LYS2 gene and its mutation in Kluyveromyces lactis

Yeast

Volumn 20, Issue 14, 2003, Pages 1171-1175

  Alberti, Adriana ^a   Ferrero, Iliana ^a   Lodi, Tiziana ^a  

^a UNIVERSITY OF PARMA   (Italy)

Author keywords

aminoadipate; Kluyveromyes lactic; LYS2; Lysine; Yeast

Indexed keywords

2 AMINOADIPIC ACID; OXIDOREDUCTASE;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME DEGRADATION; GENE ISOLATION; GENE MUTATION; GENETIC COMPLEMENTATION; KLUYVEROMYCES; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SENSITIVITY ANALYSIS; SEQUENCE HOMOLOGY; SPECIES DIFFERENCE; WILD TYPE;

2-AMINOADIPIC ACID; ALDEHYDE OXIDOREDUCTASES; AMINO ACID SEQUENCE; BASE SEQUENCE; CLONING, MOLECULAR; DNA, FUNGAL; KLUYVEROMYCES; L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE; MOLECULAR SEQUENCE DATA; SEQUENCE ALIGNMENT; TRANSFORMATION, GENETIC;

KLUYVEROMYCES; KLUYVEROMYCES LACTIS; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0242721027     PISSN: 0749503X     EISSN: None     Source Type: Journal    
DOI: 10.1002/yea.1030     Document Type: Article

References (25)

1. Algeri A, Marmiroli N, Viola A, Puglisi PP. 1977. Dependence of cytoplasmic on mitochondrial protein synthesis in K. lactis CBS 2360. II. Genetic studies. Mol Gen Genet 150: 141-145.
2. Altshul SF, Gish W, Miller W, Myers EW, Lipman DJ. 1990. Basic local alignment search tool. J Mol Biol 215: 403-410.
3. Bhattacherjee JK. 1992. Evolution of α-aminoadipate pathway for the synthesis of lysine in fungi. In The Evolution of Metabolic Function, Mortlock RP (eds). CRC Press: Boca Raton, FL; 47-80.
4. + protein to peptide antibiotic synthetase. Yeast 14: 479-484.
5. Bianchi MM, Falcone C, Chen XJ, et al. 1987. Transformation of the yeast Kluyveromyces lactis by new vectors derived from the 1,6 μm circular plasmid pkD1. Curr Genet 12: 185-192.
6. Bleykasten-Grosshans C, Prior C, Potier S. 2001. Cloning and sequence of the LYS2 homologue gene from the osmotolerant yeast Pichia sorbitophila. Yeast 18: 61-67.
7. Bolotin-Fukuhara M, Toffano-Nioche C, Artiguenave F, et al. 2000. Genomic exploration of the hemiascomycetous yeasts: 11. Kluyveromyces lactis. FEBS Lett 487: 66-70.
8. Broquist HP. 1971. Lysine biosynthesis (yeast). Methods Enzymol 17b: 112-129.
9. Casqueiro J, Gutierrez S, Banuelos O, et al. 1998. Characterization of the lys2 gene of Penicillium chrysogenum encoding α-aminoadipic acid reductase. Mol Gen Genet 259: 549-556.
10. Chattoo BB, Sherman F, Azubalis DA, et al. 1979. Selection of lys2 mutants of the yeast Saccharomyces cerevisiae by the utilization of α-aminoadipate. Genetics 93: 51-65.
11. Ehmann DE, Gehring AM, Walsh CT. 1999. Lysine biosynthesis in Saccharomyces cerevisiae: mechanism of α-aminoadipate reductase (Lys2) involves posttranslational phosphopantetheinylation by Lys5. Biochemistry 38: 6171-6177.
12. Fleer R, Chen XJ, Amellal N, et al. 1991a. High-level secretion of correctly processed recombinant human interleukin-1β in Kluyveromyces lactis. Gene 107: 285-295.
13. Fleer R, Yeh P, Amellal N, et al. 1991b. Stable multicopy vectors for high-level secretion of recombinant human serumalbumin in Kluyveromyces lactis. Bio/Technology 9: 968-975.
14. Hijarrubia MJ, Aparicio JF, Casqueiro J, Martin JF. 2001. Characterization of the lys2 gene of Acremonium chrysogenum encoding a functional α-aminoadipate activating and reducing enzyme. Mol Gen Genet 264: 755-762.
15. Ito H, Fukada Y, Murata K, Kimura A. 1983. Transformation of intact yeast cells treated with alkali cations. J Bacteriol 153: 163-168.
16. Mandel JK, Higa S. 1970. Calcium-dependent bacteriophage DNA infection. J Mol Biol 53: 159-162.
17. Morris ME, Jinks-Robertson S. 1991. Nucleotide sequence of the LYS2 gene of Saccharomyces cerevisiae: homology to Bacillus brevis tyrocidine synthetase 1. Gene 98: 141-145.
18. Sagisaka S, Shimura K. 1962. Studies in lysine biosynthesis. IV. Mechanism of activation and reduction of α-aminoadipic acid. J Biochem 52: 155-159.
19. Sambrook J, Russel DW. 2001. Molecular Cloning: A Laboratory Manual, 3rd edn. Cold Spring Harbor Laboratory Press: New York.
20. Sherman F, Fink GR, Hicks JB. 1986. Laboratory Course Manual for Methods in Yeast Genetics. Cold Spring Harbor Laboratory Press: New York.
21. Shina AK, Bhattacherjee JK. 1970. Control of a lysine biosynthesis step by two unlinked genes of Saccharomyces cerevisiae. Biochem Biophys Res Commun 39: 1205-1210.
22. Suvarna K, Seah L, Bhattacherjee V, Bhattacherjee JK. 1998. Molecular analysis of the LYS2 gene of Candida albicans: homology to peptide antibiotic synthetase and the regulation of the α-aminoadipate reductase. Curr Genet 33: 268-275.
23. Van den Berg JA, Van der Laken KJ, Van Ooyen AJJ, et al. 1990. Kluyveromyces as a host for heterologous gene expression: expression and secretion of prochymosin. Bio/Technology 8: 135-139.
24. Wésolowski-Louvel M, Tanguy-Rougeau C, Fukuhara H. 1988. A nuclear gene required for the expression of the linear DNA-associated killer system in the yeast Kluyveromyces lactis. Yeast 4: 71-81.
25. Zaret KS, Sherman F. 1985. α-Aminoadipate as a primary nitrogen source for Saccharomyces cerevisiae mutants. J Bacteriol 162: 579-583.