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Volumn 14, Issue 22, 2003, Pages 3435-3446

A convergent asymmetric synthesis of a growth hormone secretagogue

Author keywords

[No Author keywords available]

Indexed keywords

BENZOLACTAM; GROWTH HORMONE SECRETAGOGUE; LACTAM DERIVATIVE; UNCLASSIFIED DRUG; UREA DERIVATIVE;

EID: 0242626791     PISSN: 09574166     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetasy.2003.09.022     Document Type: Article
Times cited : (15)

References (21)
  • 2
    • 85030951040 scopus 로고    scopus 로고
    • Schoen, W. R.; Wyvratt, M. J.; Smith, R. G. Annual Reports in Medicinal Chemistry Bristol, J. A., Ed.; Academic Press: California, 1993; Vol. 28, Chapter 19.
  • 7
    • 85030947485 scopus 로고    scopus 로고
    • Presented at the IBS conference, Peptidomimetics and Small Molecule Design: Accelerating Drug Discovery and Development, Philadelphia, PA, March 10-12, 1997. The edited and updated transcript from this conference was published by IBC in November, 1997 (IBC Library Series publication #984, pp. 163-170).
    • Presented at the IBS conference, Peptidomimetics and Small Molecule Design: Accelerating Drug Discovery and Development, Philadelphia, PA, March 10-12, 1997. The edited and updated transcript from this conference was published by IBC in November, 1997 (IBC Library Series publication #984, pp. 163-170).
  • 8
    • 85030949891 scopus 로고    scopus 로고
    • Other solvents have been demonstrated on the steroidal substrates only.
    • Other solvents have been demonstrated on the steroidal substrates only.
  • 9
    • 85030948811 scopus 로고    scopus 로고
    • 2 was unsuccessful
    • 2 was unsuccessful.
  • 11
    • 85030951788 scopus 로고    scopus 로고
    • 13C 1D NMR as well as a 2D inverse long range correlation experiments were used to characterize the adduct.
    • 13C 1D NMR as well as a 2D inverse long range correlation experiments were used to characterize the adduct.
  • 12
    • 0000358994 scopus 로고    scopus 로고
    • 2 may occur simply by an extension of an intramolecular Hofmann-Loffler-Freytag reaction.
  • 16
    • 0000340791 scopus 로고
    • For the preparation of (2-formylphenyl)boronic acid, see:
    • For the preparation of (2-formylphenyl)boronic acid, see: Wytko J.A., Graf E., Weiss J. J. Org. Chem. 57:1992;1015-1018.
    • (1992) J. Org. Chem. , vol.57 , pp. 1015-1018
    • Wytko, J.A.1    Graf, E.2    Weiss, J.3
  • 18
    • 85030940542 scopus 로고    scopus 로고
    • The structures of dibenzyl amine and tribenzyl amine are: Apparently the reaction of the primary imine with the mono or dibenzyl amine occurred faster than the reduction of the primary imine.
    • The structures of dibenzyl amine and tribenzyl amine are: Apparently the reaction of the primary imine with the mono or dibenzyl amine occurred faster than the reduction of the primary imine.
  • 21
    • 85030951702 scopus 로고    scopus 로고
    • For bulk drug products, no more than 10 ppm of any heavy metal may be present in the final product.
    • For bulk drug products, no more than 10 ppm of any heavy metal may be present in the final product.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.