Predictive Factors of Response of Perianal Crohn's Disease to Azathioprine or 6-Mercaptopurine

Diseases of the Colon and Rectum

Volumn 46, Issue 11, 2003, Pages 1469-1475

  Lecomte, Thierry ^a   Contou, Jean François ^a   Beaugerie, Laurent ^a   Carbonnel, Franck ^a   Cattan, Stéphane ^a   Gendre, Jean Pierre ^a   Cosnes, Jacques ^a  

^a HÔPITAL SAINT ANTOINE   (France)

Author keywords

6 Mercaptopurine; Anus diseases; Azathioprine; Crohn's disease; Rectal fistula; Rectovaginal fistula; Treatment outcome

Indexed keywords

AZATHIOPRINE; CIPROFLOXACIN; CLOFAZIMINE; MERCAPTOPURINE; MESALAZINE; METRONIDAZOLE; SALAZOSULFAPYRIDINE;

ADULT; AGE; ANUS DISEASE; ARTICLE; CROHN DISEASE; DISEASE DURATION; FEMALE; FOLLOW UP; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; MAJOR CLINICAL STUDY; MALE; RECTOVAGINAL FISTULA; RECTUM FISTULA; REMISSION; STATISTICAL ANALYSIS;

6-MERCAPTOPURINE; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANUS DISEASES; AZATHIOPRINE; CONFIDENCE INTERVALS; CROHN DISEASE; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; MIDDLE AGED; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RECTAL FISTULA; RECURRENCE; RISK FACTORS; TREATMENT OUTCOME;

EID: 0242594543     PISSN: 00123706     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10350-004-6795-7     Document Type: Article

References (39)

1. Rankin GB, Watts HD, Melnyk CS, Kelley ML Jr. National Cooperative Crohn's Disease Study: extraintestinal manifestations and perianal complications. Gastroenterology 1979;77:914-20.
2. Bernard D, Morgan S, Tasse D. Selective surgical management of Crohn's disease of the anus. Can J Surg 1986;29:318-21.
3. Keighley MR, Allan RN. Current status and influence of operation on perianal Crohn's disease. Int J Colorectal Dis 1986;1:104-7.
4. Schwartz DA, Pemberton JH, Sandborn WJ. Diagnosis and treatment of perianal fistulas in Crohn's disease. Ann Intern Med 2001;135:906-18.
5. Williams JG, MacLeod CA, Rothenberger DA, Goldberg SM. Seton treatment of high anal fistulae. Br J Surg 1991;78:1159-61.
6. Williamson PR, Hellinger MD, Larach SW, Ferrara A. Twenty-year review of the surgical management of perianal Crohn's disease. Dis Colon Rectum 1995;38:389-92.
7. Michelassi F, Melis M, Rubin M, Hurst RD. Surgical treatment of anorectal complications in Crohn's disease. Surgery 2000;128:597-603.
8. Faucheron JL, Saint-Marc O, Guibert L, Parc R. Long-term seton drainage for high anal fistulas in Crohn's disease: a sphincter-saving operation? Dis Colon Rectum 1996;39:208-11.
9. Present DH. 6-Mercaptopurine and other immunosuppressive agents in the treatment of Crohn's disease and ulcerative colitis. Gastroenterol Clin North Am 1989;18:57-71.
10. Nielsen OH, Vainer B, Rask-Madsen J. Review article: the treatment of inflammatory bowel disease with 6-mercaptopurine or azathioprine. Aliment Pharmacol Ther 2001;15:1699-708.
11. Korelitz BI, Present DH. Favorable effect of 6-mercaptopurine on fistulae of Crohn's disease. Dig Dis Sci 1985;30:58-64.
12. Korelitz BI. Steroids may prevent leukopenia, interfering with response to IV azathioprine in treatment of Crohn's disease. Gastroenterology 2000;118:1281-2.
13. O'Brien JJ, Bayless TM, Bayless JA. Use of azathioprine or 6-mercaptopurine in the treatment of Crohn's disease. Gastroenterology 1991;101:39-46.
14. Nyman M, Hansson I, Eriksson S. Long-term immunosuppressive treatment in Crohn's disease. Scand J Gastroenterol 1985;20:1197-203.
15. Korelitz BI, Adler DJ, Mendelsohn RA, Sacknoff AL. Long-term experience with 6-mercaptopurine in the treatment of Crohn's disease. Am J Gastroenterol 1993;88:1198-205.
16. Present DH, Korelitz BI, Wisch N, Glass JL, Sachar DB, Pasternack BS. Treatment of Crohn's disease with 6-mercaptopurine. A long-term, randomized, double-blind study. N Engl J Med 1980;302:981-7.
17. Jeshion WC, Larsen KL, Jawad AF, et al. Azathioprine and 6-mercaptopurine for the treatment of perianal Crohn's disease in children. J Clin Gastroenterol 2000;30:294-8.
18. McKee RF, Keenan RA. Perianal Crohn's disease: is it all bad news? Dis Colon Rectum 1996;39:136-42.
19. Present DH, Rutgeerts P, Targan S, et al. Infliximab for the treatment of fistulas in patients with Crohn's disease. N Engl J Med 1999;340:1398-405.
20. Ouraghi A, Nieuviarts S, Mougenel JL, et al. Infliximab therapy for Crohn's disease anoperineal lesions. Gastroenterol Clin Biol 2001;25:949-56.
21. Arseneau KO, Cohn SM, Cominelli F, Connors AF Jr. Cost-utility of initial medical management for Crohn's disease perianal fistulae. Gastroenterology 2001;120:1640-56.
22. Lennard-Jones JE. Classification of IBD. Scand J Gastroenterol 1989;170:2-4.
23. Hughes LE. Surgical pathology and management of anorectal Crohn's disease. J R Soc Med 1978;71:644-51.
24. Harvey RF, Bradshaw JM. A simple index of Crohn's-disease activity. Lancet 1980;1:514.
25. Pearson DC, May GR, Fick GH, Sutherland LR. Azathioprine and 6-mercaptopurine in Crohn's disease. A metaanalysis. Ann Intern Med 1995;123:132-42.
26. Hughes LE. Clinical classification of perianal Crohn's disease. Dis Colon Rectum 1992;35:928-32.
27. Cosnes J, Carbonnel F, Beaugerie L, Le Quintrec Y, Gendre JP. Effects of cigarette smoking on the long-term course of Crohn's disease. Gastroenterology 1996;110:424-31.
28. Contou JF, Maurel J, Gallot D, Malafosse M. The surgeon faced with ano-perineal lesions of Crohn's disease [in French]. Ann Gastroenterol Hepatol 1990;26:263-70.
29. Scott NA, Nair A, Hughes LE. Anovaginal and rectovaginal fistula in patients with Crohn's disease. Br J Surg 1992;79:1379-80.
30. Gasche C, Scholmerich J, Brynskov J, et al. A simple classification of Crohn's disease: report of the Working Party for the World Congresses of Gastroenterology, Vienna 1998. Inflamm Bowel Dis 2000;6:8-15.
31. Siproudhis L, Mortaji A, Mary JY, Juguet F, Bretagne JF, Gosselin M. Anal lesions: any significant prognosis in Crohn's disease? Eur J Gastroenterol Hepatol 1997;9:239-43.
32. Frizelle FA, Santoro GA, Pemberton JH. The management of perianal Crohn's disease. Int J Colorectal Dis 1996;11:227-37.
33. Markowitz J, Rosa J, Grancher K, Aiges H, Daum F. Long-term 6-mercaptopurine treatment in adolescents with Crohn's disease. Gastroenterology 1990;99:1347-51.
34. Makowiec F, Jehle EC, Becker H-D, Starlinger M. Perianal abscess in Crohn's disease. Dis Colon Rectum 1997;40:443-50.
35. Wolff BG, Culp CE, Beart RW Jr, Ilstrup DM, Ready RL. Anorectal Crohn's disease: a long-term perspective. Dis Colon Rectum 1985;28:709-11.
36. Scott HJ, Northover JM. Evaluation of surgery for perianal Crohn's fistulas. Dis Colon Rectum 1996;39:1039-43.
37. Buchmann P, Keighley MR, Allan RN, Thompson H, Alexander-Williams J. Natural history of perianal Crohn's disease. Ten-year follow-up: a plea for conservatism. Am J Surg 1980;140:642-4.
38. Bouhnik Y, Lemann M, Mary JY, et al. Long-term follow-up of patients with Crohn's disease treated with azathioprine or 6-mercaptopurine. Lancet 1996;347:215-9.
39. Kim PS, Zlatanic J, Korelitz BI, Gleim GW. Optimum duration of treatment with 6-mercaptopurine for Crohn's disease. Am J Gastroenterol 1999;94:3254-7.