Chronic lymphocytic leukemia presenting in association with aplastic anemia

American Journal of Hematology

Volumn 71, Issue 4, 2002, Pages 323-327

  Zonder, Jeffrey A ^a,c   Keating, Michael ^b   Schiffer, Charles A ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c KARMANOS CANCER INSTITUTE   (United States)

Author keywords

Aplastic anemia; Chronic lymphocytic leukemia; Cyclosporine

Indexed keywords

AMINOCAPROIC ACID; AZATHIOPRINE; CHLORAMBUCIL; CYCLOSPORIN A; GRANULOCYTE COLONY STIMULATING FACTOR; PREDNISONE; THYMOCYTE ANTIBODY;

AGED; ANAMNESIS; APLASTIC ANEMIA; ARTICLE; BONE MARROW APLASIA; BONE MARROW BIOPSY; BONE MARROW HYPOPLASIA; CASE REPORT; CELLULAR IMMUNITY; CHOLANGITIS; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL EXAMINATION; CLINICAL FEATURE; DIAGNOSTIC APPROACH ROUTE; DISEASE ASSOCIATION; FEMALE; HUMAN; HUMORAL IMMUNITY; LYMPHOCYTOSIS; PANCYTOPENIA; PHYSICAL EXAMINATION; PRIORITY JOURNAL; SHOCK;

ADRENAL CORTEX HORMONES; AGED; ANEMIA, APLASTIC; ANTINEOPLASTIC AGENTS; BIOPSY; BONE MARROW; CYCLOSPORINE; FATAL OUTCOME; FEMALE; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC;

EID: 0242684755     PISSN: 03618609     EISSN: None     Source Type: Journal    
DOI: 10.1002/ajh.10226     Document Type: Article

References (26)

1. Diehl LF, Ketchum LH. Autoimmune disease and chronic lymphocytic leukemia: Autoimmune hemolytic anemia, pure red cell aplasia, and autoimmune thrombocytopenia. Semin Oncol 1998(Feb);25(1):80-97.
2. nd Edition, Revised and Expanded. New York: Marcel Dekker, Inc.; 2001.
3. Tura S, Finelli C, Bandini G, Cavo M, Gobbi M. Cyclosporin A in the treatment of CLL associated PRCA and bone marrow hypoplasia. Nouv Rev Fr Hematol 1988;30(5-6):479-481.
4. Singal R, Winfield DA, Greaves M: Bone marrow aplasia in B cell chronic lymphocytic leukaemia: Successful treatment with antithymocyte globulin. J Clin Pathol 1991(Nov);44(11):945-946.
5. Duhrsen U, Augener W, Zwingers T, Brittinger G. Spectrum and frequency of autoimmune derangements in lymphoproliferative disorders: Analysis of 637 cases and comparison with myeloproliferative diseases. Br J Haematol 1987(Oct);67(2):235-239.
6. Pritsch O, Maloum K, Dighiero G. Basic biology of autoimmune phenomena in chronic lymphocytic leukemia. Sem Oncol 1998(Feb);25(1):34-41.
7. Borche L, Lim A, Binet JL, Dighiero G. Evidence that chronic lymphocytic leukemia B lymphocytes are frequently committed to production of natural autoantibodies. Blood 1990;76(3):562-569.
8. Peller S, Kaufman S. Decreased CD45RA T cells in B-cell chronic lymphatic leukemia patients: Correlation with disease stage. Blood 1991;78(6):1569-1573.
9. Ammus SS, Yunis AA. Acquired pure red cell aplasia. Am J Hematol 1987;24:311-326.
10. + tumor cells in B chronic lymphocytic leukemia. Blood 1998;91(11):4273-4281.
11. Maciejewski JP, Hibbs JR, Anderson S, Katevas P, Young NS. Bone marrow and peripheral blood lymphocyte phenotype in patients with bone marrow failure. Exp Hematol 1994;22(11):1102-1110.
12. Noumbos NC, Gascon P, Djeu J, Trost SR, Young NS. Circulating activated suppressor T lymphocytes in aplastic anemia. New Engl J Med 1985;312(5):257-265.
13. Mangan KF, Chikkappa G, Farle P. T gamma (T8) cells suppress growth of erythroid colony forming units in vitro in the pure red cell aplasia of B-cell chronic lymphocytic leukemia. J Clin Invest 1982;70:1148.
14. Young NS, Maciejewski J. The pathophysiology of acquired aplastic anemia. New Engl J Med 1997(May);336(19):1365-1372.
15. Nisticò A, Young NS. Gamma-interferon gene expression in the bone marrow of patients with aplastic anemia. Ann Intern Med 1994;120:463-469.
16. Rawstron AC, Green MJ, Kuzmicki A, Kennedy B, Fenton JAL, Evans PAS, O'Connor SJM, Richards SJ, Morgan GJ, Jack AS, Hillmen P. Monoclonal B-lymphocytes with the characteristics of "indolent" chronic lymphocytic leukemia are present in 3.5% of adults with normal blood counts. Blood 2002(July);100(2):635-639.
17. Weide R, Lyttelton WR, Samson D, Gorg C, Koppler H, Pfluger KH, Havemann K. Sustained trilineage response in a patient with ALG-resistant severe aplastic anaemia after treatment with G-CSF, erythropoietin and cyclosporin A: Association of recovery with marketed elevation of serum alkaline phosphatase. Br J Haematol 1993(Nov);85(3):608-610.
18. Keisu M, Öst Å. Diagnoses in patients with severe pancytopenia suspected of having aplastic anemia. Eur J Haematol 1990;45:11-14.
19. Marsh J, Schrezenmeier H, Marin P, Ilhan O, Ljungman P, McCann S, Socie G, Tichelli A, Passweg J, Hows J, Raghavachar A, Locasciulli A, Bacigalupo A. Prospective randomized multicenter study comparing cyclosporin alone versus the combination of antithymocyte globulin and cyclosporin for treatment of patients with nonsevere aplastic anemia: A report from the European Blood and Marrow Transplant (EBMT) Severe Aplastic Anaemia Working Party. Blood 1999(Apr 1);93(7):2191-2195.
20. Bitencourt MA, Medeiros CR, Zanis-Neto J, Andrade RJ, Ogasawara VS, Freidrich VL, Bonim CMS, Ribeiro RC, Pasquini R. Prednisone and cyclosporine for severe aplastic anemia: 101 Cases treated at a single institution. Blood 1995;86(10);476a (suppl.).
21. Gluckman E, Esperou-Bordeau H, Baruchel A, Boogaerts M, Briere J, Donadio D, Leverger G, Leporrier M, Reiffers J, Janvier M. Multicenter randomized study comparing cyclosporine-A alone and antithymocyte globulin with prednisone for treatment of severe aplastic anemia. Blood 1992(May);79(10):2540-2546.
22. Champlin R, Ho W, Gale RP. Antithymocyte globulin treatment in patients with aplastic anemia. New Engl J Med 1983;308(3):113-118.
23. Doney K, Pepe M, Storb R, Bryant E, Anasetti C, Applebaum FR, Buckner CD, Sanders J, Singer J, Sullivan K, Weiden P, Hansen JA. Immunosuppressive therapy of aplastic anemia: Results of a prospective, randomized trial of antithymocyte globulin (ATG) methylprednisolone, and oxymetholone to ATG, very high-dose methylprednisolone and oxymetholone. Blood 1992(May);79(10):2566-2571.
24. Frickhofen N, Kaltwasser JP, Schrezenmeier H, Raghavachar A, Vogt HG, Herrmann F, Freund M, Meusers P, Salama A, Heimpel H. Treatment of aplastic anemia with antilymphocyte globulin and methylprednisolone with or without cyclosporine. New Engl J Med 1991(May);324(19):1297-1360.
25. Bacigalupo A, Broccia G, Corda G, Arcese W, Carotenuto M, Gallamini A, Locatelli F, Mori PG, Saracco P, Todeschini G, Coser P, Iacopino P, van Lint MT, Gluckman E. Antilymphocyte globulin, cyclosporin and granulocyte colony-stimulating factor in patients with acquired severe aplastic anemia (SAA): A pilot study of the EBMT SAA working party. Blood 1995(March);85(5):1348-1353.
26. Rosenfeld S, Kimball J, Vining D, Young NS. Intensive immunosuppression with antithymocyte globulin and cyclosporine as treatment for severe acquired aplastic anemia. Blood 1995(June);85(11):3058-3065.