A Loss of Function Mutation in WISP3 Derived from Microsatellite Unstable Gastric Carcinoma [11]

Gastroenterology

Volumn 125, Issue 5, 2003, Pages 1563-1564

  Tanaka, Shinji ^a   Sugimachi, Keishi ^a   Maehara, Shin Ichiro ^a   Shimada, Mitsuo ^a   Maehara, Yoshihiko ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; COMPLEMENTARY DNA; GENE PRODUCT; HEPARAN SULFATE; MESSENGER RNA; MONOCLONAL ANTIBODY; PROTEIN WISP3; THROMBOSPONDIN 1; UNCLASSIFIED DRUG;

AUTOSOMAL RECESSIVE DISORDER; CELL LYSATE; CONTROLLED STUDY; CORRELATION ANALYSIS; GENE FUNCTION; GENE MUTATION; GENE SEQUENCE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LETTER; MICROSATELLITE INSTABILITY; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN FAMILY; STOMACH CARCINOMA; STOP CODON; WESTERN BLOTTING;

EID: 0242658593     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gastro.2003.04.013     Document Type: Letter

References (7)

1. Han HJ, Yanagisawa A, Kato Y, Park JG, Nakamura Y. Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer. Cancer Res 1993;53:5087-5089.
2. Thorstensen L, Holm R, Lothe RA, Trope C, Carvalho B, Sobrinho-Simoes M, Seruca R. WNT-inducible signaling pathway protein 3, WISP-3, is mutated in microsatellite unstable gastrointestinal carcinomas but not in endometrial carcinomas. Gastroenterology 2003;124:270-271.
3. Tanaka S, Sugimachi K, Shimada M, Maehara Y, Sugimachi K. Variant WISPs as targets for gastrointestinal carcinomas. Gastroenterology 2002;123:392-393.
4. Tanaka S, Sugimachi K, Saeki H, Kinoshita J, Ohga T, Shimada M, Maehara Y, Sugimachi K. A novel variant of WISP1 lacking a Von Willebrand type C module overexpressed in scirrhous gastric carcinoma. Oncogene 2001;20:5525-5532.
5. Kleer CG, Zhang Y, Pan Q, van Golen KL, Wu ZF, Livant D, Merajver SD. WISP3 is a novel tumor suppressor gene of inflammatory breast cancer. Oncogene 2002;21:3172-3180.
6. Soon LL, Yie TA, Shvarts A, Levine AJ, Su F, Tchou-Wong KM. Overexpression of WISP-1 downregulated motility and invasion of lung cancer cells through inhibition of Rac activation. J Biol Chem 2003 (in press).
7. Hurvitz JR, Suwairi WM, Van Hul W, El-Shanti H, Superti-Furga A. Roudier J, Holderbaum D, Pauli RM, Herd JK, Van Hul EV, Rezai-Delui H, Legius E, Le Merrer M, Al-Alami J, Bahabri SA, Warman ML. Mutations in the CCN gene family member WISP3 cause progressive pseudorheumatoid dysplasia. Nat Genet 1999; 23:94-98.