Neuroprotective effects of early antiretrovirals in vertical HIV infection

Pediatric Neurology

Volumn 29, Issue 3, 2003, Pages 218-221

  Sánchez Ramón, Silvia ^a   Resino, Salvador ^a   Bellón Cano, José M ^a   Ramos, José T ^c   Gurbindo, Dolores ^b   Muñoz Fernández, Angeles ^a,b  

^a Lab of Immuno Molecular Biology   (Spain)

^b HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^c HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

Author keywords

CNS; Development; HIV 1 related encephalopathy; Pediatric AIDS; Survival; Viral load

Indexed keywords

2',3' DIDEOXYADENOSINE; ANTIRETROVIRUS AGENT; ZIDOVUDINE;

ARTICLE; BRAIN DISEASE; CHILD; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DRUG EFFECT; FEMALE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFANT; MAJOR CLINICAL STUDY; MALE; NEUROPROTECTION; PRIORITY JOURNAL; SURVIVAL RATE; SYMPTOM; TREATMENT OUTCOME; VERTICAL TRANSMISSION;

EID: 0242642886     PISSN: 08878994     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-8994(03)00210-8     Document Type: Article

References (15)

1. Price R.W., Yiannoutsos C.T., Clifford D.B., et al. Neurological outcomes in late HIV infection Adverse impact of neurological impairment on survival and protective effect of antiviral therapy . AIDS. 13:1999;1677-1685.
2. Cooper E.R., Hanson C., Diaz C., et al. Encephalopathy and progression of human immunodeficiency virus disease in a cohort of children with perinatally acquired human immunodeficiency virus infection. J Pediatr. 132:1998;808-812.
3. Lobato M.N., Caldwell M.B., Ng P., Oxtoby M.J. Encephalopathy in children with perinatally acquired human immunodeficiency virus infection. J Pediatr. 126:1995;710-715.
4. McArthur J.C., Hoover D.R., Bacellar H., et al. Dementia in AIDS patients Incidence and risk factors. Multicenter AIDS Cohort Study . Neurology. 43:1993;2245-2252.
5. Sacktor N.C., Lyles R.H., Skolasky R.L., et al. Combination antiretroviral therapy improves psychomotor speed performance in HIV-seropositive homosexual men. Multicenter AIDS Cohort Study (MACS). Neurology. 52:1999;1640-1647.
6. McKinney R.E. Jr, Maha M.A., Connor E.M., et al. A multicenter trial of oral zidovudine in children with advanced human immunodeficiency virus disease. N Engl J Med. 324:1991;1018-1025.
7. Raskino C., Pearson D.A., Baker C.J., et al. Neurologic, neurocognitive, and brain growth outcomes in human immunodeficiency virus-infected children receiving different nucleoside antiretroviral regimens. Pediatric AIDS Clinical Trials Group 152 Study Team. Pediatrics. 104:1999;e32.
8. Munoz-Fernandez M.A., Obregon E., Navarro J., et al. Relationship of virologic, immunologic, and clinical parameters in infants with vertically acquired human immunodeficiency virus type 1 infection. Pediatr Res. 40:1996;597-602.
9. 1994 revised guidelines for the performance of CD4+ T-cell determinations in persons with human immunodeficiency virus (HIV) infections. MMWR Recomm Rep. 43:1994;1-21.
10. Nomenclature and research case definitions for neurologic manifestations of human immunodeficiency virus-type 1 (HIV-1) infection. Report of a Working Group of the American Academy of Neurology AIDS Task Force. Neurology. 41:1991;778-785.
11. HIV-infected pregnant women and vertical transmission in Europe since 1986. AIDS. 15:2001;761-770.
12. Tardieu M., Le Chenadec J., Persoz A., Meyer L., Blanche S., Mayaux M.J. HIV-1-related encephalopathy in infants compared with children and adults. French Pediatric HIV Infection Study and the SEROCO Group. Neurology. 54:2000;1089-1095.
13. Butler K.M., Husson R.N., Balis F.M., et al. Dideoxyinosine in children with symptomatic human immunodeficiency virus infection. N Engl J Med. 324:1991;137-144.
14. Pizzo P.A., Eddy J., Falloon J., et al. Effect of continuous intravenous infusion of zidovudine (AZT) in children with symptomatic HIV infection. N Engl J Med. 319:1988;889-896.
15. Sánchez-Ramón S., Bellón J.M., Resino S., et al. Low CD8+ T-cells may trigger CNS spread of HIV-1-activated monocytes in HIV-1-associated progressive encephalopathy in children. Pediatrics. 111:2003;168-175.