Immunological effects of interferon-alpha on chronic myelogenous leukemia

Leukemia and Lymphoma

Volumn 44, Issue 12, 2003, Pages 2061-2067

  De Castro, Fabiola Attié ^a   Bonini Palma, Patricia Vianna ^b   Morais, Fabiana Rossetto ^b   Simões, Belinda Pinto ^a   Carvalho, Paulo Villas Boas ^c   Ismael, Sebastião Jose ^a   Lima, Carmen Passos ^c   Voltarelli, Júlio César ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b Reg Blood Ctr of Ribeirao Preto   (Brazil)

^c UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Chronic myelogenous leukemia; Cytokines and NK cytotoxicity; Immunophenotype; Interferon

Indexed keywords

ALPHA INTERFERON; ANTILEUKEMIC AGENT; CD3 ANTIGEN; CD34 ANTIGEN; CD56 ANTIGEN; CD8 ANTIGEN; CELL MARKER; CYTOKINE; FAS LIGAND; GAMMA INTERFERON; HLA DQ ANTIGEN; HLA DR ANTIGEN; INTERLEUKIN 2; INTERLEUKIN 4;

ADULT; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER REGRESSION; CELL ACTIVATION; CELL ACTIVITY; CELL STIMULATION; CHRONIC MYELOID LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOGENETICS; CYTOKINE PRODUCTION; DRUG RESPONSE; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MALE; MONONUCLEAR CELL; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; PRIORITY JOURNAL; STEM CELL;

ADULT; ANTIGENS, CD34; APOPTOSIS; CYTOKINES; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOPHENOTYPING; INTERFERON TYPE II; INTERFERON-ALPHA; INTERLEUKIN-2; INTERLEUKIN-4; KILLER CELLS, NATURAL; LEUKEMIA, MYELOID, CHRONIC; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; REMISSION INDUCTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEM CELLS; TIME FACTORS;

EID: 0242719880     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.1080/1042819031000110973     Document Type: Article

References (35)

1. Sawyers, C.L. (1999) "Chronic myelogenous leukemia", New England Journal of Medicine 340, 1330-1340.
2. Kalidas, M., Kantarjian, H. and Talpaz, M. (2001) "Chronic myelogenous leukemia", Journal of the American Medical Association 286, 895-898.
3. Lee, J.S. (2000) "Chronic myelogenous leukemia", British Journal of Hematology 111, 993-1009.
4. Kolb, J.H., Mittermuller, J., Clemm, C., Ledderooe, G., Brehm, G., Heim, M. and Wilmans, W. (1990) "Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients", Blood 76, 2462-2465.
5. Cullis, J.O., Jiang, Y.Z., Schwarer, A.P., Hughes, T.P., Barrett, A.J. and Goldman, J.M. (1992) "Donor leukocyte infusions for chronic myeloid leukemia in relapse after allogeneic bone marrow transplantation", Blood 79, 1379-1381.
6. Silla, L.M., Pincus, S.M., Locker, J.D. and Glover, J. (1995) "Generation of activated natural killer (A-NK) cells in patients with chronic myelogenous leukemia and their role in the in vitro disappearance of BCR-ABL positive targets", British Journal of Haematology 93, 375-385.
7. Jiang, Y.Z., Barrett, A.J., Goldman, J.M. and Mavroudis, D.A. (1997) "Association of natural killer cell immune recovery with a graft-versus-leukemia effect independent of graft-versus-host disease following allogeneic bone marrow transplantation", Annals of Hematology 14, 1-6.
8. Kantarjian, H.M., Smith, T.L. and O'Brien, S. (1995) "Prolonged survival following achievement of cytogenetic response with alpha-interferon therapy in chronic myelogenous leukemia", Annals of Internal Medicine 122, 254-261.
9. Silver, R.T., Woolf, S.H., Hehlmann, R., Appelbaum, F.R., Anderson, J., Bennett, C., Goldman, J.M., Guilhot, F., Kantarjian, H.M., Lichtin, A.E., Talpaz, M. and Tura, S. (1999) "An evidence-based analysis of the effect of busulfan, hydroxyurea, interferon and allogeneic bone marrow transplantation in treating the chronic phase of chronic myeloid leukemia: developed for the American Society of Hematology", Blood 94, 1517-1536.
10. Guilhot, F. and Lacotte-Thierry, L. (1998) "Interferon-α: mechanisms of action in chronic myelogenous leukemia in chronic phase", Hematology and Cell Therapy 40, 237-239.
11. Jonasch, E. and Haluska, F.G. (2001) "Interferon in oncological practice: review of interferon biology, clinical applications and toxicities", Oncology 6, 34-55.
12. Guarini, A., Massimo, B., Montefusco, E., Petti, M.C., Zepparoni, A., Vitale, A. and Foa, R. (2001) "Phenotypic and functional characterisation of the host immune compartment of chronic myeloid leukemia patients in complete hematological remission", British Journal of Hematology 113, 136-142.
13. Ravandi, F., Kantarjian, H.M., Talpaz, M., O'brien, S., Faderl, S., Giles, F.J., Thomas, D., Cortes, J., Andreoff, M., Estrov, Z., Rios, M.B. and Albitar, M. (2001) "Expression of apoptosis proteins in chronic myelogenous leukemia: associations and significance", Cancer 91, 1964-1972.
14. Kasimir-Bauer, S., Ottinger, H., Wuttke, M., Stellberg, W., Grosse-Wilde, H., Seeber, S., Scheulen, M.E., "Chronic myelogenous leukemia: effect of interferon-alpha treatment on phagocytic activity and capacity of circulating neutrophils". Leukemia Research, 22, 115-117
15. Pawelec, G., da Silva, P., Max, H., Kalbacher, H., Schmidt, H., Bruserud, O., Zugel, U., Baier, W., Rehbein, A. and Pohla, H. (1995) "Relative roles of natural killer- and T cell-mediated anti-leukemia effects in chronic myelogenous leukemia patients treated with interferon-alpha", Leukemia and Lymphoma 18, 471-478.
16. Boyum, A. (1977) "Isolation of lymphocytes, granulocytes and macrophages", Scandinavian Journal of Immunology (Suppl. 5), 9-15.
17. Chang, L., Gusewitch, A.G., Chritton, D.B.W., Folz, J.C., Lebeck, L.K. and Cannarella, S.L.N. (1993) "Rapid flow cytometric assay for the assessment of natural killer cell activity", Journal of Immunological Methods 166, 45-52.
18. Jung, T., Schauer, U., Heusser, C., Neumann, C. and Rieger, C. (1993) "Detection of intracellular cytokines by flow cytometry", Journal of Immunological Methods 159, 197-207.
19. Aglietta, M., Piacibello, W., Stacchinni, A., Dezza, F., Sanavio, F., Malavasi, F., Infelise, V., Resegotti, L. and Gavosto, F. (1986) "Expression of HLA class II (DR, DQ) determinants by normal and chronic granulocyte/monocyte progenitors", Cancer Research 46, 1783-1787.
20. + cell responses in antitumor immunity", Current Opinion Immunology 42, 588-594.
21. Castro, F.A., Paula-Santos, C.M. and Voltarelli, J.C. (1999) "Stimulation of HLA-DR antigen expression in acute and chronic leukemia", Cancer Research and Therapy Control 10, 93 -99.
22. Bishop, G.A. and Hostager, B.S. (2001) "B lymphocyte activation by contact-mediated interactions with T lymphocytes", Current Opinion in Immunology 13, 278-285.
23. Deininger, M.W.N., Goldman, J.M. and Melo, J.V. (2000) "The molecular biology of chronic myeloid leukemia", Blood 96, 3343-3356.
24. Silla, L.M., Whiteside, T.L. and Ball, E.D. (1995) "The role of natural killer cells in the treatment of chronic myeloid leukemia", Journal of Hematotheraphy 4, 269-279.
25. Abbas, A.K., Murphy, K.M. and Sher, A. (1996) "Functional diversity of helper T lymphocyte", Nature 383, 787-793.
26. Murray, J.S. (1998) "How the MHC selects Th1-Th2 immunity", Immunology Today 19, 157-162.
27. Fuchs, E.J., Bedi, A., Jones, R.J. and Hess, A.D. (1995) "Cytotoxic T cells overcome BCR-ABL-mediated resistance to apoptosis", Cancer Research 55, 238-249.
28. Langlade-Demoyen, P., Abastado, J.P., Even, J., Gouru, G., Leblon, V., Binet, J.L. and Kourilsky, P. (1995) "Cytotoxicity T cell response against 210kDA chimeric protein coded by the BCR-ABL fusion gene in chronic myeloid leukemia", Blood 86, 525-537.
29. Whiteside, T.L., Vujanovic, N.L. and Herberman, R.B. (1998) "Natural killer cells and tumor therapy", Current Topics in Microbiology and Immunology 230, 221-244.
30. Molldrem, J.J., Lee, P.P., Wang, C., Felio, K., Kantarjian, H.M., Champlin, R.E. and Davis, M.M. (2000) "Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia", Nature Medicine 6, 1018-1023.
31. Silver, R.T., Benn, P., Verma, R.S., Coleman, M., Soper, L. and Gutfriend, A. (1990) "Recombinant gamma-interferon has activity in chronic myelogenous leukemia", American Journal of Clinical Oncology 13, 49-54.
32. Reuben, J.M., Lee, B.N., Johnson, H., Fristsche, H., Kantarjian, H.M. and Talpaz, M. (2000) "Restoration of Th1 cytokine synthesis by T cells of patients with chronic myelogenous leukemia in cytogenetic and hematologic remission with interferon-alpha", Clinical Cancer Research 6, 1671-1677.
33. Tsuda, H. and Yamasaki, H. (2000) "Type I and II T cell profiles in chronic myelogenous leukemia", Acta Hematologica 103, 96-101.
34. Fujii, S. (2000) "Role of interferon-alpha and clonally expanded T cells in the immunotherapy of chronic myelogenous leukemia", Leukemia and Lymphoma 38, 21-38.
35. Pawelec, G., Rehbein, A., Schlotz, E. and da Silva, P. (1996) "Cellular immune responses to autologous chronic myelogenous leukemia cells in vitro", Cancer Immunology and Immunotherapy 42,