Identification of bikunin isolated from human urine inhibits calcium oxalate crystal growth and its localization in the kidneys

International Journal of Urology

Volumn 10, Issue 10, 2003, Pages 530-535

  Okuyama, Mitsuhiko ^a   Yamaguchi, Satoshi ^a   Yachiku, Sunao ^a  

^a ASAHIKAWA MEDICAL COLLEGE   (Japan)

Author keywords

Bikunin; Calcium oxalate; Inter alpha trypsin inhibitor

Indexed keywords

CALCIUM OXALATE; INTER ALPHA TRYPSIN INHIBITOR; ULINASTATIN;

AMINO ACID SEQUENCE; ARTICLE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; CRYSTALLIZATION; EPITHELIUM CELL; GLOMERULUS; HENLE LOOP; HUMAN; IMMUNOHISTOCHEMISTRY; KIDNEY COLLECTING TUBULE; KIDNEY DISTAL TUBULE; KIDNEY PROXIMAL TUBULE; MALE; MOLECULAR WEIGHT; MOUSE; NONHUMAN; NORMAL HUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PURIFICATION; URINALYSIS; WESTERN BLOTTING;

ANIMALS; CALCIUM OXALATE; CRYSTALLIZATION; HUMANS; KIDNEY CALCULI; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; TRYPSIN INHIBITOR, KUNITZ SOYBEAN;

EID: 0242720927     PISSN: 09198172     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1442-2042.2003.00677.x     Document Type: Article

References (20)

1. Sørensen S, Hansen K, Bak S, Justesen SJ. An unidentified macromolecular inhibitory constituent of calcium oxalate crystal growth in human urine. Urol. Res. 1990; 18: 373-9.
2. Morikawa M, Yachiku S, Arima S. Isolation and purification of a high molecular weight substance from human urine which inhibits calcium oxalate crystal growth. Int. J. Urol. 1994; 1: 216-22.
3. Höchstrasser K, Reisinger P, Albrecht GJ, Wachter E, Schonberger OL. Isolation of acid-resistant urinary trypsin inhibitors by high performance liquid chromatography and their characterization by N-terminal amino-acid sequence determination. Hoppe Seylers Z Physiol. Chem. 1984; 365: 1123-30.
4. Kaumeyer JF, Polazzi JO, Kotick MP. The mRNA for a proteinase inhibitor related to the HI-30 domain of inter-alpha-trypsin inhibitor also encodes alpha-1-microglobulim (protein HC). Nucl. Acids Res. 1986; 24: 7839-50.
5. Salier JP. Inter-alpha-trypsin inhibitor: emergence of a family within Kunitz-type proteinase inhibitor super-family. Trends Biochem. Sci. 1990; 15: 435-9.
6. Lindqvist A, Bratt T, Altieri M, Kastern W, Akerstrom B. Rat alpha-1-microglobulin: co-expression in liver with the light chain of inter-alpha-trypsin inhibitor. Biochem. Biophys. Acta 1992; 1130: 63-7.
7. Kobayashi H, Shibata K, Fujie M, Sugino D, Terao T. Identification of structural domain in inter-alpha-trypsin inhibitor involved in calcium oxalate crystallization. Kidney Int. 1998; 53: 1727-35.
8. Nakagawa Y, Abram V, Kedzy FJ, Kaiser ET, Coe FL. Purification and characterization of the principal inhibitor of calcium oxalate monohydrate crystal growth in human urine. J. Biol. Chem 1983; 258: 12594-600.
9. Suzuki K, Moriyama M, Nakajima C et al. Isolation and partial characterization of crystal matrix protein as a potent inhibitor of calcium oxalate crystal aggregation: evidence of activation peptide of human prothrombin. Urol. Res. 1994; 22: 45-50.
10. Atmani F, Lacour B, Strecker G, Parvy P, Drueke T, Daudon M. Molecular characteristics of uronic-acid-rich protein, a strong inhibitor of calcium oxalate crystallization in vitro. Biochem. Biophys. Res. Commun. 1993; 31: 1158-65.
11. Medetognon-Benissa J, Tardivel S, Hennequin C, Daudon M, Drueke T, Lacour B. Inhibitory effect of bikunin on calcium oxalate crystallization in vitro and urinary bikunin decrease in renal stone former. Urol. Res. 1999; 27: 69-75.
12. Muramatsu M, Mori S, Matsuzawa Y, Horiguchi Y, Nakanishi Y, Tanaka M. Purification and characterization of urinary trypsin inhibitor, UTI68, from normal human urine, and its cleavage by human uropepsin. J. Biochem. 1980; 88: 1317-29.
13. Kato Y, Kudo M, Shinkawa T et al. Role of O-linked carbohydrate of human urinary trypsin inhibitor on its lysosomal membrane-stabilizing property. Biochem. Biophys. Res. Commun. 1998; 243: 377-83.
14. Ödum L. Immunohistochemical investigation of interalpha-trypsin inhibitor in the urinary tract. APMIS 1989; 97: 357-60.
15. Marlor CW, Delaris KA, Davis G, Muller DK, Greve JM, Tamburini PP. Identification and cloning of human placental bikunin, a novel serine protease inhibitor containing two Kunitz domains. J. Biol. Chem. 1997; 272: 12202-8.
16. Mizushima S, Nii A, Kato K, Uemura A. Gene expression of the two heavy chains and one light chain forming the inter-alpha-trypsin-inhibitor in human tissues. Biol. Pharm. Bull. 1998; 21: 167-9.
17. Moriyama MT, Glenton PA, Khan SR. Expression of inter-alpha inhibitor related proteins in kidneys and urine of hyperoxaluric rats. J. Urol. 2001; 165: 1687-92.
18. Xu Y, Carr PD, Guss JM, Ollis DL. The crystal structure of bikunin from the inter-alpha-trypsin inhibitor complex: a serine protease inhibitor with two Kunitz domain. JMB 1998; 276: 955-66.
19. Atmani F, Glenton PA, Khan SR. Role of inter-alpha-trypsin inhibitor and its related proteins in experimentally induced calcium oxalate urolithiasis. Localization of proteins and expression of bikunin gene in the rat kidney. Urol. Res. 1999; 27: 63-7.
20. Iida S, Peck AB, Byer KJ, Khan SR. Expression of bikunin mRNA in renal epithelial cells after oxalate exposure. J. Urol. 1999; 162: 1480-6.