HPLC investigation of free and bound propofol in human plasma and cerebrospinal fluid

Biomedical Chromatography

Volumn 17, Issue 7, 2003, Pages 447-452

  Dawidowicz, Andrzej L ^a   Kalityński, Rafał ^a  

^a MARIA CURIE SK ODOWSKA UNIVERSITY   (Poland)

Author keywords

Liquid liquid extraction; Propofol anaesthesia; Ultrafiltration; UV and fluorescence detection

Indexed keywords

BLOOD; BRAIN; CEREBROSPINAL FLUID;

ARTERIAL BLOOD; DRUG CONCENTRATION; FLUORESCENCE DETECTION; HUMAN PLASMAS; LIQUID-LIQUID EXTRACTION; PROPOFOL; PROPOFOL ANESTHESIA; PROPOFOL CONCENTRATION; SAMPLE PREPARATION PROCEDURE; UV DETECTION;

ULTRAFILTRATION;

CISATRACURIUM; DIAZEPAM; FENTANYL; PROPOFOL;

ACTIVE TRANSPORT; ADULT; ANESTHESIA; ARTERIAL BLOOD; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BINDING; DRUG BLOOD LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG DISTRIBUTION; DRUG TRANSPORT; ELECTIVE SURGERY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIQUID LIQUID EXTRACTION; MALE; NEUROSURGERY; ULTRAFILTRATION;

EID: 0242693865     PISSN: 02693879     EISSN: None     Source Type: Journal    
DOI: 10.1002/bmc.269     Document Type: Article

References (22)

1. Bowers WF, Fulton S and Thompson J. Ultrafiltration vs equilibrium dialysis for determination of free fraction. Clinical Pharmacokinetics 1984; 9 (Suppl.1): 49-60.
2. Coetzee JF, Glen JB, Winns CA and Boshoff LM. Pharmacokinetic model selection for target controlled infusion of propofol. Assessment of three parameter sets. Anesthesiology 1995; 82: 1328-1345.
3. Dawidowicz AL and Fijałkowska A. Determination of propofol in blood by HPLC. Comparison of the extraction and precipitation methods. Journal of Chromatographic Science 1995; 33: 377-382.
4. Dawidowicz AL, Fornal E and Fijałkowska A. Determining the influence of storage time on the level of propofol in blood samples by means of chromatography. Biomedical Chromatography 2000; 14: 249-255.
5. Dawidowicz AL, Fijałkowska A, Nestorowicz A and Fornal E. The influence of blood sample storage time on the propofol concentration in plasma and solid blood elements. Biomedical Chromatography 2001; 15: 408-412.
6. Dawidowicz AL, Kalityński R, Nestorowicz A and Fijałkowska A. Changes of propofol concentration in cerebrospinal fluid during continuous infusion. Anesthesia and Analgesia 2002; 95: 1282-1284.
7. Dawidowicz AL, Fijałkowska A, Nestorowicz A, Kalityński R and Trojanowski T. Cerebrospinal fluid and blood propofol concentration during total intravenous anaesthesia for neurosurgery. British Journal of Anaesthesiology 2003; 90: 84-86.
8. Dutta S, Matsumoto A, Muramatsu A, Matsumoto M, Fukuoka M and Ebling WF. Steady-state propofol brain:plasma and brain:blood partition coefficients and the effect-site equilibrium paradox. British Journal of Anaesthesia 1998; 81: 422-424.
9. Engdahl O, Abrahams M, Björnsson A et al. Cerebrospinal fluid concentrations of propofol during anaesthesia in humans. British Journal of Anaesthesia 1998; 81: 957-959.
10. Ganong WF. Review of Medical Physiology, 19th edn, Chap. 32. Appleton & Lange: Stamford, CA. 1999.
11. Ghersi-Egea JF and Strazielle N. Brain drug delivery, drug metabolism, and multidrug resistance at the choroid plexus. Microscopic Research Technology 2001; 52: 83-88.
12. Hoag G. Urinanalysis, clinical microscopy and fluids. In Clinical Laboratory Medicine, Tilton RC, Balows A, Hohnadel DC and Reiss RF (eds). Mosby Yearbook: St Louis, MO, 1992; 402-447.
13. Kanto JH. Propofol, the newest induction agent of anaesthesia. International Journal of Clinical Pharmacology Therapy and Toxicology 1988; 26: 41-57.
14. Langley MS and Heel RC. Propofol. A review of its pharmacodynamic and pharmacokinetic properties and use as an intravenous anaesthetic. Drugs 1988; 35: 334-372.
15. Mazoit JX and Samii K. Binding of propofol to blood components: implications for pharmacokinetics and for pharmacodynamics. British Journal of Clinical Pharmacology 1999; 47: 35-42.
16. Mehta AC. Therapeutic monitoring of free (unbound) drug levels: analytical aspects. Trends in Analytical Chemistry 1989; 8: 107-112.
17. Morgan DJ, Campbell GA and Crankshaw DP. Pharmacokinetics of propofol when given by intravenous infusion. British Journal of Clinical Pharmacology 1990; 30: 144-148.
18. Pacifici GM and Viani A. Methods of determining plasma and tissue binding of drugs. Pharmacokinetic consequences. Clinical Pharmacokinetics 1992; 23: 449-68.
19. Pollay M. Cerebrospinal fluid. In The Practice of Neurosurgery, Tindall GT, Cooper PR and Barrow DL (eds). Williams & Wilkins: Baltimore, MD, 1996; 35-44.
20. Prough DS. Perioperative fluid management: the use of crystaloid, collioid and hypertonic solutions. In ASA 1993 Annual Refresher Course Lectures. ASA: Washington, DC. 1993: 223.
21. Schütler J and Ihmsen H. Population pharmacokinetics of propofol: a multicenter study. Anesthesiology, 2000; 92: 727-738.
22. Sebille B, Zini R, Madjar CV, Thuaud N and Tillement JP. Separation procedures used to reveal and follow drug - protein binding. Journal of Chromatographly 1990; 531: 51-77.