Primary antifungal prophylaxis with low-dose intravenous amphotericin B in hematological malignancies. Results of a pilot study

Onkologie

Volumn 23, Issue 2, 2000, Pages 145-150

  Böhme, Angelika ^a   Hoelzer, D ^b  

^a GOETHE UNIVERSITY   (Germany)

^b NONE

Author keywords

Amphotericin B; Antifungal prophylaxis; Fungal infection; Leukemia

Indexed keywords

AMPHOTERICIN B; AMPHOTERICIN B LIPID COMPLEX; ANTIFUNGAL AGENT; CLEMASTINE; CORTICOSTEROID; CREATININE; CYTARABINE; GRANULOCYTE COLONY STIMULATING FACTOR; ITRACONAZOLE; PETHIDINE; PREDNISOLONE;

ADULT; AGED; ARTICLE; ASPERGILLUS; CHILL; CLINICAL ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DOSE RESPONSE; DRUG EFFICACY; DRUG TOLERABILITY; HUMAN; LEUKEMIA; MYCOSIS; NEPHROTOXICITY; NEUTROPENIA; PNEUMONIA; PROPHYLAXIS; RASH;

EID: 0342369562     PISSN: 0378584X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000027086     Document Type: Article

References (32)

1. Bodey GP, Bueltmann B, Duguid W, Gibbs D, Hanak H, Hotchi M, Mall G, Martino P, Meunier F, Milliken S: Fungal infections in cancer patients: An international autopsy survey. Eur J Clin Microbiol Infect Dis 1992;11:99-109.
2. Pfaffenbach B, Donhuijsen K, Pahnke J, Bug R, Adamek RJ, Wegener M, Ricken D: Pilzinfektionen bei hämatologischen Neoplasien. Eine Autopsie-studie an 1053 Patienten. Med Klinik 1994;89: 299-304.
3. Groll AH, Shah PM, Mentzel C, Schneider M, Just-Nübling G, Hübner K: Trends in postmortem epidemiology of invasive fungal infections at a university hospital. J Infect 1996;33:23-32.
4. Rüchel R: Diagnosis of invasive mycoses in severely immunosuppressed patients. Ann Hematol 1993;67: 1-11.
5. Denning DW, Evans EG, Kibbler CC, Richardson MD, Roberts MM, Rogers TR, Warnock DW, Warren RE: Guidelines for the investigation of invasive fungal infections in haematological malignancy and solid organ transplantation. Eur J Clin Microbiol Infect Dis 1997;16:424-436.
6. Viscoli C, Castagnola E, Machetti M: Antifungal treatment in patients with cancer. J Intern Med 1997;242(suppl 740):89-94.
7. Böhme A, Karthaus M: Antifungal prophylaxis in neutropenic patients with hematologic malignancies: Is there a real benefit? Chemother 1999;45:224-232.
8. Ruhnke M, Beyer J: Antimykotische Prophylaxe bei neutropenischen und immunsupprimierten Patienten. Med Klinik 1997;92:28-36.
9. Uzun O, Anaissie EJ: Antifungal prophylaxis in patients with hematologic malignancies: A reappraisal. Blood 1995;86:2063-2072.
10. Karp JE, Burch PA, Merz WG: An approach to intensive antileukemia therapy in patients with previous invasive aspergillosis. Am J Med 1988;85:203-206.
11. Richard C, Romón I, Baro J, Insunza A, Loyola I, Zurbano F, Tapia M, Iriondo A, Conde E, Zubizarreta A: Invasive pulmonary aspergillosis prior to bone marrow transplant in acute leukemia patients does not predict a poor outcome. Bone Marrow Transplant 1993;12:237-241.
12. Clements JS Jr, Peacock JE Jr: Amphotericin B revisited: Reassessment of toxicitv. Am J Med 1990; 88(suppl 5 N):22N-27N.
13. Bodey GP, Anaissie EJ, Elting LS, Estey E, O'Brian S, Kantarjian H: Antifungal prophylaxis during remission induction therapy for acute leukemia. Fluconazole versus intravenous amphotericin B. Cancer 1994;73:2099-2106.
14. Perfect JR, Klotman ME, Gilbert CC, Crawford DD, Rosner GL, Wright KA, Peters WP: Prophylactic intravenous amphotericin B in neutropenic autologous bone marrow transplant recipients. J Infect Dis 1992;165:891-897.
15. Rousey SR, Russler S, Gottlieb M, Ash RC: Low-dose amphotericin B prophylaxis against invasive Aspergillus infections in allogeneic marrow transplantation. Am J Med 1991;91:484-492.
16. Riley DK, Pavia AT, Beatty PG, Petersen FB, Spruance JL, Stokes R, Evans TG: The prophylactic use of low-dose amphotericin B in bone marrow transplant patients. Am J Med 1994;97:509-514.
17. Tollemar J, Ringden O, Andersson S, Sundberg B, Ljungman P, Tyden G: Randomized double-blind study of liposomal amphotericin B (AmBisome) prophylaxis of invasive fungal infections in bone marrow transplant recipients. Bone Marrow Transplant 1993;12:577-582.
18. Ritter J, Ahlke E, Boos J, Jürgens H: Prophylactic use of liposomal amphotericin B (AmBisome) in neutropenic children with hematological malignancies and high risk for invasive fungal infections. Ann Hematol 1995;18(suppl 2):198.
19. Kelsey SM, Goldman KM, McCann S, Newland AC, Scarffe JH, Oppenheim BA, Mufti GJ: Liposomal amphotericin (AmBisome) in the prophylaxis of fungal infections in neutropenic patients: A randomised, double-blind, placebo-controlled study. Bone Marrow Transplant 1999;23:163-168.
20. Böhme A, Just-Nübling G, Bergmann L, Shah PM, Stille W, Hoelzer D: Itraconazole for prophylaxis of systemic mycoses in neutropenic patients with haematological malignancies. J Antimicrob Chemother 1996;38:953-961.
21. Böhme A, Karthaus M, Einsele H, Ruhnke M, Südhoff T, Buchheidt D, Enzensberger R, Szelényi H, Glasmacher A, Just-Nübling G, Gümbel H: Diagnostik systemischer Pilzinfektionen in der Hämatologic. Dtsch Med Wochenschr 1999;124 (suppl 1):24-30.
22. Anderson CM: Sodium chloride treatment of amphotericin B nephrotoxicity. Standard of care? West J Med 1995;162:313-317.
23. Menichetti F, Del Favero A, Martino P, Bucaneve G, Micozzi A, Girmenia C, Barbabietola G, Pagano L, Leoni P, Specchia G, Caiozzo A, Raimondi R, Mandelli F, and the GIMEMA Infection Program: Itraconazole oral solution as prophylaxis for fungal infections in neutropenic patients with hematologic malignancies: A randomized placebo-controlled double-blind multicenter trial. Clin Infect Dis 1999; 28:250-255.
24. Glasmacher A, Molitor E, Hahn C, Bomba K, Ewig S, Leutner C, Wardelmann E, Schmidt-Wolf IG, Mezger J, Marklein G, Sauerbruch T: Antifungal prophylaxis with itraconazole in neutropenic patients with acute leukaemia. Leukemia 1998;12:1338-1343.
25. Bolam S, Myint H: Prophylactic low dose amphotericin B lipid complex (Abelcet) is effective in the prevention of recurrence of fungal pneumonia following myelosuppressive chemotherapy. Blood 1996;88(suppl 1):36b.
26. Winston DJ, Chandrasekar PH, Lazarus HM, Goodman JL, Silber JL, Horowitz H, Shadduck RK, Rosenfeld CS, Ho WG, Islam MZ: Fluconazole prophylaxis of fungal infections in patients with acute leukemia. Results of a randomized placebo-controlled double-blind multicenter trial. Ann Intern Med 1993;118:495-503.
27. Alangaden G, Chandrasekar PH, Bailey E, Khaliq Y: Antifungal prophylaxis with low-dose fluconazole during bone marrow transplantation. Bone Marrow Transplant 1994;14:919-924.
28. Rotstein C, Bow EJ, Laverdiere M, Joannou S, Carr D, Moghaddam N, and The Canadian Fluconazole Prophylaxis Study Group: Randomized placebo-controlled trial of fluconazole prophylaxis for neutropenic cancer patients: Benefit based on purpose and intensity of cytotoxic therapy. Clin Infect Dis 1999;28:331-340.
29. Mayer J, Doubek M, Vorlicek J: Must we really fear toxicity of conventional amphotericin B in oncological patients? Support Care Cancer 1999;7:51-55.
30. Sawaya BP, Briggs JP, Schnermann J: Amphotericin B nephrotoxicity: The adverse consequences of altered membrane properties. J Am Soc Nephrol 1995;6:154-164.
31. Burks LC, Aisner J, Fortner CL, Wiernik PH: Meperidine for the treatment of shaking chills and fever. Arch Intern Med 1980;140:483-484.
32. Pauca AL, Savage RT, Simpson S, Roy RC: Effect of pethidine, fentanyl and prophine on postoperative shivering in man. Acta Anaesthesiol Scand 1984;28: 138-142.