Does oral zinc supplementation promote healing of chronic wounds?

Journal of Wound, Ostomy and Continence Nursing

Volumn 30, Issue 6, 2003, Pages 295-299

  Gray, Mikel ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; COPPER; CYTOKINE; EPIDERMAL GROWTH FACTOR; IRON; PLACEBO; PROSTAGLANDIN E2; SILVER DERIVATIVE; ZINC; ZINC SULFATE;

ABSORPTION; ANEMIA; B LYMPHOCYTE; BIOAVAILABILITY; BLOOD VESSEL; CELL FUNCTION; CELL VIABILITY; CHRONIC DISEASE; CLINICAL TRIAL; COPPER DEFICIENCY; DATA BASE; DECUBITUS; DIARRHEA; DISEASE ASSOCIATION; DISEASE EXACERBATION; DNA SYNTHESIS; DRUG BIOAVAILABILITY; DRUG EFFECT; DRUG MEGADOSE; DRUG SAFETY; GASTROINTESTINAL SYMPTOM; GRANULOCYTE; HUMAN; IMMUNITY; INFLAMMATION; LEG ULCER; MEDLINE; MONOCYTE; NATURAL KILLER CELL; NAUSEA; NEUTROPHIL; NONHUMAN; PHAGOCYTE; PHAGOCYTOSIS; REVIEW; SIDE EFFECT; T LYMPHOCYTE; TISSUE REGENERATION; TISSUE REPAIR; ULCER; VITAMIN SUPPLEMENTATION; VOMITING; WOUND HEALING; ZINC BLOOD LEVEL; ZINC DEFICIENCY;

ADMINISTRATION, ORAL; CHRONIC DISEASE; DIETARY SUPPLEMENTS; EVIDENCE-BASED MEDICINE; HUMANS; LEG ULCER; NUTRITION POLICY; PRESSURE ULCER; SAFETY; TREATMENT OUTCOME; WOUND HEALING; ZINC; ZINC SULFATE;

EID: 0242629017     PISSN: 10715754     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1071-5754(03)00515-1     Document Type: Article

References (36)

1. NIH Clinical Center. Facts about dietary supplements: zinc. Downloaded from URL: http://www.cc.nih.gov/ccc/supplements/zinc.pdf, July 30, 2003.
2. Lansdown A.B. Zinc in the healing wound. Lancet. 347:(9003):1996;706-707.
3. Micheletti A., Rossi R., Rufini S. Zinc status in athletes: relation to diet and exercise. Sports Med. 31:(8):2001;577-582.
4. Kohn S., Kohn D., Schiller D. Effect of zinc supplementation on epidermal Langerhans' cells of elderly patients with decubital ulcers. J Dermatol. 27:(4):2000;258-263.
5. Wilkinson E.A.J., Hawke C.I. Does oral zinc aid in the healing of chronic leg ulcers? Arch Dermatol. 134:(12):1998;1556-1560.
6. Doherty C.P., Weaver L.T., Prentice A.M. Micronutrient supplementation and infection: a double-edged sword. J Pediatr Gastroenterol Nutr. 34:2002;346-352.
7. Henzel J.H., DeWeese M.S., Lichti E.L. Zinc concentrations within healing wounds. Significance of postoperative zincuria on availability and requirements during tissue repair. Arch Surg. 100:(4):1970;349-357.
8. Gonul B., Soylemezoglu T., Yanicoglu L., Guvendik G. Effects of epidermal growth factor on zinc plasma and prostaglandin levels of mice with pressure sores. Prostaglandins. 45:(2):1993;153-157.
9. Rink L., Gabriel P. Zinc and the immune system. Proc Nutr Soc. 59:(4):2000;541-552.
10. IBS, KH, Rink L. Zinc-altered immune function. J Nutr. 133:(5 supplement 1):2003;1452S-1456S.
11. Erdogan M., Ilhan Y.S., Akkus M.A., Caboglu S.A., Ozercan I., Ilhan N., Yaman M. Effects of L-thyroxine and zinc therapy on wound healing in hypothyroid rats. Acta Chir Belg. 99:(2):1999;72-77.
12. Senapati A., Thompson R.P. Zinc deficiency and the prolonged accumulation of zinc in wounds. British J Surg. 72:(7):1985;583-584.
13. Franzen L.E., Ghassemifar M.R. Connective tissue repair in zinc deficiency. An ultrastructural morphometric study in perforated mesentery in rats. Eur J Surg. 158:(6-7):1992;333-337.
14. Cruse J.M., Lewis R.E. Dilioglou S, Roe DL, Wallace WF, Chen RS. Review of immune function, healing of pressure ulcers and nutritional status in patients with spinal cord injury. J Spin Cord Med. 23:(2):2000;129-135.
15. Rudman D., Abbassi A.A., Isaacson K., Karpiuk E. Observations on the nutrient intakes on eating-dependent nursing home resident: underutilization of micronutrient supplements. J Am Coll Nutr. 14:(6):1995;604-613.
16. Williams C.M., Lines C.M., McKay E.C. Iron and zinc status in multiple sclerosis patients with pressure sores. European J Clin Nutr. 42:(4):1988;321-328.
17. Balaji P., Mosley J.G. Evaluation of vascular and metabolic deficiency in patients with large leg ulcers. Ann R Coll Surg Engl. 77:(4):1975;270-272.
18. McBean L.D., Smith J.C., Berne B.H., Halsted J.A. Serum zinc and alpha-2 macroglobulin concentration in myocardial infarction, decubitus ulcer, multiple myeloma, prostatic carcinoma, Down's syndrome and nephrotic syndrome. Clin Chim Acta. 50:1974;43-51.
19. Hotz C., Lowe N.M., Araya M., Brown K.H. Assessment of the trace element status of individuals and populations: the example of zinc and copper. J Nutr. 133:(5 supplement 1):2003;1563S-1568S.
20. Jacobs D.S., Demott W.R., Finley P.R., Horvat R.T., Kasten B.L., Lowell L.T. Laboratory Test Handbook. 3rd edition: 1994;Lexi-Comp, Hudson, OH.
21. Watkin D.M., Waldron W.D. A double-blind study of supplemental zinc in the management of pressure ulcers. Fed Proc. 40:(3 II):1981;3559.
22. Brewer R.D. Jr., Leal J.F., Mihaldzic N. Preliminary observations on the effect of oral zinc sulfate on the healing of decubitus ulcers. Proc Ann Clin Spin Cord Inj Conf. 15:1966;93-96.
23. Cohen C. Zinc sulphate and bedsores. Br Med J. 2:(604):1968;561.
24. Abbott D.F., Exton-Smith A.N., Millard P.H., Temperley J.M. Zinc sulphate and bedsores. Br Med J. 2:(607):1968;763.
25. Greaves M.W., Skillen A.W. Effects of long-continued ingestion of zinc sulfate in patients with venous leg ulceration. Lancet. 2:(7679):1970;889-891.
26. Clayton R.J. Double-blind trial of oral zinc sulphate in patients with leg ulcers. Br J Clin Prac. 26:(8):1972;368-370.
27. Phillips A., Davidson M., Greaves M.W. Venous leg ulceration: evaluation of zinc treatment, serum zinc and rate of healing. Clin Exp Dermat. 2:(24):1977;395-399.
28. Hallbook T., Lanner E. Serum-zinc and healing of venous ulcers. Lancet. 2:(7781):1972;780-782.
29. Haeger K., Lanner E. Oral zinc sulphate and ischemic leg ulcers. VASA. 3:(1):1974;77-81.
30. Haeger K., Lanner E., Magnusson P.O. Oral zinc sulphate in the treatment of venous leg ulcers. VASA. 1:(1):1972;62-69.
31. Greaves M.W., Ive F.A. Double blind trial of zinc sulphate in the treatment of chronic venous leg ulceration. Br J Dermatol. 87:(6):1972;632-634.
32. Wilkinson A.J., Hawke C.I. Does oral zinc aid in the healing of leg ulcers? Arch Dermatol. 134:1998;1556-1560.
33. Scholl D., Langkamp-Henken B. Nutrition recommendations for wound healing. J Intravenous Nurs. 24:(2):2001;124-132.
34. Lewis M.R., Kokan L. Zinc gluconate: acute ingestion. J Toxicol Clin Toxicol. 36:(1-2):1998;99-101.
35. Chandra R.K. Excessive intake of zinc impairs immune responses. JAMA. 252:1984;1443-1446.
36. Summerfield A.L., Steinberg F.U., Gonzalex J.G. Morphologic findings in bone marrow precursor cells in zinc-induced copper deficiency anemia. Am J Clin Path. 97:(5):1992;665-668.