Impaired TCR-Mediated Induction of Ki67 by Naive CD4+ T Cells is only Occasionally Corrected by Exogenous IL-2 in HIV-1 Infection

Journal of Immunology

Volumn 171, Issue 10, 2003, Pages 5208-5214

  Sieg, Scott F ^a,b   Bazdar, Douglas A ^a   Lederman, Michael M ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 2 RECEPTOR; KI 67 ANTIGEN; L SELECTIN; RECEPTOR ANTIBODY; RECOMBINANT INTERLEUKIN 2; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ANTIBODY; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ARTICLE; CELL CYCLE; CONTROLLED STUDY; DRUG SENSITIVITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE DEFICIENCY; IMMUNOMODULATION; LYMPHOCYTE FUNCTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION; VACCINE PRODUCTION;

EID: 0242663911     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.10.5208     Document Type: Article

References (46)

1. Kaech, S. M., E. J. Wherry, and R. Ahmed. 2002. Effector and memory T-cell differentiation: implications for vaccine development. Nat. Rev. Immunol. 2:251.
2. Sallusto, F., D. Lenig, R. Forster, M. Lipp, and A. Lanzavecchia. 1999. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401:708.
3. Rabin, R. L., M. Roederer, Y. Maldonado, A. Petru, and L. A. Herzenberg. 1995. Altered representation of naive and memory CD8 T cell subsets in HIV-infected children. J. Clin. Invest. 95:2054.
4. Roederer, M., J. G. Dubs, M. T. Anderson, P. A. Raju, and L. A. Herzenberg. 1995. CD8 naive T cell counts decrease progressively in HIV-infected adults. J. Clin. Invest. 95:2061.
5. McCune, J. M., R. Loftus, D. K. Schmidt, P. Carroll, D. Webster, L. B. Swor-Yim, I. R. Francis, B. H. Gross, and R. M. Grant. 1998. High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection. J. Clin. Invest. 101:2301.
6. + cells in late stages of HIV infection is related to increased risk of death: evidence from a cohort of 347 HIV-infected individuals. AIDS 11:1479.
7. + count in HIV-1-infected patients at time of initiation of highly active antiretroviral therapy is strongly associated with the level of immunological recovery. Scand. J. Infect. Dis. 34:45.
8. Valdez, H., K. Y. Smith, A. Landay, E. Connick, D. R. Kuritzkes, H. Kessler, L. Fox, J. Spritzler, J. Roe, M. B. Lederman, et al. 2000. Response to immunization with recall and neoantigens after prolonged administration of an HIV-1 protease inhibitor-containing regimen: AIDS Clinical Trials Group 375 team. AIDS 14:11.
9. + cell numbers and clinical staging. J. Clin. Invest. 84:1892.
10. Lane, H. C., J. M. Depper, W. C. Greene, G. Whalen, T. A. Waldmann, and A. S. Fauci. 1985. Qualitative analysis of immune function in patients with the acquired immunodeficiency syndrome: evidence for a selective defect in soluble antigen recognition. N. Engl. J. Med. 313:79.
11. + T helper cell depletion occurs. J. Clin. Invest. 82:1908.
12. Cayota, A., F. Vuillier, D. Scott-Algara, V. Feuillie, and G. Dighiero. 1992. Impaired proliferative capacity and abnormal cytokine profile of naive and memory CD4 T cells from HIV-seropositive patients. Clin. Exp. Immunol. 88:478.
13. Frank, D. A., M. J. Robertson, A. Bonni, J. Ritz, and M. E. Greenberg. 1995. Interleukin 2 signaling involves the phosphorylation of Stat proteins. Proc. Natl. Acad. Sci. USA 92:7779.
14. Moriggl, R., D. J. Topham, S. Teglund, V. Sexl, C. McKay, D. Wang, A. Hoffmeyer, J. van Deursen, M. Y. Sangster, K. D. Bunting, G. C. Grosveld, and J. N. Ihle. 1999. Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity 10:249.
15. Hatakeyama, M., H. Mori, T. Doi, and T. Taniguchi. 1989. A restricted cytoplasmic region of IL-2 receptor β chain is essential for growth signal transduction but not for ligand binding and internalization. Cell 59:837.
16. Johnston, J. A., M. Kawamura, R. A. Kirken, Y. Q. Chen, T. B. Blake, K. Shibuya, J. R. Ortaldo, D. W. McVicar, and J. J. O'Shea. 1994. Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2. Nature 370:151.
17. Takeshita, T., H. Asao, K. Ohtani, N. Ishii, S. Kumaki, N. Tanaka, H. Munakata, M. Nakamura, and K. Sugamura. 1992. Cloning of the γ chain of the human IL-2 receptor. Science 257:379.
18. Liu, K. D., S. L. Gaffen, M. A. Goldsmith, and W. C. Greene. 1997. Janus kinases in interleukin-2-mediated signaling: JAKI and JAK3 are differentially regulated by tyrosine phosphorylation. Curr. Biol. 7:817.
19. Zhu, M. H., J. A. Berry, S. M. Russell, and W. J. Leonard. 1998. Delineation of the regions of interleukin-2 (IL-2) receptor β chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to IL-2Rβ. J. Biol. Chem. 273:10719.
20. Sieg, S. F., D. A. Bazdar, C. V. Harding, and M. M. Lederman. 2001. Differential expression of interleukin-2 and γ interferon in human immunodeficiency virus disease. J. Virol. 75:9983.
21. + T cells without affecting early activation responses. J. Clin. Invest. 108:757.
22. Sahraoui, Y., A. Ammar, Y. Lunardi-Iskandar, A. Tsapis, E. Spanakis, N. N'Go, M. Allouche, V. G. Bellile, C. Jasmin, and V. Georgoulias. 1992. Abnormal expression of IL-2Rβ (p70)-binding polypeptide on HIV-infected patients' cells. Cell. Immunol. 139:318.
23. Chopra, R. K., N. B. Raj, J. P. Scally, A. D. Donnenberg, W. H. Adler, A. J. Saah, and J. B. Margolick. 1993. Relationship between IL-2 receptor expression and proliferative responses in lymphocytes from HIV-1 seropositive homosexual men. Clin. Exp. Immunol. 91:18.
24. David, D., L. Bani, J. L. Moreau, M. P. Treilhou, T. Nakarai, M. Joussemet, J. Ritz, B. Dupont, G. Pialoux, and J. Theze. 1998. Regulatory dysfunction of the interleukin-2 receptor during HIV infection and the impact of triple combination therapy. Proc. Natl. Acad. Sci. USA 95:11348.
25. + lymphopenia. J. Infect. Dis. 185:1401.
26. Gerdes, J., H. Lemke, H. Baisch, H. H. Wacker, U. Schwab, and H. Stein. 1984. Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J. Immunol. 133:1710.
27. Bruno, S., and Z. Darzynkiewicz. 1992. Cell cycle dependent expression and stability of the nuclear protein detected by Ki-67 antibody in HL-60 cells. Cell Prolif. 25:31.
28. Jacobberger, J. W., R. M. Sramkoski, P. S. Frisa, P. P. Ye, M. A. Gottlieb, D. W. Hedley, T. V. Shankey, B. L. Smith, M. Paniagua, and C. L. Goolsby. 2003. Immunoreactivity of Stat5 phosphorylated on tyrosine as a cell-based measure of Bcr/Abl kinase activity. Cytometry 54A:75.
29. Howard, M., and D. Kaplan. 2002. Applications of enzymatic amplification staining in immunophenotyping hematopoietic cells. Front Biosci. 7:c33.
30. Kaplan, D., and D. Smith. 2000. Enzymatic amplification staining for flow cytometric analysis of cell surface molecules. Cytometry 40:81.
31. Ellery, J. M., and P. J. Nicholls. 2002. Possible mechanism for the α subunit of the interleukin-2 receptor (CD25) to influence interleukin-2 receptor signal transduction. Immunol. Cell Biol. 80:351.
32. Schluter, C., M. Duchrow, C. Wohlenberg, M. H. Becker, G. Key, H. D. Flad, and J. Gerdes. 1993. The cell proliferation-associated antigen of antibody Ki-67: a very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins. J. Cell Biol. 123:513.
33. Stefanova, I., M. W. Saville, C. Peters, F. R. Cleghorn, D. Schwartz, D. J. Venzon, K. J. Weinhold, N. Jack, C. Bartholomew, W. A. Blattner, R. Yarchoan, J. B. Bolen, and I. D. Horak. 1996. HIV infection-induced posttranslational modification of T cell signaling molecules associated with disease progression. J. Clin. Invest. 98:1290.
34. Cayota, A., F. Vuillier, J. Siciliano, and G. Dighiero. 1994. Defective protein tyrosine phosphorylation and altered levels of p59fyn and p56lck in CD4 T cells from HIV-1 infected patients. Int. Immunol. 6:611.
35. Hemmer, B., I. Stefanova, M. Vergelli, R. N. Germain, and R. Martin. 1998. Relationships among TCR ligand potency, thresholds for effector function elicitation, and the quality of early signaling events in human T cells. J. Immunol. 160:5807.
36. + T cells. J. Exp. Med. 186:757.
37. Auphan-Anezin, N., G. Verdeil, and A. M. Schmitt-Verhulst. 2003. Distinct thresholds for CD8 T cell activation lead to functional heterogeneity: CD8 T cell priming can occur independently of cell division. J. Immunol. 170:2442.
38. + T-cell clones. J. Virol. 75:7803.
39. Bovolenta, C., L. Camorali, M. Mauri, S. Ghezzi, S. Nozza, G. Tambussi, A. Lazzarin, and G. Poli. 2001. Expression and activation of a C-terminal truncated isoform of STAT5 (STAT5 Δ) following interleukin 2 administration or AZT monotherapy in HIV-infected individuals. Clin. Immunol. 99:75.
40. Graves, J. D., J. Downward, M. Izquierdo-Pastor, S. Rayter, P. H. Warne, and D. A. Cantrell. 1992. The growth factor IL-2 activates p21ras proteins in normal human T lymphocytes. J. Immunol. 148:2417.
41. 1 and S in CD3-stimulated primary human T cells. Mol. Cell. Biol. 11:2794.
42. Turner, B., U. Rapp, H. App, M. Greene, K. Dobashi, and J. Reed. 1991. Interleukin 2 induces tyrosine phosphorylation and activation of p72-74 Raf-1 kinase in a T-cell line. Proc. Natl. Acad. Sci. USA 88:1227.
43. Augustine, J. A., S. L. Sutor, and R. T. Abraham. 1991. Interleukin 2- and polyomavirus middle T antigen-induced modification of phosphatidylinositol 3-kinase activity in activated T lymphocytes. Mol. Cell. Biol. 11:4431.
44. Remillard, B., R. Petrillo, W. Maslinski, M. Tsudo, T. B. Strom, L. Cantley, and L. Varticovski. 1991. Interleukin-2 receptor regulates activation of phosphatidylinositol 3-kinase. J. Biol. Chem. 266:14167.
45. Merida, I., E. Diez, and G. N. Gaulton. 1991. IL-2 binding activates a tyrosine-phosphorylated phosphatidylinositol-3-kinase. J. Immunol. 147:2202.
46. Lee, I. H., W. P. Li, K. B. Hisert, and L. B. Ivashkiv. 1999. Inhibition of interleukin 2 signaling and signal transducer and activator of transcription (STAT)5 activation during T cell receptor-mediated feedback inhibition of T cell expansion. J. Exp. Med. 190:1263.