Palladium-Catalyzed Cross-Coupling of Acetates of Baylis-Hillman Adducts and Potassium Organotrifluoroborates

Organic Letters

Volumn 5, Issue 21, 2003, Pages 3803-3805

  Kabalka, George W ^a   Venkataiah, Bollu ^a   Dong, Gang ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID DERIVATIVE; BORIC ACID; BORON; METHANOL; PALLADIUM; POTASSIUM; SODIUM CHLORIDE; SOLVENT;

ARTICLE; BAYLIS HILLMAN ADDUCT; CATALYSIS; CATALYST; CHEMICAL REACTION; STEREOCHEMISTRY;

EID: 0242628820     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol0351798     Document Type: Article

References (37)

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37. 2 is added to a solution of potassium organotrifluoroborate salt 2 (1 mmol) in methanol (5 mL) at 0°C under a nitrogen atmosphere. The reaction mixture is allowed to stir at room temperaure until completion (TLC monitoring). The mixture is then diluted with diethyl ether (10 mL) and filtered to remove solids. The solvent is removed under reduced pressure and the product purified by chromatography (silica gel) to afford analytically pure product.