Effect of vitamin E on follicular cell proliferation and expression of apoptosis-associated factors in rats with 6-N-propyl-2-thiouracil-induced goitrogenesis

Folia Histochemica et Cytobiologica

Volumn 41, Issue 4, 2003, Pages 213-217

  Öner, Jale ^a   Kükner, Aysel ^b   Öner, Hakan ^a   Ozan, Enver ^b   Yekeler, Hayrettin ^b  

^a AKDENIZ UNIVERSITY   (Turkey)

^b FIRAT UNIVERSITY   (Turkey)

Author keywords

Bax; Bcl 2; Hypothyroidism; PCNA; Rat; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; CYCLINE; LIOTHYRONINE; PROPYLTHIOURACIL; PROTEIN BAX; PROTEIN BCL 2; THYROTROPIN; THYROXINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BLOOD SAMPLING; CELL COUNT; CELL PROLIFERATION; CONTROLLED STUDY; DECAPITATION; DRUG EFFECT; DRUG INDUCED DISEASE; DRUG WITHDRAWAL; EPITHELIUM CELL; GOITER; HYPOTHYROIDISM; IMMUNOHISTOCHEMISTRY; INVOLUTION; MALE; NONHUMAN; QUANTITATIVE ANALYSIS; RAT; THYROID FOLLICLE CELL; THYROID GLAND;

ANIMALIA;

EID: 0242636240     PISSN: 02398508     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Boscoboinik D, Szewczyk A, Hensey C, Azzi A (1991) Inhibition of cell proliferation by α-tocopherol: Role of protein kinase C. J Biol Chem 266: 6188-6194
2. Chausara SS, Kar A (1997) Protective effects of vitamin E against lead-induced deterioration of membrane associated type-I iodothyronine 5′-monodeiodinase (5′D-I) activity in male mice. Toxicology 124: 203-209
3. Cyz W, Joensuu H, Pylkkanen L, Klemi PJ (1994) p53 protein, PCNA staining, and DNA content in follicular neoplasms of the thyroid gland. J Pathol 174: 267-274
4. Haas AL, Boscoboinik D, Mojon DS, Bohnke M, Azzi A (1996) Vitamin E inhibits proliferation of human Tenon's capsule fibroblasts in vitro. Ophthalmic Res 28: 171-175
5. Hagiwara M, Hachiya T, Watanabe M, Usuda N, Iida F, Tamai K, Hidaka H (1990) Assessment of protein kinase C isozymes by enzyme immunoassay and overexpression of type II in thyroid adenocarcinoma. Cancer Res 50: 5515-5519
6. Koga M, Hiromatsu Y, Jimi A, Toda S, Koike N, Nonaka K (1999) Immunohistochemical analysis of Bcl-2, Bax, and Bak expression in thyroid glands from patients with subacute thyroiditis. J Clin Endocrinol Metab 84: 2221-2225
7. Kükner A, Öner J, Öner H, C̃olakoglu N, Özogul C, Ozan E (2001) Light and electron microscopic observations of the rat thyroid following experimental hypothyroidism Firat Tip Dergisi 2: 202-208
8. Machlin LJ (1984) Vitamin E. In: Handbook of Vitamins. Machlin LJ [Ed], New York-Basel, pp 99-145
9. Mano T, Iwase K, Hayashi R, Hayakawa N, Uchimura K, Makino M, Nagata M, Sawai Y, Oda N, Hamada M, Aono T, Nakai A, Nagasaka A, Itoh M (1998) Vitamin E and coenzyme Q concentration in the thyroid tissues of patients with various thyroid disorders. Am J Med Sci 315: 230-232
10. Mesaros-Kanjski E, Kontosic I, Kusici Z, Kaic-Rak A, Dakovic N, KuserJ, Antonic K (1999) Endemic goitre and plasmatic levels of vitamins A and E in the school-children on the island of Krk, Croatia. Coll Antropol 23: 729-736
11. Mutaku JF, Many MC, Colin I, Denef JF, Hovei MF (1998) Antigoitrogenic effect of combined supplementation with dl-α-tocopherol, ascorbic acid and β-carotene and of dl-α-tocopherol alone in the rat. J Endocrinol 156: 551-561
12. Omri B, Pavlovic-Hournac M (1985) Protein kinase C activity in experimentally developed and regressed rat thyroid goitres. Mol Cell Endocrinol 40: 175-180
13. Omri B, Breton MF, Pavlovic-Hournac M (1986) Endogenous substrates of protein kinase C in experimentally induced and regressed rat thyroid goitres. Mol Cell Endocrinol 48: 105-110
14. Öner J, Özercan I, Kükner A (2001) AgNOR quantity in thyroid follicular cells during experimental hypothyroidism (in Turkish). Firat Tip Dergisi 6: 385-388
15. Patel VA, Hill DJ, Sheppard MC, Wang F, Logan A, Eggo MC (2000) Apoptosis during goitre involution: The role of Bcl-2. J Endocrinol 164: 323-330
16. Riesco JM, Juanes JA, Carretero J, Blanco EJ, Riesco-Lopez JM, Vazquez G, Vazquez R (1998) Cell proliferation and apoptosis of thyroid follicular cells are involved in the involution of experimental non-tumoral hyperplastic goiter. Anat Embryol 198: 439-450
17. Sachs LM, Abdallah B, Hassan A, Levi G, De Luze A, Reed JC, Demeneix BA (1997) Apoptosis in Xenopus tadpole tail muscles involves Bax-dependent pathways. FASEB J 11: 801-808
18. Tamura M, Kimura H, Koji T, Tominaga T, Ashizawa K, Kiriyama T, Yokoyama N, Yoshimura T, Eguchi K, Nakane PK, Nagataki S (1998) Role of apoptosis of thyrocytes in a rat model of goiter. A possible involvement of fas system. Endocrinology 139: 3646-3653
19. Wynford-Thomas D, Stringer BMJ, Willams ED (1982) Dissociation of growth and function in the rat thyroid during prolonged goitrogen administration. Acta Endocrinol 101: 210-216
20. Zhang Y, Ji Q, Zhang W (2001) Expression of apoptosis-related proteins in Hashimoto's thyroiditis and its pathological significance. Zhonghua Yi Xue Za Zhi (Abstract) 81: 432-434