Excitatory α1-adrenergic receptors predominate over inhibitory β-receptors in rabbit dorsal detrusor

Journal of Urology

Volumn 170, Issue 6 I, 2003, Pages 2503-2507

  Chou, Eric Chieh Lung ^b   Capello, Seth A ^b   Levin, Robert M ^b   Longhurst, Penelope A ^a  

^a ALBANY COLLEGE OF PHARMACY AND HEALTH SCIENCES   (United States)

^b NONE

Author keywords

Bladder; Norepinephrine; Rabbits; Receptors, adrenergic, alpha 1; Receptors, adrenergic, beta

Indexed keywords

2 [[2 (2,6 DIMETHOXYPHENOXY)ETHYL]AMINOMETHYL] 1,4 BENZODIOXAN; 5 METHYLURAPIDIL; 8 [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] 8 AZASPIRO[4.5]DECANE 7,9 DIONE; ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 1 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; CHLOROETHYLCLONIDINE; NORADRENALIN; PRAZOSIN; RECEPTOR SUBTYPE; ADRENERGIC RECEPTOR ALPHA(1A); ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; DIOXANE DERIVATIVE; PIPERAZINE DERIVATIVE;

ADRENERGIC STIMULATION; ANIMAL TISSUE; ARTICLE; DETRUSOR MUSCLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RABBIT; SMOOTH MUSCLE CONTRACTILITY; ANIMAL; BLADDER; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; IN VITRO STUDY; MALE; MUSCLE CONTRACTION; PHYSIOLOGY; SMOOTH MUSCLE;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; DIOXANES; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NOREPINEPHRINE; PIPERAZINES; PRAZOSIN; RABBITS; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, ADRENERGIC, BETA; URINARY BLADDER;

EID: 0242692434     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ju.0000094184.97133.69     Document Type: Article

References (18)

1. Mellanby, J. and Pratt, C. L. G.: The reactions of the urinary bladder of the cat under conditions of constant pressure. Proc R Soc Lond, 127: 307, 1939
2. Ahlquist, R. P.: A study of the adrenotropic receptors. J Pharmacol Exp Ther, 153: 586, 1948
3. Edvardsen, P. and Setekleiv, J.: Distribution of adrenergic receptors in the urinary bladder of cats, rabbits, and guinea pigs. Acta Pharmacol Toxicol, 26: 437, 1968
4. Levin, R. M. and Wein, A. J.: Distribution and function of adrenergic receptors in the urinary bladder. Mol Pharmacol, 16: 441, 1979
5. Price, D. T., Schwinn, D. A., Lomasney, J. W., Allen, L. F., Caron, M. G. and Lefkowitz, R. J.: Identification, quantification, and localization of mRNA for three distinct alpha, adrenergic receptor subtypes in human prostate. J Urol, 150: 546, 1993
6. 1a-adrenoceptor subtype in the rat, monkey and human urinary bladder and prostate. J Urol, 157: 1032, 1997
7. 1-Adrenergic receptor subtypes in human detrusor. J Urol, 160: 937, 1998
8. Moore, C. K., Levendusky, M. and Longhurst, P. A.: Relationship of mass of obstructed rat bladders and responsiveness to adrenergic stimulation. J Urol, 168: 1621, 2002
9. Arunlakshana, O. and Schild, H. O.: Some quantitative uses of drug antagonists. Br J Pharmacol, 14: 48, 1959
10. Downie, J. W., Dean, D. M., Carro-Ciampi, G. and Awad, S. A.: A difference in sensitivity to alpha-adrenergic agonists exhibited by detrusor and bladder neck of rabbit. Can J Physiol Pharmacol, 53: 525, 1975
11. Kava, M. S., Blue, D. R., Jr., Vimont, R. L., Clarke, D. E. and Ford, A. P.: Alpha 1L-adrenoceptor mediation of smooth muscle contraction in rabbit bladder neck: a model for lower urinary tract tissues of man. Br J Pharmacol, 123: 1359, 1998
12. Leonardi, A., Hieble, J. P., Guarneri, L., Naselsky, D. P., Poggesi, E., Sironi, G. et al: Pharmacological characterization of the uroselective alpha-1 antagonist Rec 15/2739 (SB 216469): role of the alpha-1L adrenoceptor in tissue selectivity, part I. J Pharmacol Exp Ther, 281: 1272, 1997
13. Goepel, C., Wittmann, A., Rubben, H. and Michel, M. C.: Comparison of adrenoceptor subtype expression in porcine and human bladder and prostate. Urol Res, 25: 199, 1997
14. Hampel, C., Dolber, P. C., Smith, M. P., Savic, S. L., Thüroff, J. W., Thor, K. B. et al: Modulation of bladder α1-adrenergic receptor subtype expression by bladder outlet obstruction. J Urol, 167: 1513, 2002
15. Longhurst, P. A.: In vitro rat bladder function after neonatal estrogenization. J Urol, 168: 2695, 2002
16. Bezuijen, M. W. F., Levendusky, M. C. and Longhurst, P. A.: Functional response of bladder strips from streptozotocin-diabetic rats depends on bladder mass. J Urol, 169: 2397, 2003
17. Rohner, T. J., Hannigan, J. D. and Sanford, E. J.: Altered in vitro adrenergic responses of dog detrusor muscle after chronic bladder outlet obstruction. Urology, 11: 357, 1978
18. Perlberg, S. and Caine, M.: Adrenergic response of bladder muscle in prostatic obstruction. Its relation to detrusor instability. Urology, 20: 524, 1982