Effects of ethylcholine mustard azirinium ion (AF64A) on the choline acetyltransferase and nitric oxide synthase activities in mesopontine cholinergic neurons of the rat

Neuroscience

Volumn 82, Issue 3, 1997, Pages 853-866

  Rodriguez M ^a   Mantolan Sarmiento B ^a   Gonzalez Hernandez T ^a  

^a UNIVERSIDAD DE LA LAGUNA   (Spain)

Author keywords

Acetylcholine; Ethylcholine mustard azirinium ion; Laterodorsal tegmental nucleus; Neurotoxins; Nitric oxide; Pedunculopontine tegmental nucleus

Indexed keywords

ACETYLCHOLINESTERASE; ETHYLCHOLINE MUSTARD AZIRIDINIUM; NITRIC OXIDE SYNTHASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHOLINERGIC NERVE CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NERVE CONDUCTION; NONHUMAN; PONS ANGLE; PRIORITY JOURNAL; RAT;

EID: 0342276092     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(97)00293-5     Document Type: Article

References (50)

1. Allen Y. S., Marchbanks R. M. and Sinden J. D. (1988) Non-specific effects of the putative cholinergic neurotoxin ethylcholine mustard aziridinium ion in the rat brain examined by autoradiography, immunocytochemistry and gel electrophoresis. Neurosci. Lett. 95, 69-74.
2. Andrezik J. A. and Beitz A. J. (1985) Reticular formation, central gray and related tegmental nuclei. In The Rat Nervous System (ed. Paxinos G.), Vol. 2, pp. 1-28. Academic, Sydney.
3. Armstrong D. M., Saper C. B., Levey A. I., Wainer B. H. and Terry R. D. (1983) Distribution of cholinergic neurons in the rat brain: demonstrated by the immunocytochemical localization of choline acetyltransferase. J. comp. Neurol. 216, 53-68.
4. Colhoun E. H., Myles L. A. and Rylett R. J. (1986) An attempt to produce cholinergic hypofunction in rat brain using choline mustard aziridinium ion: neurochemical and histological parameters. J. Can. Sci. Neurol. 13, 517-520.
5. Coté P. Y. and Parent A. (1992) Calbindin D-28k and choline acetyltransferase are expressed by different neuronal populations in pedunculopontine nucleus but not in nucleus basalis in the squirrel monkey. Brain Res. 593, 245-252.
6. Dun N. J., Dun S. L. and Förstermann U. (1994) Nitric oxide synthase immunoreactivity in rat pontine medullary neurons. Neuroscience 59, 429-445.
7. Dunbar J. S., Hitchcock K., Latimer M., Rugg E. L. and Ward N. (1991) Excitotoxic lesions of the pedunculopontine tegmental nucleus of the rat. Brain Res. 589, 194-206.
8. Fisher A. and Henin Y. (1980) Choline analogs as potential tools in developing selective animal models of central cholinergic hypofunction. Life Sci. 27, 1615-1634.
9. Fisher A., Mantione C. R., Abraham D. J. and Hanin Y. (1982) Long-term central cholinergic hypofunction induced in mice by ethylcholine aziridinium ion (AF64A) in vivo. J. Pharmac. exp. Ther. 222, 140-154.
10. Futscher B. W., Pieper R. O., Barnes D. M., Hanin Y. and Erickson L. C. (1992) DNA-damaging and transcription-terminating lesions induced by AF64A in vitro. J. Neurochem. 58, 1504-1509.
11. 28k within the cholinergic neurons of the basal forebrain, striatum and brainstem in the rat, monkey, baboon and human. Neuroscience 54, 461-476.
12. Goldenberg G. J., Vanstone C. L. and Bihler Y. (1971) Transport of nitrogen mustard on transport carrier for choline in L5178Y lymphoblasts. Science 172, 1148-1149.
13. Gower A. J., Rousseau D., Jamsin P., Gobert J., Hanin Y. and Wúlfert E. (1989) Behavioural and histological effects of low concentrations of intraventricular AF64A. Eur. J. Pharmac. 166, 271-281.
14. Goldsmith M. and van der Kooy D. (1988) The non-cholinergic descending projections and cholinergic ascending projections from the nucleus tegmenti pedunculopontinus. Brain Res. 455, 386-391.
15. Kang Y. and Kitai S. T. (1990) Electrophysiological properties of pedunculopontine neurons and their postsynaptic responses following stimulation of substantina nigra reticulata. Brain Res. 535, 79-95.
16. Kimura H., McGeer P. L. and McGeer E. C. (1981) The central cholinergic system studied by choline acetyltransferase immunohistochemistry in the cat. J. comp. Neurol. 200, 151-201.
17. Kozlowski M. R. and Arbogast R. E. (1986) Specific toxic effects of ethylcholine nitrogen mustard on cholinergic neurons of the nucleus basalis of Meynert. Brain Res. 372, 45-54.
18. Kuhar M. J., Sethy V. H., Roth R. H. and Aghajanian G. K. (1973) Choline: selective accumulation by central cholinergic neurons. J. Neurochem. 20, 581-593.
19. Kuhar M. J., Dehaven R. N., Yamamura H. I., Rommelspacher H. and Simon J. R. (1975) Further evidence for cholinergic habenulo-interpeduncular neurons: pharmacologic and functional characteristics. Brain Res. 97, 265-275.
20. Leventer S. M., McKeag D., Clancy M., Wülfert E. and Hanin Y. (1985) Intracerebroventricular administration of ethylcholine mustard aziridium ion (AF64A) reduces release of acetylcholine from rat hippocampal slices. Neuropharmacology 24, 453-459.
21. Leventer S. M., Wülfert E. and Hanin Y. (1985) Time course of ethylcholine mustard aziridium ion (AF64A)-induced cholinotoxicity in vivo. Neuropharmacology 26, 361-365.
22. Leonard C. S., Rao S. and Sanchez R. M. (1995) Patterns of neuromodulation and nitric oxide signaling pathway in mesopontine cholinergic neurons. The Neurosciences 7, 319-328.
23. Leonard C. S. and Llinás R. R. (1990) Electrophysiology of mammalian pedunculopontine and laterodorsal tegmental neurons in vitro: implication for the control of REM sleep. In Brain Cholinergic Systems (eds Steriade M. and Biesold D.), pp. 205-223. Oxford University Press, New York.
24. Levy A., Kant G. J., Meyerhoff J. L and Jarrard L. E. (1984) Non-cholinergic neurotoxic effects of AF64A in the substantia nigra. Brain Res. 305, 169-172.
25. Mantione C. R., Fisher A. and Hanin Y. (1981) The AF64A-treated mouse: possible model for central cholinergic hypofunction. Science 213, 579-580.
26. McGurk S. R., Hartgraves S. L., Kelly P. H., Gordon M. N. and Butcher L. L. (1987) Is ethylcholine mustard aziridinium ion a specific cholinergic neurotoxin? Neuroscience 22, 215-224.
27. Meana J. J., Johansson B., Herrera-Marschitz M., O'Connor W. T., Goiny M., Parkinson F. E., Fredholm B. B. and Ungerstedt U. (1992) Effect of the neurotoxin AF64A on intrinsic and extrinsic neuronal systems of rat neostriatum measured by in vivo microdialysis. Brain Res. 596, 65-72.
28. Miller J. W., Gray B. C. and Bardgett M. E. (1992) Effects of selective toxic lesions of cholinergic neurons of the laterodorsal tegmental nucleus on experimental seizures. Brain Res. 579, 161-164.
29. Paxinos G. and Watson C. (1986) The Rat Brain in Stereotaxic Coordinates. 2nd edn, Academic, New York.
30. Potter P. E., Tedford C. E., Kindel G. and Hanin Y. (1989) Inhibition of high-affinity choline transport attenuates both cholinergic and non-cholinergic effects of ethylcholine aziridinium (AF64A). Brain Res. 487, 238-244.
31. Rugg E. L., Dunbar J. S., Latimer M. and Winn P. (1992) Excitotoxic lesions of the pedunculopontine tegmental nucleus of the rat. I. Comparison of the effects of various excitotoxins with particular reference to the loss of immunohistochemically identified cholinergic neurons. Brain Res. 589, 181-193.
32. Rylett B. J. and Colhoun E. H. (1980) Kinetic data on the inhibition of high-affinity choline transport into the rat forebrain synaptosomes by choline-like compounds and nitrogen mustard analogues. J. Neurochem. 34, 713-719.
33. Sandberg K., Hanin I., Fisher A. and Coyle J. T. (1984) Selective cholinergic neurotoxin: AF64A's effects in rat striatum. Brain Res. 293, 49-55.
34. Sandberg K., Schnaar R. L., McKinney M., Hanin I., Fisher A. and Coyle J. T. (1985) AF64A: an active site directed irreversible inhibitor of choline acetyltransferase. J. Neurochem. 44, 439-445.
35. Scarnati E., Proia A., Di Loreto S. and Pacitti C. (1987) The reciprocal electrophysiological influence between the nucleus tegmenti pedunculopontinus and the substantia nigra in normal and decorticated rats. Brain Res. 423, 116-124.
36. Schuman E. M. and Madison D. V. (1994) Nitric oxide and synaptic function. A. Rev. Neurosci. 17, 153-183.
37. Spann B. M. and Grofova I. (1992) Cholinergic and non-cholinergic neurons in the rat pedunculopontine tegmental nucleus. Anat. Embryol. 186, 215-227.
38. Standaert D. G., Saper C. B., Rye D. B. and Wainer B. H. (1986) Colateralization of atriopeptine-like immunoreactivity with choline acetyltransferase- and substantia P-like immunoreactivity in the pedunculopontine nucleus in the rat. Brain Res. 382, 163-168.
39. Stwertka S. A. and Olson G. L. (1986) Neuropathology and amphetamine-induced turning resulting from AF64A injections into the striatum of the rat. Life Sci. 38, 1105-1110.
40. Sugaya K. and McKinney M. (1994) Nitric oxide synthase gene expression in cholinergic neurons in the rat brain examined by combined immunocytochemistry and in situ hybridization histochemistry. Molec. Brain Res. 23, 111-125.
41. Tamer A. El., Corey J., Wülfert E. and Hanin Y. (1992) Reversible cholinergic changes induced by AF64A in rat hippocampus and possible septal compensatory effect. Neuropharmacology 31, 397-402.
42. Valtschanoff J. G., Weinberg R. J., Kharazia V. N., Nakane M. and Schmidt H. H. H. W. (1993) Neurons in rat hippocampus that synthesize nitric oxide. J. comp. Neurol. 331, 111-121.
43. Villani L., Contestabile A., Migani P., Poli A. and Fonnum F. (1986) Ultrastructural and neurochemical effects of the presumed cholinergic toxin AF64A in the rat interpeduncular nucleus. Brain Res. 379, 223-231.
44. Vincent S. R. (1994) Nitric oxide: a radical neurotransmitter in the central nervous system. Prog. Neurobiol. 42, 129-160.
45. Vincent S. R., Satoh K., Armstrong D. M. and Fibiger H. C. (1983) NADPH-diaphorase: a selective histochemical marker for the cholinergic neurons of pontine reticular formation. Neurosci. Lett. 43, 31-36.
46. Wainer L. R. and Mesulam M. M. (1990) Ascending cholinergic pathways in the rat brain. In Brain Cholinergic Systems (eds Steriate M. and D. Biesold D.), pp. 65-199. Oxford University Press, Oxford.
47. Wanaka A., Johnson E. M. and Milbrandt J. (1990) FCF receptor mRNA in the adult CNS by in situ hybridization. Neuron 5, 267-281.
48. Weinberg R., Valtschanoff J. G. and Schmidt H. H. H. W. (1996) The NADPH Diaphorase histochemical stain. In Methods in Nitric Oxide Research (eds Feelisch M. and Stamler S.), pp. 237-248. John Wiley and Sons Ltd, New York.
49. Woolf N. J. and Butcher L. L. (1986) Cholinergic systems in the rat brain: III. Projections from the pontomesencephalic tegmentum to the thalamus, tectum, basal ganglia, and basal forebrain. Brain Res. Bull. 16, 603-637.
50. Woolf N. J., Gould E. and Butcher L. L. (1989) Nerve growth factor is associated with cholinergic neurons of the basal forebrain but not the pontomesencephalon. Neuroscience 30, 143-152.