Absorption, Tissue Distribution, Excretion, and Metabolism of Clothianidin in Rats

Journal of Agricultural and Food Chemistry

Volumn 51, Issue 24, 2003, Pages 7066-7072

  Yokota, Tokunori ^a   Mikata, Kazuki ^a   Nagasaki, Hiromi ^a   Ohta, Kazunari ^a  

^a SUMITOMO CHEMICAL CO LTD   (Japan)

Author keywords

Absorption; Clothianidin; Distribution; Excretion; Metabolism; Neonicotinoid; Rat

Indexed keywords

1 METHYL 4 NITROGUANIDINE; 2 (METHYLTHIO)THIAZOLE 5 CARBOXYLIC ACID; CARBON; CARBON 14; CARBOXYLIC ACID DERIVATIVE; CLOTHIANIDIN; GUANIDINE DERIVATIVE; INSECTICIDE; N (2 CHLOROTHIAZOL 5 YLMETHYL) N' NITROGUANIDINE; NITROGEN; NITROGUANIDINE; NITROIMINOCLOTHIANIDIN; THIAZOLE DERIVATIVE; THIAZOLYLCLOTHIANIDIN; THIAZOLYLMETHYL DERIVATIVE; UNCLASSIFIED DRUG;

ABSORPTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CHEMICAL ANALYSIS; CHEMICAL BOND; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DEMETHYLATION; DISSOCIATION; DOSE RESPONSE; EXCRETION; FECES; FEMALE; HALF LIFE TIME; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOTOPE LABELING; KIDNEY; KINETICS; LIVER LEVEL; MALE; METABOLISM; NONHUMAN; OXIDATION; RADIOACTIVITY; RAT; SEX DIFFERENCE; THIN LAYER CHROMATOGRAPHY; TISSUE DISTRIBUTION; URINARY EXCRETION;

ANIMALS; CARBON RADIOISOTOPES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, THIN LAYER; FECES; FEMALE; GUANIDINES; INSECTICIDES; MALE; RATS; RATS, WISTAR; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 0242691799     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf034760f     Document Type: Article

References (10)

1. Kando, Y.; Uneme. H.; Minamida, I. Novel intermediates for preparing guanidine derivatives, their preparation and use. EP Patent 452782, 1991.
2. Uneme, H.; Iwanaga, K.; Higuchi, N,; Kando, Y.; Okauchi, T.; Akayama, A. ; Minamida, I. Synthesis and insecticidal activity of nitroguanidine derivatives. Pestic. Sci. 1999, 55, 202-205.
3. Mizuta, K. Summary of toxicity studies with clothianidin. J. Pestic. Sci. 2003, 28, 167-173.
4. Ohkawara, Y.; Akayama, A.; Matsuda, K.; Andersch, W. Clothianidin: a novel broad-spectrum neonicotinoid insecticide. Proc. Brighton Crop Prot. Conf. - Pest Dis. 1 2002, 51-58.
5. Schwarz, M.; Christie, D.: Andersch, W.; Kemper, K. Control of com rootworms (Diabrotica spp.) and of secondary pest of com (Zea mays) using seed treatment of clothianidin. Proc. Brighton Crop Prot. Conf. - Pest Dis. 1 2002, 59-64.
6. Roberts, T. R., Hutson, D. H., Eds. Metabolic Pathways of Agrochemicals. Part 2. Insecticides and Fungicides; The Royal Society of Chemistry: Cambridge, U.K., 1999; pp 105-125.
7. Nauen. R.; Bretschneider, T. New modes of action of insecticides. Pestic. Outlook 2002, 13, 241-245.
8. Matsuda, K.; Buckingham, S. D.; Kleier, D.; Rauh, J. J.; Grauso, M.; Sattelle, D. B. Neonicotinoids: insecticides acting on insect nicotinic acetylcholine receptors. Trends Pharmacol. Sci. 2001, 22, 573-580.
9. Tomizawa, M.; Lee, D. L.; Casida, J. E. Neonicotinoid insecticides: Molecular features conferring selectivity for insect versus mammalian nicotinic receptors. J. Agric. Food Chem. 2000, 48, 6016-6024.
10. Gibson, G. G.; Skett, P. Introduction to Drug Metabolism, 2nd ed.; Blackie Academic and Professional: Glasgow, Scotland, 1994; pp 20-22.