Effects of hydroxylated flavonoids on the ethoxyresorufin O-deethylase and benzo(α)pyrene hydroxylase

Archives of Pharmacal Research

Volumn 19, Issue 6, 1996, Pages 514-519

  Han, Sun Ho ^a   Sheen, Yhun Yhong ^a  

^a Ewha Womans University   (South Korea)

Author keywords

3 methylcholanthrene; Benzo(a)pyrene hydroxylase; Cytochrome P450; Ethoxyresorufin O deethylase; Flavonoid

Indexed keywords

EID: 0342285697     PISSN: 02536269     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02986021     Document Type: Article

References (18)

1. 1 metabolism in human liver microsomes by naturally occuring flavonoids. Cancer Research, 41, 67-72 (1981).
2. Canivenc-Lavier, M. C., Bentejac, M., Miller, M. L., Leclerc, J., Siess, M. H., Latruffe, N. and Suschetet, M. Differential effects of nonhydroxylated flavonoids as inducers of cytochrome P450 IA and IIB isozymes in rat liver. Toxicol. Appl. Pharmacol., 136, 348-53 (1996).
3. Cody, V., Middleform, E., Itaborne, J. B. and Beretz, A., Plants Flavonoids in biology and medicine II : Biochemical cellular and Medicinal Properties. Alan R. Liss, Inc., New York, 1988.
4. Das, N. P., Flavonoids in Biology and Medicine III: structure and activity. National University of Singapore, Singapore, 1989.
5. Denison, M. S., Fisher, J. M. and Whitlock, J. P., The DNA recognition site for the dioxin-Ah receptor complex. J. Biol. Chem., 85, 2528-2532 (1988).
6. Farkas, L., Garbor, M. and Kally, F., Flavonoids and Bioflavonoids:physiology and pharmacology. Akademiai Kiado, Budapast 1986.
7. Foldes, R. L., Hines, R. N., Ho, Kai-Ling., Shen, Mei-Ling, Nagel, K. B. and Bresnic, E., 3-Methylcholanthrene-induced expression of the cytochrome P-450c gene. Archives of Biochemistry and Biophysics, 239, 137-146 (1985).
8. Fujino, T., West, D., Park, S. S. and Gelboin, H. V., Monoclonal antibody-directed phenotyping of cytochrome P-450 dependent aryl hydrocarbon hydroxylase and 7-ethoxycoumarin deethylase in mammalian tissues. J. Biol, Chem., 259, 9044-9050 (1984).
9. Guengerich, F. P., Roles of cytochrome P-450 enzymes in chemical carcinogenesis and cancer chemotherapy. Cancer Research, 48, 2946-2954 (1988).
10. Hapgood, J., Cuthill, S., Denis, M., Poellinger, L. and Gustafsson, J. A., Specific protein-DNA interaction at a xenobiotic-responsive element: Copurification of dioxin receptor and DNA-binding activity. Proc. Natl, Acad. Sci., 86, 60-64 (1989).
11. Hines, R. N., Mathis, J. M. and Jacob, C. S., Identification of multiple regulatory elements on the human cytochrome P450IA1 gene. Carcinogenesis, 9, 1599-1605 (1988).
12. Okey, A. B., Bondy, G. P., Mason, M. E., Nebert, D. W., Forster-Gibson, C. J., Muncan, J. and Dufresne, M. J., Temperature-dependent cytosol-to-nucleus translocation of the Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in continuous cell culture lines. J. Biol, Chem., 255, 11415-11422 (1980).
13. Selway, J. W. T., Plant flavonoids in biology and medicine : Biochemical, pharmacological and structure-activity relationships. Cody, V., Middleton, E. and Harbone, J. B., (Eds.), Alan R. Liss, Inc. New York, pp. 521-536, 1986.
14. Sousa, R. L., and Marietta, M. A., Inhibition of cytochrome P-450 activity in rat liver microsomes by the naturally occurring flavonoid, quercetin. Arch. Biochem. Biophys., 240, 345-357 (1985).
15. Teija O., Sirkku S., Kirsti H., Ari, H. and Kai, O.L., Pretranslational induction of cytochrome P450IA enzymes by β-Naphthoflavone and 3-Methylcholanthrene occurs in different liver zones. Biochem. Pharamcol., 48, 2189-2197 (1994).
16. Tinberlake, C. F. and Henry, B. S. Flavonoids and food. Endeavour, 10, 31-37 (1986).
17. Whitlock, J. P. Jr., The regulation of cytochrome P-450 gene expression. Ann. Rev. Pharmacol. Toxicol., 26, 333-369 (1986).
18. Yao, E. F. and Denison, M. S., DNA sequence determinants for binding of transformed Ah receptor to a dioxin-responsive enhancer. Biochemistry, 31, 5060-5067 (1992).