D. Ross, B. Kim, B.L. Davidson, Assessment of ganciclovir toxicity to experimental intracranial gliomas following recombinant adenoviral-mediated transfer of the herpes simplex virus thymidine kinase gene by magnetic resonance imaging and proton magnetic resonance spectroscopy, Clin. Cancer Res. 1 (1995) 651-657.
27. E.J. Boviatsis, M. Chase, M.X. Wei, T. Tamiya, R.K. Hurford Jr., N.W Kowall, R.I. Tepper, X.O. Breakefield, E.A. Chiocca, Gene transfer into experimental brain tumors mediated by adenovirus, herpes simplex virus, and retrovirus vectors, Hum. Gene Ther. 5 (1994) 183-191.
28. D. Barba, J. Hardin, M. Sadelain, F.H. Gage, Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors, Proc. Natl. Acad. Sci. USA 91 (1994) 4348-4352.
29. M.X. Wei, T. Tamiya, M. Chase, E.J. Boviatsis, T.K. Chang, N.W. Kowall, F.H. Hochberg, D.J. Waxman, X.O. Breakefield, E.A. Chiocca, Experimental tumor therapy in mice using the cyclophosphamide-activating cytochrome P450 2B1 gene, Hum. Gene Ther. 5 (1994) 969-978.
30. S.L. Mansour, T. Grodzicker, R. Tjian, An adenovirus vector system used to express polyoma virus tumor antigens, Proc. Natl. Acad. Sci. USA 82 (1985) 1359-1363.
31. E.A. Goebel, B.L. Davidson, J. Zabner, S.M. Graham, J.A. Kern, Adenovirus-mediated gene therapy for head and neck squamous cell carcinomas, Ann. Otol. Rhinol. Laryngol. 105(7) (1996) 562-567.
32. M.J. Perez-Cruet, T.W. Trask, S.H. Chen, J.C. Goodman, S.L. Woo, R.G. Grossman, H.D. Shine, Adenovirus-mediated gene therapy of experimental gliomas, J. Neurosci. Res. 39 (1994) 506-511.
33. S.H. Chen, H.D. Shine, J.C. Goodman, R.G. Grossman, S.L. Woo, Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo, Proc. Natl. Acad. Sci. USA 91 (1994) 3054-3057.
34. P.P. Hung, B.M. Bhat, P.K. Chanda, M. Chengalvala, S.K. Dheer, M.D. Lubeck, B.B. Mason, K.L. Molnar-Kimber, J.E. Morin, R.J. Natuk, A.R. Davis, Adenovirus as the carrier for immunogen genes. Tech. Adv. Vaccine Dev. (1988) 267-277.
35. B.L. Davidson, S.E. Doran, D.S. Shewach, J.M. Latta, J.W. Hartman, B.J. Roessler, Expression of Escherichia coli beta-galactosidase and rat HPRT in the CNS of Macaca mulatta, following adenoviral mediated gene transfer, Exp. Neurol. 125 (1994) 258-267.
36. S. Akli, C. Caillaud, E. Vigne, L.D. Stratford-Perricaudet, M. Perricaudet, M.R. Peschankski, Transfer of a foreign gene into the brain using adenovirus vectors, Nat. Genet. 3 (1993) 224-228.
37. R.C. Mulligan, The basic science of gene therapy, Science 260 (1993) 926-932.
38. R.D. McCoy, B.L. Davidson, B.J. Roessler, G.B. Huffnagle, R.H. Simon, Expression of human interleukin-1 receptor antagonist in mouse lungs using a recombinant adenovirus: effects on vector-induced inflammation, Gene Ther. 2 (1995) 437-442.
39. R.D. McCoy, B.L. Davidson, B.J. Roessler, G.B. Huffnagle, S.L. Janich, T.J. Laing, R.H. Simon, Pulmonary inflammation induced by incomplete or inactivated particles, Hum. Gene Ther. 6 (1995) 1553-1560.
40. D. Barr, J. Tubb, D. Ferguson, A. Scaria, A. Lieber, C. Wilson, J. Perkins, M.A. Kay, Strain related variations in adenovirally mediated transgene expression from mouse hepatocytes in vivo: comparisons between immunocompetent and immunodeficient inbred strains, Gene Ther. 2 (1995) 151-155.
41. A.P. Byrnes, J.E. Rusby, M.J.A. Wood, H.M. Charlton, Adenovirus gene transfer causes inflammation in the brain, Neuroscience 66 (1995) 1015-1024.
42. S. Cohen, T. Yoshioka, M. Lucarelli, L.H. Hwang, R. Langer, Controlled delivery systems for proteins based on poly(lactic/glycolic acid) microspheres, Pharm. Res. 8 (1991) 713-720.
43. R. Gref, Y. Minamitake, M.T. Peracchia, V. Trubetskoy, V. Torchilin, R. Langer, Biodegradable long-circulating polymeric nanospheres, Science 263 (1994) 1600-1603.
44. H. Okada, T. Heya, Y. Ogawa, H. Toguchi, T. Shimamoto, Sustained pharmacological activities in rats following single and repeated administration of once-a-month injectable microspheres of leuprolide acetate, Pharm. Res. 8 (1991) 584-587.
45. K.J. Pekarek, J.S. Jacob, E. Mathiowitz, Double-walled polymer microspheres for controlled drug release, Nature 367 (1994) 258-260.
46. L.M. Sanders, B.A. Kell, G.I. McRae, G.W. Whitehead, Prolonged controlled-release of nafarelin, a luteinizing hormone-releasing hormone analogue, from biodegradable polymeric implants: influence of composition and molecular weight of polymer, J. Pharm. Sci. 75 (1986) 356-360.
47. B.A. Sabel, P. Dominiak, W. Hauser, M.J. During, A. Freese, Extended levodopa release from a subcutaneously implanted polymer matrix in rats, Ann. Neurol. 28 (1990) 714-717.
48. K.D. Judy, A. Olivi, K.G. Buahin, A. Domb, J.I. Epstein, O.M. Colvin, H. Brem, Effectiveness of controlled release of a cyclophosphamide derivative with polymers against rat gliomas, J. Neurosurg. 82 (1995) 481-486.
49. H. Brem, R.J. Tamargo, A. Olivi, M. Pinn, J.D. Weingart, M. Wharam, J.I. Epstein, Biodegradable polymers for controlled delivery of chemotherapy with and without radiation therapy in the monkey brain, J. Neurosurg. 80 (1994) 283-290.
50. K.A. Walter, M.A. Cahan, A. Gur, B. Tyler, J. Hilton, O.M. Colvin, P.C. Burger, A. Domb, H. Brem, Interstitial taxol delivered from a biodegradable polymer implant against experimental malignant glioma, Cancer Res. 54 (1994) 2207-2212.
51. C.G. Pitt, The controlled parenteral delivery of polypeptides and proteins, Int. J. Pharm. 59 (1990) 173-196.
52. J.H. Eldridge, J.K. Staas, J.A. Meulbroek, T.R. Tice, R.M. Gilley, Biodegradable and biocompatible poly(DL-lactide-co-glycolide) microspheres as an adjuvant for staphylococcal enterotoxin B toxoid which enhances the level of toxin-neutralizing antibodies, Infect. Immun. 59 (1991) 2978-2986.
53. J.H. Eldridge, R.M. Gilley, J.K. Staas, Z. Moldoveanu, J.A. Meulbroek, T.R. Tice, Biodegradable microspheres: vaccine delivery system for oral immunization, Curr. Top. Microbiol. Immunol. 146 (1989) 59-66.
54. B.K. Davis, Control of diabetes with polyacrylamide implants containing insulin, Experentia 28 (1972) 348.
55. M.S. Jhon, J.D. Andrade, Water and hydrogels (Review), J. Biomed. Mater. Res. 7 (1973) 509-522.
56. G.M. Zentner, J.R. Cardinal, J. Feijen, S.Z. Song, Progestin permeation through polymer membranes. IV. Mechanism of steroid permeation and functional group contributions to diffusion through hydrogel films, J. Pharm. Sci. 68 (1979) 970-975.
57. R.S. Langer, J. Folkman, Polymers for the sustained release of proteins and other macromolecules, Nature 263 (1976) 797-800.
58. R.S. Langer, J. Folkman, Sustained release of macromolecules from polymers, in: R.J. Kostelnik (Ed.), Midland Macromolecular Monograph. Gordon and Breach, New York, 1978, pp. 175-195.
59. R.S. Langer, W.D. Rhine, D.S.T. Hsieh, R.S. Bawa, Polymers for the sustained release of macromolecules: applications and control of release kinetics, in: R. Baker (Ed.), Controlled Release of Bioactive Materials. Academic Press, New York, 1980, pp. 83-98.
60. M. Brownlee, A. Cerami, A glucose-controlled insulin-delivery system: semisynthetic insulin bound to lectin, Science 206 (1979) 1190-1191.
61. M. Brownlee, A. Cerami, Glycosylated insulin complexed to Concanavalin A. Biochemical basis for a closed-loop insulin delivery system, Diabetes 32 (1983) 499-504.
62. T.W. Redding, A.V. Schally, T.R. Tice, W.E. Meyers, Long-acting delivery systems for peptides: inhibition of rat prostate tumors by controlled release of [D-Trp6]luteinizing hormone-releasing hormone from injectable microcapsules, Proc. Natl. Acad. Sci. USA 81 (1984) 5845-5848.
63. N.S. Mason, C.S. Niles, R.E. Sparks, Hydrolytic degradation of Poly DL-(lactide), Polym. Sci. Technol. 14 (1981) 279-291.
64. G.E. Visscher, M.A. Robison, G.J. Argentieri, Tissue response to biodegradable injectable microcapsules, J. Biomater. Appl. 2 (1987) 118-131.
65. T.R. Tice, D.R. Cowsar, Biodegradable controlled release parenteral systems, Pharmacol. Technol. 8 (1984) 26-31.
66. R.A. Miller, J.M. Brady, D.E. Cutright, Degradation rates of oral resorbable implants (polylactates and polyglycolates): rate modification with changes in PLA/PGA copolymer ratios, J. Biomed. Mater. Res. 11 (1977) 711-719.
67. D.R. Cowsar, T.R. Tice, R.M. Gilley, J.P. English, Poly(lactide-co-glycolide) microcapsules for controlled release of steroids, Methods Enzymol. 112 (1985) 101-116.
68. J.H. Eldridge, J.K. Staas, T.R. Tice, R.M. Gilley, Biodegradable poly(DL-lactide-co-glycolide) microspheres. Res. Immunol. 143 (1992) 557-563.
69. A. Altman, F. Dixon, Immunomodifiers in vaccines. Adv. Vet. Sci. Comp. Med. 33 (1989) 301-343.